Can J Cardiol:RIPC可减少高敏肌钙蛋白T和前b型钠尿肽的漏出,为非心脏血管手术患者提供心脏保护

2020-11-14 MedSci原创 MedSci原创

本研究旨在评价远程缺血预处理(RIPC)对预防血管手术患者心脏损伤生物标志物泄漏的影响,研究结果已在线发表于Can J Cardiol。

本研究旨在评价远程缺血预处理(RIPC)对预防血管手术患者心脏损伤生物标志物泄漏的影响,研究结果已在线发表于Can J Cardiol。
 
 
这是一项随机,假对照,双盲,单中心研究,招募接受开腹主动脉瘤修补术、外科下肢血管重建手术或颈动脉内膜切除术的患者。应用RIPC方案,包括4个周期5分钟的缺血,然后5分钟的再灌注。在准备麻醉的同时,无创地进行RIPC或假手术。术前及术后2、8、24小时测定高敏肌钙蛋白T水平,术前及术后24小时测定原b型钠尿肽。
 
结果显示,与RIPC组相比,假手术组的高敏肌钙蛋白T(峰值变化中位数为2 ng/L,IQR 0.9-6.2 ng/L vs 0.6 ng/L,IQR 0.7-2.1 ng/L,p = .0002)和原b型钠尿肽(峰值变化中位数为144 pg/mL,IQR 17-318 pg/mL vs 51 pg/mL,IQR 12-196 pg/mL,p = .02)的漏检率明显较高。
 
 
综上所述,该研究结果表明,RIPC可减少高敏肌钙蛋白T和前b型钠尿肽的漏出。因此,它可以为非心脏血管手术患者提供心脏保护。RIPC的临床意义有待于排除已知影响其效果的因素,进行更大规模的研究评估。
 
原始出处:
 
George Makavos, Ignatios Ikonomidis, et al., Effects of Interleukin 17A Inhibition on Myocardial Deformation and Vascular Function in Psoriasis. Can J Cardiol . 2020 Jan;36(1):100-111. doi: 10.1016/j.cjca.2019.06.021.

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JNNP:脑脊液鞘磷脂:一种新的脱髓鞘生物标志物在CIDP和GBS的诊断和治疗中的应用

目的:慢性炎性脱髓鞘性多神经根神经病(CIDP)和格林-巴利综合征(GBS)是获得性免疫介导的神经病变,在临床表现、预后和治疗反应方面具有很强的异质性。它们属于罕见病而且可治疗,早期识别至关重要。作者