The Lancet:阿斯利康黑猩猩型腺病毒载体COVID-19疫苗在老年人中诱导了强烈的免疫应答

2020-11-19 MedSci原创 MedSci原创

人体内一般不存在针对黑猩猩型腺病毒的预存中和抗体,因此以黑猩猩型腺病毒载体研发的疫苗效果往往优于常见的人血清型腺病毒载体。

阿斯利康和牛津大学合作开发的黑猩猩型腺病毒载体COVID-19疫苗AZD1222(也称为ChAdOx1 nCoV-19)的II期研究数据今天在线发表在The Lancet《柳叶刀》杂志上,结果显示AZD1222在老年人中诱导了强烈的免疫应答,并且与年轻人相比,耐受性更好。

人体内一般不存在针对黑猩猩型腺病毒的预存中和抗体,因此以黑猩猩型腺病毒载体研发的疫苗效果往往优于常见的人血清型腺病毒载体。

About the Oxford COVID-19 vaccine | Research | University of Oxford

阿斯利康黑猩猩型腺病毒载体COVID-19疫苗作用示意图(图片来源:https://www.research.ox.ac.uk/Article/2020-07-19-the-oxford-covid-19-vaccine)

The Lancet的发表数据是来自正在进行的II/III期试验的II期部分,该研究招募了560名18岁及以上的健康成年人,受试者按年龄分为三个亚组:18至55岁的160名,56至69岁的160名,70岁以上240名。受试者随机接受不同剂量的AZD1222或对照疫苗。

各个年龄段的免疫应答相似

结果显示,在接受了两剂疫苗后的第28天,三个年龄组中的参与者体内抗SARS-CoV-2 spike蛋白的IgG水平相似,并且中和抗体滴度在3个年龄组中也相似。进一步的数据表明,加强剂量后14天,接受第二剂疫苗接种的209名患者中有208名具有中和抗体反应。在所有年龄组中,单一剂量AZD1222注射后,T细胞反应在第14天达到峰值。

牛津疫苗组织的联合首席研究员Maheshi Ramasamy说:“在我们的研究中,在老年人体内观察到大量的抗体和T细胞应答非常令人鼓舞。”

老年人耐受性更好

关于安全性,在给予两种剂量的AZD1222受试者中,初次接种疫苗后,在18至55岁组中,有88%的人报告了局部反应;在56至69岁组中,有73%的受试者报告了局部反应; 70岁以上的人群,只有61%有局部反应。此外,在18至55岁组中有86%的参与者发生了全身性反应,在56至69岁组中有77%的参与者发生了反应,在70岁及以上年龄组中只有65%的参与者发生了全身反应。

原始出处:

1. https://www.firstwordpharma.com/node/1775864?tsid=4

2. Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial. The Lancet. November 18, 2020

