Cancer Immunol Immunother:混合多肽疫苗组合多烯紫杉醇和地塞米松治疗去势抵抗性前列腺癌研究

2020-02-19 AlexYang MedSci原创

之前人们开发了一种包含20种混合多肽(KRM-20)的新的癌症疫苗来诱导细胞毒性T淋巴细胞,从而抵抗12种不同的肿瘤相关的抗原。最近,有研究人员在II期试验中调查了是否KRM-20组合多烯紫杉醇和地塞米松能够在去势抵抗性前列腺癌(CRPC)患者中增强抗肿瘤作用。研究是一个双盲、安慰剂对照和随机II期研究,研究人员在日本10个医疗中心招募了无化疗CRPC患者。符合要求的患者以1:1的比例随机分配在K

之前人们开发了一种包含20种混合多肽(KRM-20)的新的癌症疫苗来诱导细胞毒性T淋巴细胞,从而抵抗12种不同的肿瘤相关的抗原。最近,有研究人员在II期试验中调查了是否KRM-20组合多烯紫杉醇和地塞米松能够在去势抵抗性前列腺癌(CRPC)患者中增强抗肿瘤作用。

研究是一个双盲、安慰剂对照和随机II期研究,研究人员在日本10个医疗中心招募了无化疗CRPC患者。符合要求的患者以1:1的比例随机分配在KRM-20组合多烯紫杉醇和地塞米松治疗组(n=25)或者安慰剂组合多烯紫杉醇和地塞米松治疗组(n=26)。主要终点是不同治疗组间的前列腺特异性抗原(PSA)减少差异。研究发现,2个小组的PSA减少相似(56.5% vs. 53.8%; P=0.851)。人类白细胞抗原(HLA)匹配的多肽特异性免疫球蛋白G(P=0.018)和CTL(P=0.007)响应在治疗后的KRM-20组中显著增加。KRM-20的增加并不增加毒性。另外,无进展和总生存(OS)在组间没有差异。KRM-20的增加是安全的,并且在CRPC患者中与对照组相比具有相似的PSA减少、HLA匹配的特异性多肽CTL和lgG响应增加。另外,亚群分析表明了他们的组合治疗方法对淋巴球比例≥26%或者PSA水平<11.2ng/ml的CRPC患者治疗更有效,但是进一步的临床研究来比较OS是需要的。

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    2020-07-12 yige2012
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    2020-02-21 fusion
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    2020-02-19 misszhang

    前列腺癌相关研究,学习了,谢谢梅斯

    0

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