Carbohydrate Polymers:灵芝减肥、治疗高脂血症有依据

2021-03-06 自由影像之光 MedSci原创

BSGLP可能通过调节炎症、肠道微生物区系和肠道屏障功能而被用作抑制肥胖和高脂血症的益生菌。

灵芝已被证明具有减肥效果。然而,从破壁灵芝孢子中提取的多糖(BSGLP)抗肥胖作用及其机制尚未见报道。浙江中医药大学药学院王兴亚等发表在Carbohydrate Polymers杂志的文章对此进行了研究。

研究发现BSGLP能抑制高脂饮食(HFD)诱导的C57BL/6J小鼠肥胖、高脂血症、炎症和脂肪堆积。BSGLP改善HFD诱导的肠道微生物区系失调,维持肠屏障功能,增加短链脂肪酸产量和GPR43的表达,改善内毒素血症,表现为降低血清脂多糖水平,增加回肠紧密连接蛋白和抗菌肽的表达。粪便微生物区系移植研究证实,BSGLP诱导的微生物区系改变至少在一定程度上是肥胖抑制的原因。此外,补肾灵芝多糖还能显著减轻高脂饲料诱导的脂肪组织TLR4/MyD88/NF-κB信号通路的上调。

BSGLP抑制高脂饮食诱导的肥胖和炎症作用的机制

综上所述,该研究首次表明BSGLP可能通过调节炎症、肠道微生物区系和肠道屏障功能而被用作抑制肥胖和高脂血症的益生菌

原文出处:Sang T , Guo C , Guo D , et al. Suppression of obesity and inflammation by polysaccharide from sporoderm-broken spore of Ganoderma lucidum via gut microbiota regulation[J]. Carbohydrate Polymers, 2021, 256(5717):117594.

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    2021-06-23 anminleiryan
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    2021-11-01 jjjiang0199
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1878364, encodeId=020918e83640f, content=<a href='/topic/show?id=c157696175' target=_blank style='color:#2F92EE;'>#ERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6961, encryptionId=c157696175, topicName=ERS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e93e105, createdName=anminleiryan, createdTime=Wed Jun 23 01:50:47 CST 2021, time=2021-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2036771, encodeId=49e22036e71ad, content=<a href='/topic/show?id=0bd715152b1' target=_blank style='color:#2F92EE;'>#Rate#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15152, encryptionId=0bd715152b1, topicName=Rate)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5319428, createdName=jjjiang0199, createdTime=Mon Nov 01 14:50:47 CST 2021, time=2021-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1791440, encodeId=d82f1e91440f8, content=<a href='/topic/show?id=6546144e38b' target=_blank style='color:#2F92EE;'>#polymer#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14473, encryptionId=6546144e38b, topicName=polymer)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8e0333, createdName=zhangyxzsh, createdTime=Sat Aug 07 12:50:47 CST 2021, time=2021-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1338498, encodeId=b1151338498e0, content=<a href='/topic/show?id=767711566a9' target=_blank style='color:#2F92EE;'>#MERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11566, encryptionId=767711566a9, topicName=MERS)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/71tKRib0PibveVjnEa7tPLMaCzoKicFlKSEOzRTGf4wNvDV54kJyNx1ott1D5Xp5gRu7IwUia77oN0YFdffvQMu6Ug/132, createdBy=9e302500146, createdName=ms49895894946433513521, createdTime=Mon Mar 08 02:50:47 CST 2021, time=2021-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1574664, encodeId=23e215e4664a9, content=<a href='/topic/show?id=9b56102616bb' target=_blank style='color:#2F92EE;'>#高脂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102616, encryptionId=9b56102616bb, topicName=高脂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c3b716021149, createdName=pcw111, createdTime=Mon Mar 08 02:50:47 CST 2021, time=2021-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=946087, encodeId=550f94608efb, content=还没有临床研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=51784848823, createdName=144422eem17暂无昵称, createdTime=Sun Mar 07 08:06:25 CST 2021, time=2021-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048357, encodeId=3711104835e94, content=什么时候有懒人用的减肥神药?, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Sat Mar 06 14:50:47 CST 2021, time=2021-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945944, encodeId=e66d94594401, content=<a href='/topic/show?id=9df266946f9' target=_blank style='color:#2F92EE;'>#灵芝#</a>仙药哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66946, encryptionId=9df266946f9, topicName=灵芝)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=小小医者, createdTime=Sat Mar 06 14:30:23 CST 2021, time=2021-03-06, status=1, ipAttribution=)]
    2021-03-08 pcw111
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    2021-03-07 144422eem17暂无昵称

    还没有临床研究

    0

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    2021-03-06 CHANGE

    什么时候有懒人用的减肥神药?

    0

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    2021-03-06 小小医者

    #灵芝#仙药哦

    0

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