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    2021-05-20 howi
  4. [GetPortalCommentsPageByObjectIdResponse(id=1724162, encodeId=e0a71e24162bf, content=<a href='/topic/show?id=f9cfe09905f' target=_blank style='color:#2F92EE;'>#病毒载体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70990, encryptionId=f9cfe09905f, topicName=病毒载体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ebd533571600, createdName=ewsr12, createdTime=Sat Sep 25 12:40:46 CST 2021, time=2021-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1702881, encodeId=4bf81e0288134, content=<a href='/topic/show?id=1edc10330893' target=_blank style='color:#2F92EE;'>#黑猩猩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103308, encryptionId=1edc10330893, topicName=黑猩猩)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0b2b30431820, createdName=budeshao, createdTime=Mon Jan 25 01:40:46 CST 2021, time=2021-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1830907, encodeId=1f8f183090e64, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Thu May 20 18:40:46 CST 2021, time=2021-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1645489, encodeId=13d316454892f, content=<a href='/topic/show?id=db329364360' target=_blank style='color:#2F92EE;'>#载体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93643, encryptionId=db329364360, topicName=载体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=58cb23213384, createdName=mei539, createdTime=Wed Dec 02 19:40:46 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=903663, encodeId=e159903663e1, content=很有意义, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0455435910, createdName=ms9000001337953714, createdTime=Mon Nov 30 21:50:33 CST 2020, time=2020-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902998, encodeId=f7c4902998aa, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0085434907, createdName=ms7000000052289295, createdTime=Sat Nov 28 09:47:26 CST 2020, time=2020-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901071, encodeId=b4c89010e118, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=463f5433909, createdName=ms5000002033338938, createdTime=Sat Nov 21 23:07:21 CST 2020, time=2020-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1400251, encodeId=a9bd140025177, content=<a href='/topic/show?id=10cc2901458' target=_blank style='color:#2F92EE;'>#免疫应答#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29014, encryptionId=10cc2901458, topicName=免疫应答)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7a602256775, createdName=clmlylxy, createdTime=Sat Nov 21 11:40:46 CST 2020, time=2020-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=900853, encodeId=b5a99008534c, content=老年人耐受性更好! 好消息!, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Fri Nov 20 16:45:19 CST 2020, time=2020-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=900716, encodeId=2001900e16cd, content=老年人是亮点!, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210703/9c448fe1b3b54fd7bc9477662f4861bb/4bdadad22bfd46f2921aabb4c40265d3.jpg, createdBy=a8d81938466, createdName=weigq, createdTime=Fri Nov 20 09:11:43 CST 2020, time=2020-11-20, status=1, ipAttribution=)]
    2020-12-02 mei539
  5. [GetPortalCommentsPageByObjectIdResponse(id=1724162, encodeId=e0a71e24162bf, content=<a href='/topic/show?id=f9cfe09905f' target=_blank style='color:#2F92EE;'>#病毒载体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70990, encryptionId=f9cfe09905f, topicName=病毒载体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ebd533571600, createdName=ewsr12, createdTime=Sat Sep 25 12:40:46 CST 2021, time=2021-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1702881, encodeId=4bf81e0288134, content=<a href='/topic/show?id=1edc10330893' target=_blank style='color:#2F92EE;'>#黑猩猩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103308, encryptionId=1edc10330893, topicName=黑猩猩)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0b2b30431820, createdName=budeshao, createdTime=Mon Jan 25 01:40:46 CST 2021, time=2021-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1830907, encodeId=1f8f183090e64, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Thu May 20 18:40:46 CST 2021, time=2021-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1645489, encodeId=13d316454892f, content=<a href='/topic/show?id=db329364360' target=_blank style='color:#2F92EE;'>#载体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93643, encryptionId=db329364360, topicName=载体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=58cb23213384, createdName=mei539, createdTime=Wed Dec 02 19:40:46 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=903663, encodeId=e159903663e1, content=很有意义, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0455435910, createdName=ms9000001337953714, createdTime=Mon Nov 30 21:50:33 CST 2020, time=2020-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902998, encodeId=f7c4902998aa, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0085434907, createdName=ms7000000052289295, createdTime=Sat Nov 28 09:47:26 CST 2020, time=2020-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901071, encodeId=b4c89010e118, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=463f5433909, createdName=ms5000002033338938, createdTime=Sat Nov 21 23:07:21 CST 2020, time=2020-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1400251, encodeId=a9bd140025177, content=<a href='/topic/show?id=10cc2901458' target=_blank style='color:#2F92EE;'>#免疫应答#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29014, encryptionId=10cc2901458, topicName=免疫应答)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7a602256775, createdName=clmlylxy, createdTime=Sat Nov 21 11:40:46 CST 2020, time=2020-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=900853, encodeId=b5a99008534c, content=老年人耐受性更好! 好消息!, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Fri Nov 20 16:45:19 CST 2020, time=2020-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=900716, encodeId=2001900e16cd, content=老年人是亮点!, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210703/9c448fe1b3b54fd7bc9477662f4861bb/4bdadad22bfd46f2921aabb4c40265d3.jpg, createdBy=a8d81938466, createdName=weigq, createdTime=Fri Nov 20 09:11:43 CST 2020, time=2020-11-20, status=1, ipAttribution=)]
    2020-11-30 ms9000001337953714

