J Am Podiatr Med Assoc:富血小板血浆治疗糖尿病足溃疡的疗效如何?

2021-08-19 MedSci原创 MedSci原创

糖尿病足溃疡(DFU)可以通过控制感染、血糖正常状态和溃疡清创来得到很好的控制,然后进行适当的包扎和足部减压。研究表明,大约90%的DFU经过适当的减压休息后在近6周内痊愈。富血小板血浆(PRP)可作

糖尿病足溃疡(DFU)可以通过控制感染、血糖正常状态和溃疡清创来得到很好的控制,然后进行适当的包扎和足部减压。研究表明,大约90%的DFU经过适当的减压休息后在近6周内痊愈。富血小板血浆(PRP)可作为生长因子的激动剂,具有有丝分裂和趋化的特性,有助于DFU的愈合。

发表于J Am Podiatr Med Assoc的一项随机研究评估了局部应用PRP对治疗DFU的愈合率和溃疡面积减少的疗效。

研究共纳入60名未感染的DFU患者(足底表面积≤20cm2;Meggitt-Wagner 1级和2级),随机分配接受正常生理盐水敷料(对照组[CG])或PRP敷料(研究组[SG]),同时进行6周的全接触管型石膏,或直到溃疡完全愈合,以较早者为准。每周对愈合率和溃疡面积的变化进行评估。

结果显示,基线时平均±SD溃疡面积为4.96±2.89cm2(CG)和5.22±3.82cm2(SG)(P=0.77),6周时减少到1.15±1.35cm2(CG)和0.96±1.53cm2(SG)(P=0.432)。6周时愈合面积的平均±SD百分比减少为81.72%±17.2%(CG)和85.98%±13.42%(SG)(P=0.29)。6周时的平均±SD愈合率为0.64±0.36cm2(CG)和0.71±0.46cm2(SG)(P = .734)。

综上所述,该研究结果表明,PRP敷料在治疗DFU时并不比正常的生理盐水敷料更有效,同时配合全接触管型石膏。

原始出处:

Ajay Gupta, et al., Efficacy of Intralesional Platelet-Rich Plasma in Diabetic Foot Ulcer. J Am Podiatr Med Assoc. 2021 May 1;111(3):Article_7. doi: 10.7547/19-149.

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  8. [GetPortalCommentsPageByObjectIdResponse(id=1648562, encodeId=c66c16485622e, content=<a href='/topic/show?id=531793000f9' target=_blank style='color:#2F92EE;'>#足溃疡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93000, encryptionId=531793000f9, topicName=足溃疡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=943123606403, createdName=meichuangyi, createdTime=Sat Oct 30 21:21:42 CST 2021, time=2021-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1667238, encodeId=0780166e23890, content=<a href='/topic/show?id=ea04891988c' target=_blank style='color:#2F92EE;'>#血浆治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89198, encryptionId=ea04891988c, topicName=血浆治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150026134820, createdName=jianjun75, createdTime=Mon Jun 06 23:21:42 CST 2022, time=2022-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1811956, encodeId=d6b918119563c, content=<a href='/topic/show?id=5ab78905623' target=_blank style='color:#2F92EE;'>#血小板血浆#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89056, encryptionId=5ab78905623, topicName=血小板血浆)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8ebc122, createdName=yankaienglish, createdTime=Sat Jan 08 09:21:42 CST 2022, time=2022-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1639847, encodeId=a073163984eeb, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Tue Dec 28 01:21:42 CST 2021, time=2021-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1340366, encodeId=789a134036697, content=<a href='/topic/show?id=26bd465e2e3' target=_blank style='color:#2F92EE;'>#富血小板血浆#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46572, encryptionId=26bd465e2e3, topicName=富血小板血浆)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3c932500160, createdName=ms7421025882867189, createdTime=Sat Aug 21 13:21:42 CST 2021, time=2021-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512550, encodeId=da6f15125503f, content=<a href='/topic/show?id=881ce679132' target=_blank style='color:#2F92EE;'>#糖尿病足溃疡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76791, encryptionId=881ce679132, topicName=糖尿病足溃疡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a50210475224, createdName=ms3875500703114551, createdTime=Sat Aug 21 13:21:42 CST 2021, time=2021-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1611231, encodeId=8c0d161123167, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sat Aug 21 13:21:42 CST 2021, time=2021-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1033092, encodeId=95c9103309225, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Fri Aug 20 01:21:42 CST 2021, time=2021-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043747, encodeId=274d1043e47b6, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Fri Aug 20 01:21:42 CST 2021, time=2021-08-20, status=1, ipAttribution=)]
    2021-08-20 内科新手

    谢谢梅斯提供这么好的信息,学到很多

    0

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    2021-08-20 misszhang

    谢谢MedSci提供最新的资讯

    0

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