AP&T: 糖尿病会导致肝硬化患者肝性脑病的发生

2020-07-20 MedSci原创 MedSci原创

糖尿病可能导致血清氨水平升高和全身性炎症,从而促进肝性脑病(HE)。为了研究糖尿病与血糖控制与隐性HE的存在的关系,本项研究进行了相关实验。

背景

糖尿病可能导致血清氨水平升高和全身性炎症,从而促进肝性脑病(HE)。为了研究糖尿病与血糖控制与隐性HE的存在的关系,本项研究进行了相关实验。

 

方法

这项前瞻性队列研究共纳入了240名肝硬化患者,中位随访时间为17个月。隐匿性HE通过门系统性肝性脑病评分的病理结果诊断。使用logistic回归或Cox回归模型分析了隐性HE的存在或明显HE发生的预测因素。

 

结果

在纳入研究时,有33.3%的患者发现了65例(27.1%)患有糖尿病和隐蔽性HE的患者。与没有糖尿病的患者相比,患有糖尿病的患者的肝功能得以保留。在对混杂因素进行调整后的回归分析中,糖尿病与研究纳入时隐性HE的存在以及随访期间明显HE的发生独立相关。这些关联在单独的倾向评分加权回归模型中得到证实。在亚组分析中,血糖控制较差(HbA1c> = 6.5%)的患者有明显的隐匿性HE(OR 2.264,95%CI 1.002-5.118)和明显的HE症状(HR 4.116,95%CI 1.791-9.459)。

 

结论

肝硬化患者中,糖尿病可能与存在隐匿性HE和发生明显HE的风险较高有关。适当的血糖控制可能是减轻这一重要并发症的重要手段。

 

原始出处:

Christian Labenz. Et al. Association between diabetes mellitus and hepatic encephalopathy in patients with cirrhosis. Alimentary Pharmacology and Therapeutics.2020.

 

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1666459, encodeId=d336166645962, content=<a href='/topic/show?id=55c6849451c' target=_blank style='color:#2F92EE;'>#脑病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84945, encryptionId=55c6849451c, topicName=脑病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=db0126060584, createdName=showtest, createdTime=Thu Jun 03 17:43:14 CST 2021, time=2021-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043224, encodeId=bc3a104322471, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Mon Jul 20 11:43:14 CST 2020, time=2020-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046448, encodeId=c8bd104644844, content=谢谢!最新的信息读起来就是收获大, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Mon Jul 20 11:43:14 CST 2020, time=2020-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=803448, encodeId=766380344802, content=学到了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d4f25135302, createdName=14664e41m61暂无昵称, createdTime=Mon Jul 20 10:20:54 CST 2020, time=2020-07-20, status=1, ipAttribution=)]
    2021-06-03 showtest
  2. [GetPortalCommentsPageByObjectIdResponse(id=1666459, encodeId=d336166645962, content=<a href='/topic/show?id=55c6849451c' target=_blank style='color:#2F92EE;'>#脑病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84945, encryptionId=55c6849451c, topicName=脑病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=db0126060584, createdName=showtest, createdTime=Thu Jun 03 17:43:14 CST 2021, time=2021-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043224, encodeId=bc3a104322471, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Mon Jul 20 11:43:14 CST 2020, time=2020-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046448, encodeId=c8bd104644844, content=谢谢!最新的信息读起来就是收获大, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Mon Jul 20 11:43:14 CST 2020, time=2020-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=803448, encodeId=766380344802, content=学到了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d4f25135302, createdName=14664e41m61暂无昵称, createdTime=Mon Jul 20 10:20:54 CST 2020, time=2020-07-20, status=1, ipAttribution=)]
    2020-07-20 misszhang

    谢谢MedSci提供最新的资讯

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1666459, encodeId=d336166645962, content=<a href='/topic/show?id=55c6849451c' target=_blank style='color:#2F92EE;'>#脑病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84945, encryptionId=55c6849451c, topicName=脑病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=db0126060584, createdName=showtest, createdTime=Thu Jun 03 17:43:14 CST 2021, time=2021-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043224, encodeId=bc3a104322471, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Mon Jul 20 11:43:14 CST 2020, time=2020-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046448, encodeId=c8bd104644844, content=谢谢!最新的信息读起来就是收获大, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Mon Jul 20 11:43:14 CST 2020, time=2020-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=803448, encodeId=766380344802, content=学到了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d4f25135302, createdName=14664e41m61暂无昵称, createdTime=Mon Jul 20 10:20:54 CST 2020, time=2020-07-20, status=1, ipAttribution=)]
    2020-07-20 guging

    谢谢!最新的信息读起来就是收获大

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1666459, encodeId=d336166645962, content=<a href='/topic/show?id=55c6849451c' target=_blank style='color:#2F92EE;'>#脑病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84945, encryptionId=55c6849451c, topicName=脑病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=db0126060584, createdName=showtest, createdTime=Thu Jun 03 17:43:14 CST 2021, time=2021-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043224, encodeId=bc3a104322471, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Mon Jul 20 11:43:14 CST 2020, time=2020-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046448, encodeId=c8bd104644844, content=谢谢!最新的信息读起来就是收获大, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Mon Jul 20 11:43:14 CST 2020, time=2020-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=803448, encodeId=766380344802, content=学到了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d4f25135302, createdName=14664e41m61暂无昵称, createdTime=Mon Jul 20 10:20:54 CST 2020, time=2020-07-20, status=1, ipAttribution=)]
    2020-07-20 14664e41m61暂无昵称

    学到了。

    0

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