    很有意义

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1724162, encodeId=e0a71e24162bf, content=<a href='/topic/show?id=f9cfe09905f' target=_blank style='color:#2F92EE;'>#病毒载体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70990, encryptionId=f9cfe09905f, topicName=病毒载体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ebd533571600, createdName=ewsr12, createdTime=Sat Sep 25 12:40:46 CST 2021, time=2021-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1702881, encodeId=4bf81e0288134, content=<a href='/topic/show?id=1edc10330893' target=_blank style='color:#2F92EE;'>#黑猩猩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103308, encryptionId=1edc10330893, topicName=黑猩猩)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0b2b30431820, createdName=budeshao, createdTime=Mon Jan 25 01:40:46 CST 2021, time=2021-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1830907, encodeId=1f8f183090e64, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Thu May 20 18:40:46 CST 2021, time=2021-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1645489, encodeId=13d316454892f, content=<a href='/topic/show?id=db329364360' target=_blank style='color:#2F92EE;'>#载体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93643, encryptionId=db329364360, topicName=载体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=58cb23213384, createdName=mei539, createdTime=Wed Dec 02 19:40:46 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=903663, encodeId=e159903663e1, content=很有意义, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0455435910, createdName=ms9000001337953714, createdTime=Mon Nov 30 21:50:33 CST 2020, time=2020-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902998, encodeId=f7c4902998aa, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0085434907, createdName=ms7000000052289295, createdTime=Sat Nov 28 09:47:26 CST 2020, time=2020-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901071, encodeId=b4c89010e118, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=463f5433909, createdName=ms5000002033338938, createdTime=Sat Nov 21 23:07:21 CST 2020, time=2020-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1400251, encodeId=a9bd140025177, content=<a href='/topic/show?id=10cc2901458' target=_blank style='color:#2F92EE;'>#免疫应答#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29014, encryptionId=10cc2901458, topicName=免疫应答)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7a602256775, createdName=clmlylxy, createdTime=Sat Nov 21 11:40:46 CST 2020, time=2020-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=900853, encodeId=b5a99008534c, content=老年人耐受性更好! 好消息!, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Fri Nov 20 16:45:19 CST 2020, time=2020-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=900716, encodeId=2001900e16cd, content=老年人是亮点!, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210703/9c448fe1b3b54fd7bc9477662f4861bb/4bdadad22bfd46f2921aabb4c40265d3.jpg, createdBy=a8d81938466, createdName=weigq, createdTime=Fri Nov 20 09:11:43 CST 2020, time=2020-11-20, status=1, ipAttribution=)]
    2020-11-28 ms7000000052289295

    学习了

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1724162, encodeId=e0a71e24162bf, content=<a href='/topic/show?id=f9cfe09905f' target=_blank style='color:#2F92EE;'>#病毒载体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70990, encryptionId=f9cfe09905f, topicName=病毒载体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ebd533571600, createdName=ewsr12, createdTime=Sat Sep 25 12:40:46 CST 2021, time=2021-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1702881, encodeId=4bf81e0288134, content=<a href='/topic/show?id=1edc10330893' target=_blank style='color:#2F92EE;'>#黑猩猩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103308, encryptionId=1edc10330893, topicName=黑猩猩)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0b2b30431820, createdName=budeshao, createdTime=Mon Jan 25 01:40:46 CST 2021, time=2021-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1830907, encodeId=1f8f183090e64, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Thu May 20 18:40:46 CST 2021, time=2021-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1645489, encodeId=13d316454892f, content=<a href='/topic/show?id=db329364360' target=_blank style='color:#2F92EE;'>#载体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93643, encryptionId=db329364360, topicName=载体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=58cb23213384, createdName=mei539, createdTime=Wed Dec 02 19:40:46 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=903663, encodeId=e159903663e1, content=很有意义, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0455435910, createdName=ms9000001337953714, createdTime=Mon Nov 30 21:50:33 CST 2020, time=2020-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902998, encodeId=f7c4902998aa, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0085434907, createdName=ms7000000052289295, createdTime=Sat Nov 28 09:47:26 CST 2020, time=2020-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901071, encodeId=b4c89010e118, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=463f5433909, createdName=ms5000002033338938, createdTime=Sat Nov 21 23:07:21 CST 2020, time=2020-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1400251, encodeId=a9bd140025177, content=<a href='/topic/show?id=10cc2901458' target=_blank style='color:#2F92EE;'>#免疫应答#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29014, encryptionId=10cc2901458, topicName=免疫应答)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7a602256775, createdName=clmlylxy, createdTime=Sat Nov 21 11:40:46 CST 2020, time=2020-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=900853, encodeId=b5a99008534c, content=老年人耐受性更好! 好消息!, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Fri Nov 20 16:45:19 CST 2020, time=2020-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=900716, encodeId=2001900e16cd, content=老年人是亮点!, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210703/9c448fe1b3b54fd7bc9477662f4861bb/4bdadad22bfd46f2921aabb4c40265d3.jpg, createdBy=a8d81938466, createdName=weigq, createdTime=Fri Nov 20 09:11:43 CST 2020, time=2020-11-20, status=1, ipAttribution=)]
    2020-11-21 ms5000002033338938

