Cancer:接受根治性前列腺切除术后的前列腺癌死亡率的种族差异

2020-09-10 AlexYang MedSci原创

尽管前列腺癌生存率的种族差异已被详细的记录,但导致差异的各种因素的相对重要性人们仍不清楚。也少有研究考察白人与西班牙裔、白人与亚裔美国人和太平洋岛民(AAPIs)之间的差异。

尽管前列腺癌生存率的种族差异已被详细的记录,但导致差异的各种因素的相对重要性人们仍不清楚。也少有研究考察白人与西班牙裔、白人与亚裔美国人和太平洋岛民(AAPIs)之间的差异。

在近期发表在Cancer期刊的一项研究中,来自美国范德堡大学的科学家利用2004年至2014年全国癌症数据库中526690例前列腺癌根治性切除术患者的数据,系统地评估了临床特征和与获得护理相关的因素对种族生存率的影响。纳入分析的为白人患者432,640例(82.1%),黑人患者63,602例(12.1%),AAPI患者8990例(1.7%),以及西班牙裔患者21,458例(4.1%)。他们使用多变量Cox比例风险模型来估计风险比和95%置信区间,以衡量种族生存差异,并用逆概率加权来调整预后因素的不平衡。

结果显示,当仅调整年龄和诊断年份因素时,黑人的死亡率要比白人高51%,AAPIs的死亡率要低22%,西班牙裔的死亡率要比白人低6%。总的来说,在对所有临床因素和非临床因素进行调整后,黑人和白人的生存差异缩小到20%,而AAPI和白人的差异增加到35%。在可控因素中,教育、家庭收入中位数和保险状况对种族差异的影响最大。

不同种族前列腺癌患者的生存概率

综上所述,在对一些临床因素和与获得护理相关的因素进行调整后,接受根治性前列腺切除术的黑人男性与白人间的总体生存差异显著减小,但并未消除,而AAP与白人的生存差异显著增大。

原始出处:

Wanqing Wen, Amy N. Luckenbaugh, Christina E. Bayley et al. Racial Disparities in Mortality for Patients With Prostate Cancer After Radical Prostatectomy. Cancer. August 2020

 

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    2020-09-13 wxl882001

    了解

    0

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  5. 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objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Thu Sep 10 23:53:38 CST 2020, time=2020-09-10, status=1, ipAttribution=)]
    2020-09-12 docwu2019
  6. 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    2020-09-11 Jessica

    即使调整了一些临床因素和与获得护理相关的因素,接受根治性前列腺切除术的黑人男性与白人间的总体生存差异还是存在的。

    0

  7. 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    2020-09-11 医鸣惊人

    认真学习了

    0

  8. 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objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Thu Sep 10 23:53:38 CST 2020, time=2020-09-10, status=1, ipAttribution=)]
    2020-09-11 医鸣惊人

    学习

    0

  9. 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objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Thu Sep 10 23:53:38 CST 2020, time=2020-09-10, status=1, ipAttribution=)]
    2020-09-11 1205a032m39(暂无昵称)

    学习

    0

  10. 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objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Thu Sep 10 23:53:38 CST 2020, time=2020-09-10, status=1, ipAttribution=)]
    2020-09-10 misszhang

    前列腺癌相关研究,学习了,谢谢梅斯

    0

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Eur Urol:科学家在具有前列腺癌家族史和侵袭性前列腺癌患者中鉴定了10个与前列腺癌风险相关的新基因

众所周知,家族史是前列腺癌的一个危险因素,常见和罕见的基因变异都与该疾病有关。最近一项发表在Eur Urol期刊的研究中,来自美国梅奥诊所、澳大利亚墨尔本大学、德国乌尔姆大学等多国机构的研究人员利用家

Cell Death Dis:PLCɛ对前列腺癌中AR信号的功能维持至关重要

前列腺癌(CaP)作为男性最常见的恶性肿瘤之一,在美国的估计新发病例中排名第一,癌症相关死亡中排名第三。雄激素受体(AR)信号通路在CaP的发生发展中起着至关重要的作用。AR信号的过度激活会促进细胞增

Nat Commun:DOT1L调控前列腺癌中AR和MYC的稳定性

组蛋白甲基转移酶目前已成为肿瘤学中的一个重要治疗靶标,但其在多种恶性肿瘤发病机制中的作用还知之甚少。DOT1L是一种组蛋白甲基转移酶,可甲基化组蛋白H32的第79位赖氨酸。H3K79甲基化主要与转录激

Molecular Cell:DNA损伤促进TMPRSS2-ERG癌蛋白降解并抑制前列腺癌进展

前列腺癌(PCa)作为男性中最常被诊断出的癌症,其是西方国家男性的癌症相关死亡中的第二大主因。目前局部PCa的治疗方法包括手术和放疗,而雄激素剥夺疗法(ADT)是晚期PCa的主要治疗手段。

Prostate Cancer P D:两种消融技术治疗放射复发前列腺癌的长期结果

前列腺癌放疗后复发的男性,进一步治疗仍旧是一个挑战。常规的雄激素剥夺疗法(ADT)挽救方案有不良影响。另外,只有选择的部分男性可以进行挽救性治疗。最近,有研究人员阐释了两种全腺消融技术-冷冻疗法(sC