J Aller Cl Imm-Pract:肾上腺素在社区中用于过敏性反应治疗的情况分析

2021-02-17 MedSci原创 MedSci原创

在全球范围内,在速发型过敏反应病例中及时使用肾上腺素治疗仍然不理想。至于实际建议,应考虑在学校和美食广场等储存肾上腺素,以增加社区肾上腺素的使用情况。

肾上腺素治疗过敏反应的社区使用率较低。了解院前环境下肾上腺素的使用比例,以及识别影响其使用的因素,将有助于制定政策和指南。近日,过敏性疾病领域权威杂志Journal of Allergy and Clinical Immunology-In Practice上发表了一篇研究文章,研究人员在PubMed和Embase数据库上进行了检索,检索截止至2020年4月。研究人员系统地回顾了主要集中在以下四个方面的研究:1)院前肾上腺素的使用;2)院前环境下使用肾上腺素的影响因素;3)肾上腺素使用的成本评估和成本-效果;4)改善过敏反应期间肾上腺素使用的方案和策略。

研究人员进行了两项采用logit变换的荟萃分析,旨在:1)计算院前过敏反应病例中肾上腺素使用率的汇总估计值;2)计算所有过敏反应病例中双相反应发生率的合并估计值。

入院前使用肾上腺素的儿童显著高于成人[20.98% (95%CI: 16.38%,26.46%) vs 7.17% (95%CI: 2.71%,17.63%),p=0.0027]。所有过敏反应病例的双相反应合并估计值为3.92%(95%CI:2.88%,5.32%)。该研究的主要研究结果表明,院前使用肾上腺素治疗速发型过敏反应仍不理想。肾上腺素使用的主要障碍是肾上腺素自注射剂的处方率低和学校缺乏肾上腺素储备。最后,在回顾计划和策略时,许多研究设计了有效的方法来促进充分并及时地使用肾上腺素。

该研究的主要结果表明,在全球范围内,在速发型过敏反应病例中及时使用肾上腺素治疗仍然不理想。至于实际建议,应考虑在学校和美食广场等储存肾上腺素,以增加社区肾上腺素的使用情况。研究人员建议在公共场所发放小册子(例如:商场、美食广场等)协助识别过敏反应,并及时给予肾上腺素治疗,以避免过敏反应病例中罕见的死亡病例。

原始出处:

Laura May Miles,et al.Community use of epinephrine for the treatment of anaphylaxis: a review and meta-analysis.J Aller Cl Imm-Pract.2021.https://doi.org/10.1016/j.jaip.2021.01.038

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    2021-02-20 百度冷门音乐贴吧

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    2021-02-19 膀胱癌
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