    不错

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1724162, encodeId=e0a71e24162bf, content=<a href='/topic/show?id=f9cfe09905f' target=_blank style='color:#2F92EE;'>#病毒载体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70990, encryptionId=f9cfe09905f, topicName=病毒载体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ebd533571600, createdName=ewsr12, createdTime=Sat Sep 25 12:40:46 CST 2021, time=2021-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1702881, encodeId=4bf81e0288134, content=<a href='/topic/show?id=1edc10330893' target=_blank style='color:#2F92EE;'>#黑猩猩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103308, encryptionId=1edc10330893, topicName=黑猩猩)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0b2b30431820, createdName=budeshao, createdTime=Mon Jan 25 01:40:46 CST 2021, time=2021-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1830907, encodeId=1f8f183090e64, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Thu May 20 18:40:46 CST 2021, time=2021-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1645489, encodeId=13d316454892f, content=<a href='/topic/show?id=db329364360' target=_blank style='color:#2F92EE;'>#载体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93643, encryptionId=db329364360, topicName=载体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=58cb23213384, createdName=mei539, createdTime=Wed Dec 02 19:40:46 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=903663, encodeId=e159903663e1, content=很有意义, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0455435910, createdName=ms9000001337953714, createdTime=Mon Nov 30 21:50:33 CST 2020, time=2020-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902998, encodeId=f7c4902998aa, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0085434907, createdName=ms7000000052289295, createdTime=Sat Nov 28 09:47:26 CST 2020, time=2020-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901071, encodeId=b4c89010e118, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=463f5433909, createdName=ms5000002033338938, createdTime=Sat Nov 21 23:07:21 CST 2020, time=2020-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1400251, encodeId=a9bd140025177, content=<a href='/topic/show?id=10cc2901458' target=_blank style='color:#2F92EE;'>#免疫应答#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29014, encryptionId=10cc2901458, topicName=免疫应答)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7a602256775, createdName=clmlylxy, createdTime=Sat Nov 21 11:40:46 CST 2020, time=2020-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=900853, encodeId=b5a99008534c, content=老年人耐受性更好! 好消息!, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Fri Nov 20 16:45:19 CST 2020, time=2020-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=900716, encodeId=2001900e16cd, content=老年人是亮点!, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210703/9c448fe1b3b54fd7bc9477662f4861bb/4bdadad22bfd46f2921aabb4c40265d3.jpg, createdBy=a8d81938466, createdName=weigq, createdTime=Fri Nov 20 09:11:43 CST 2020, time=2020-11-20, status=1, ipAttribution=)]
  9. [GetPortalCommentsPageByObjectIdResponse(id=1724162, encodeId=e0a71e24162bf, content=<a href='/topic/show?id=f9cfe09905f' target=_blank style='color:#2F92EE;'>#病毒载体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70990, encryptionId=f9cfe09905f, topicName=病毒载体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ebd533571600, createdName=ewsr12, createdTime=Sat Sep 25 12:40:46 CST 2021, time=2021-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1702881, encodeId=4bf81e0288134, content=<a href='/topic/show?id=1edc10330893' target=_blank style='color:#2F92EE;'>#黑猩猩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103308, encryptionId=1edc10330893, topicName=黑猩猩)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0b2b30431820, createdName=budeshao, createdTime=Mon Jan 25 01:40:46 CST 2021, time=2021-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1830907, encodeId=1f8f183090e64, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Thu May 20 18:40:46 CST 2021, time=2021-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1645489, encodeId=13d316454892f, content=<a href='/topic/show?id=db329364360' target=_blank style='color:#2F92EE;'>#载体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93643, encryptionId=db329364360, topicName=载体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=58cb23213384, createdName=mei539, createdTime=Wed Dec 02 19:40:46 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=903663, encodeId=e159903663e1, content=很有意义, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0455435910, createdName=ms9000001337953714, createdTime=Mon Nov 30 21:50:33 CST 2020, time=2020-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902998, encodeId=f7c4902998aa, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0085434907, createdName=ms7000000052289295, createdTime=Sat Nov 28 09:47:26 CST 2020, time=2020-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901071, encodeId=b4c89010e118, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=463f5433909, createdName=ms5000002033338938, createdTime=Sat Nov 21 23:07:21 CST 2020, time=2020-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1400251, encodeId=a9bd140025177, content=<a href='/topic/show?id=10cc2901458' target=_blank style='color:#2F92EE;'>#免疫应答#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29014, encryptionId=10cc2901458, topicName=免疫应答)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7a602256775, createdName=clmlylxy, createdTime=Sat Nov 21 11:40:46 CST 2020, time=2020-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=900853, encodeId=b5a99008534c, content=老年人耐受性更好! 好消息!, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Fri Nov 20 16:45:19 CST 2020, time=2020-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=900716, encodeId=2001900e16cd, content=老年人是亮点!, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210703/9c448fe1b3b54fd7bc9477662f4861bb/4bdadad22bfd46f2921aabb4c40265d3.jpg, createdBy=a8d81938466, createdName=weigq, createdTime=Fri Nov 20 09:11:43 CST 2020, time=2020-11-20, status=1, ipAttribution=)]
    2020-11-20 Jessica

