Ann Rheum Dis:自身免疫性疾病患者感染COVID-19的临床特征

2020-06-19 xiangting MedSci原创

有慢性合并症的老年男性更容易出现重症COVID-19。全身性AIDs患者感染COVID-19的比例较低。

普通人群感染COVID-19的数据越来越多。这项研究旨在进一步评估全身性自身免疫性疾病患者(AIDs)感染COVID-19的临床特征。

研究纳入2020年1月29日至3月8日在武汉同济医院住院所有被确诊为COVID-19的全身性AIDs患者。回顾性收集和分析了1255例住院患者的流行病学资料以及全身性AIDs患者的其他临床特征。随访至2020年4月16日。

1255例COVID-19患者中,中位年龄为64.0岁,男性占53.1%。一半以上的患者(63.0%)有慢性合并症。重症监护病房(ICU)里老年人、男性和有合并症的患者比例明显高于普通病房(p<0.001)。从2804例住院患者中进一步筛选和分析了17例(0.61%)全身性AIDs患者。中位年龄为64.0岁,女性占82.4%。所有患者均生活在武汉,并发现了2个家族聚集病例。1例患者(5.9%)被送入ICU,1例死亡。16例患者中有10例(62.5%)在住院期间更改或停止了抗AIDs治疗,其中5例在隔离后感到疾病恶化。

有慢性合并症的老年男性更容易出现重症COVID-19。全身性AIDs患者感染COVID-19的比例较低,这需要更多高质量的人体临床试验和深入的机制研究。值得注意的是,住院期间停用抗AIDs治疗可能导致疾病发作。

原始出处:

Yao Huang. Clinical characteristics of 17 patients with COVID-19 and systemic autoimmune diseases: a retrospective study. Ann Rheum Dis. 16 June 2020.

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    2020-06-19 lovetcm

    住院期间停用抗AIDs治疗可能导致疾病发作。

    0

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