Radiology:或许这才是靠谱体脂率测量的方法!

2020-04-10 shaosai MedSci原创

代谢综合征是与肥胖和异位脂肪分布是有相关性的。

背景

代谢综合征是与肥胖和异位脂肪分布是有相关性的。

目的

本研究旨在评价是否有一种图像分析方法通过图像配比来进行全身基于体素的分析,并能够对代谢综合征与身体成分间的相关性提供额外信息。

方法

对有关肥胖、精力和代谢相关研究人群进行全身定量水脂MRI。利用双能量X线吸收测量法(DXA)对脂肪量进行测量。利用自动匹配分割技术对全身体素进行基于体素的组织体积和脂肪成分进行测量。参照改良版NCEP标准对代谢综合征进行诊断。

结果

本研究共纳入了167例女性患者和159例男性患者进行基于体素分析。代谢综合征与脂肪分布传统指标具有相关性,例如DXA总脂肪量、内脏和皮下脂肪组织、肝脏脂肪含量和胰腺脂肪含量。基于体素分析显示代谢综合征与肝脏、心脏和肾周脂肪脂肪体积具有相关性;与男性和女性臀部皮下脂肪的含量、男性腿部肌肉脂肪浸润(尤其是臀大肌)具有相关性;而仅与女性心包和主动脉周围的血管脂肪具有相关性。皮下脂肪体积与代谢综合征间的相关性是有性别差异的。在女性中,代谢综合征的诊断与不同位置脂肪体积的相关性具有差异,如上肢与下肢、背侧和腹侧。

结论

本研究除了详细、直观地展现了代谢综合征与脂肪成分的相关性。全身基于体素分析要较传统图像分析提供更多的信息。

原始出处:

Lind L, Strand R, Michaëlsson K.et al. Voxel-wise Study of Cohort Associations in Whole-Body MRI: Application in Metabolic Syndrome and Its Components. DOI:10.1148/radiol.2019191035

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