    老年人耐受性更好! 好消息!

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1724162, encodeId=e0a71e24162bf, content=<a href='/topic/show?id=f9cfe09905f' target=_blank style='color:#2F92EE;'>#病毒载体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70990, encryptionId=f9cfe09905f, topicName=病毒载体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ebd533571600, createdName=ewsr12, createdTime=Sat Sep 25 12:40:46 CST 2021, time=2021-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1702881, encodeId=4bf81e0288134, content=<a href='/topic/show?id=1edc10330893' target=_blank style='color:#2F92EE;'>#黑猩猩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103308, encryptionId=1edc10330893, topicName=黑猩猩)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0b2b30431820, createdName=budeshao, createdTime=Mon Jan 25 01:40:46 CST 2021, time=2021-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1830907, encodeId=1f8f183090e64, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Thu May 20 18:40:46 CST 2021, time=2021-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1645489, encodeId=13d316454892f, content=<a href='/topic/show?id=db329364360' target=_blank style='color:#2F92EE;'>#载体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93643, encryptionId=db329364360, topicName=载体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=58cb23213384, createdName=mei539, createdTime=Wed Dec 02 19:40:46 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=903663, encodeId=e159903663e1, content=很有意义, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0455435910, createdName=ms9000001337953714, createdTime=Mon Nov 30 21:50:33 CST 2020, time=2020-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902998, encodeId=f7c4902998aa, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0085434907, createdName=ms7000000052289295, createdTime=Sat Nov 28 09:47:26 CST 2020, time=2020-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901071, encodeId=b4c89010e118, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=463f5433909, createdName=ms5000002033338938, createdTime=Sat Nov 21 23:07:21 CST 2020, time=2020-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1400251, encodeId=a9bd140025177, content=<a href='/topic/show?id=10cc2901458' target=_blank style='color:#2F92EE;'>#免疫应答#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29014, encryptionId=10cc2901458, topicName=免疫应答)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7a602256775, createdName=clmlylxy, createdTime=Sat Nov 21 11:40:46 CST 2020, time=2020-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=900853, encodeId=b5a99008534c, content=老年人耐受性更好! 好消息!, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Fri Nov 20 16:45:19 CST 2020, time=2020-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=900716, encodeId=2001900e16cd, content=老年人是亮点!, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210703/9c448fe1b3b54fd7bc9477662f4861bb/4bdadad22bfd46f2921aabb4c40265d3.jpg, createdBy=a8d81938466, createdName=weigq, createdTime=Fri Nov 20 09:11:43 CST 2020, time=2020-11-20, status=1, ipAttribution=)]
    2020-11-20 weigq

    老年人是亮点!

    0

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