JAHA:伴侣逝世与缺血性卒中和脑出血风险的关系

2020-11-17 MedSci原创 MedSci原创

IS和ICH风险的与伴侣逝世存在统计学显著正相关,特别是在短期内。但是,绝对风险差异很小。

据报道,压力会触发卒中,而伴侣逝世可能是一种极度应激事件。然而,先前的研究在丧亲是否与卒中风险有关方面得出了相互矛盾的结果,这可能是由于缺血性卒中(IS)和脑出血(ICH)之间的区分不足所致。近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员使用全国范围内的高质量注册资源,分别探究了丧亲与IS和ICH之间的关联。

该研究队列纳入了伴侣在2002年至2016年期间死亡的所有丹麦人,并以1:2比例在性别、年龄和日历时间上匹配一组同居人作为对照组。研究人员使用Cox比例风险回归估计长达5年的随访期间调整后的风险比(aHRs)和相应的95%CI。

在研究期间,有278758个人经历了伴侣逝世,其中7684人在随后的5年内发生IS(与未丧亲者相比aHR为1.11;95%CI为1.08-1.14),1139人发生ICH(aHR为1.13;95%CI为1.04–1.23)。对于ICH,估计的关联在伴侣逝世后最初30天内趋于增强(aHR为1.66;95%CI为1.06-2.61),尤其是女性(aHR为1.99;95%CI为1.06-3.75)。从绝对数字上来说,伴侣逝世者在30天时IS的累积发生率为0.73人/1000,对照组为0.63人/1000,而ICH的相应为0.13人/1000和0.08人/1000。

由此可见,IS和ICH风险的与伴侣逝世存在统计学显著正相关,特别是在短期内。但是,绝对风险差异很小。

原始出处:

Morten Fenger‐Grøn.et al.Death of a Partner and Risks of Ischemic Stroke and Intracerebral Hemorrhage: A Nationwide Danish Matched Cohort Study.J AM HEART ASSOC.2020.https://www.ahajournals.org/doi/10.1161/JAHA.120.018143

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    2020-11-19 咻凡

    IS和ICH风险的与伴侣逝世存在统计学显著正相关,特别是在短期内。但是,绝对风险差异很小。

    0

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    2020-11-19 zhaohui6731
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    2020-11-18 ms8000001032906359

    学习了

    0

  8. 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    2020-11-18 咻凡

    IS和ICH风险的与伴侣逝世存在统计学显著正相关,特别是在短期内。但是,绝对风险差异很小。

    0

  9. 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    2020-11-18 一洼菜地

    学习了

    0

  10. 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    2020-11-18 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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TST试验显示,在2860例伴有脑血管粥样硬化性狭窄的缺血性卒中患者中,将低密度脂蛋白胆固醇浓度控制在70 mg/dL以下可降低主要心血管事件风险。但该策略对颈动脉粥样硬化演变的影响尚不明确

J INTERN MED:痴呆患者服用钙通道阻滞剂与生存率和缺血性卒中之间的关系

对于AD和DLB-PDD的痴呆患者服用氨氯地平可降低死亡风险。与其他CCB使用者相比,使用氨氯地平的AD患者发生缺血性卒中的风险较低。