Aging Cell:中药成分盐酸番茄碱可以稳定基因组,缓解早衰

2021-01-21 haibei MedSci原创

最近,研究人员在Aging Cell发文证明,通过衰老相关β-半乳糖苷酶(SA-β-gal)染色和p16、p21的表达作为指征,盐酸番茄碱可以显著抑制压力诱导的细胞过早衰老(SIPS)约2倍。

番茄红素是一种药理活性生物碱,广泛存在于茄科植物中。越来越多的证据表明,植物提取的番茄碱具有多样化的药理功能,如抗病毒、抗菌、抗寄生虫、抗炎和抗肿瘤作用。番茄碱多种功能的分子机制包括诱导细胞凋亡、抑制细胞周期进展和自噬。

盐酸番茄碱作为药材Lycoris radiata的主要活性成分,具有与番茄碱相似的特性,包括抗肿瘤作用。番茄碱和盐酸番茄碱的另一个关键特征是对正常细胞的低毒性。越来越多的证据还表明,番茄碱可能具有治疗年龄相关的阿尔茨海默病的潜力。

然而,番茄碱是否参与延缓细胞衰老的发生及其潜在机制尚未确定。最近,研究人员在Aging Cell发文证明,通过衰老相关β-半乳糖苷酶(SA-β-gal)染色和p16、p21的表达作为指征,盐酸番茄碱可以显著抑制压力诱导的细胞过早衰老(SIPS)约2倍。此外,用盐酸番茄碱预处理细胞可显著抑制SIPS细胞中衰老相关分泌表型(SASP)CXCL1和IL1α的表达。

进一步的实验表明,盐酸番茄碱能促进DNA双链断裂(DSB)修复的同源重组(HR)和非同源末端连接(NHEJ)途径

机制研究表明,盐酸番茄碱处理促进了SIRT1和SIRT6的转录,SIRT1和SIRT6是正向调控HR和NHEJ修复途径的关键长寿基因,从而刺激DSB修复,稳定基因组。

抑制SIRT1酶的活性,可消除盐酸番茄碱延缓SIPS发生、修复DSB和恢复基因组完整性的保护作用。

综上所述,这项工作表明,盐酸番茄碱可能在治疗年龄相关疾病或通过稳定基因组促进健康衰老方面具有治疗潜力

 

原始出处:

Weina Zhang et al. Lycorine hydrochloride suppresses stress‐induced premature cellular senescence by stabilizing the genome of human cells. Aging Cell (2021). 

 

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1962437, encodeId=5e7b196243ebd, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Wed Dec 01 07:22:50 CST 2021, time=2021-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1797115, encodeId=a8181e9711534, content=<a href='/topic/show?id=3dc7224649a' target=_blank style='color:#2F92EE;'>#中药成分#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22464, encryptionId=3dc7224649a, topicName=中药成分)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04ce158, createdName=lxg951, createdTime=Sun Jul 04 01:22:50 CST 2021, time=2021-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1872133, encodeId=1a1918e213376, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sun Nov 21 22:22:50 CST 2021, time=2021-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1635618, encodeId=0c80163561896, content=<a href='/topic/show?id=4483e0337b9' target=_blank style='color:#2F92EE;'>#番茄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70337, encryptionId=4483e0337b9, topicName=番茄)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=982922501584, createdName=hittouch, createdTime=Sun Jul 18 19:22:50 CST 2021, time=2021-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918829, encodeId=05ea91882966, content=<a href='/topic/show?id=ca3310416203' target=_blank style='color:#2F92EE;'>#盐酸番茄碱#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104162, encryptionId=ca3310416203, topicName=盐酸番茄碱)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Thu Jan 21 21:52:28 CST 2021, time=2021-01-21, status=1, ipAttribution=)]
    2021-12-01 维他命
  2. [GetPortalCommentsPageByObjectIdResponse(id=1962437, encodeId=5e7b196243ebd, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Wed Dec 01 07:22:50 CST 2021, time=2021-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1797115, encodeId=a8181e9711534, content=<a href='/topic/show?id=3dc7224649a' target=_blank style='color:#2F92EE;'>#中药成分#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22464, encryptionId=3dc7224649a, topicName=中药成分)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04ce158, createdName=lxg951, createdTime=Sun Jul 04 01:22:50 CST 2021, time=2021-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1872133, encodeId=1a1918e213376, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sun Nov 21 22:22:50 CST 2021, time=2021-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1635618, encodeId=0c80163561896, content=<a href='/topic/show?id=4483e0337b9' target=_blank style='color:#2F92EE;'>#番茄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70337, encryptionId=4483e0337b9, topicName=番茄)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=982922501584, createdName=hittouch, createdTime=Sun Jul 18 19:22:50 CST 2021, time=2021-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918829, encodeId=05ea91882966, content=<a href='/topic/show?id=ca3310416203' target=_blank style='color:#2F92EE;'>#盐酸番茄碱#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104162, encryptionId=ca3310416203, topicName=盐酸番茄碱)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Thu Jan 21 21:52:28 CST 2021, time=2021-01-21, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1962437, encodeId=5e7b196243ebd, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Wed Dec 01 07:22:50 CST 2021, time=2021-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1797115, encodeId=a8181e9711534, content=<a href='/topic/show?id=3dc7224649a' target=_blank style='color:#2F92EE;'>#中药成分#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22464, encryptionId=3dc7224649a, topicName=中药成分)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04ce158, createdName=lxg951, createdTime=Sun Jul 04 01:22:50 CST 2021, time=2021-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1872133, encodeId=1a1918e213376, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sun Nov 21 22:22:50 CST 2021, time=2021-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1635618, encodeId=0c80163561896, content=<a href='/topic/show?id=4483e0337b9' target=_blank style='color:#2F92EE;'>#番茄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70337, encryptionId=4483e0337b9, topicName=番茄)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=982922501584, createdName=hittouch, createdTime=Sun Jul 18 19:22:50 CST 2021, time=2021-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918829, encodeId=05ea91882966, content=<a href='/topic/show?id=ca3310416203' target=_blank style='color:#2F92EE;'>#盐酸番茄碱#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104162, encryptionId=ca3310416203, topicName=盐酸番茄碱)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Thu Jan 21 21:52:28 CST 2021, time=2021-01-21, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1962437, encodeId=5e7b196243ebd, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Wed Dec 01 07:22:50 CST 2021, time=2021-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1797115, encodeId=a8181e9711534, content=<a href='/topic/show?id=3dc7224649a' target=_blank style='color:#2F92EE;'>#中药成分#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22464, encryptionId=3dc7224649a, topicName=中药成分)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04ce158, createdName=lxg951, createdTime=Sun Jul 04 01:22:50 CST 2021, time=2021-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1872133, encodeId=1a1918e213376, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sun Nov 21 22:22:50 CST 2021, time=2021-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1635618, encodeId=0c80163561896, content=<a href='/topic/show?id=4483e0337b9' target=_blank style='color:#2F92EE;'>#番茄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70337, encryptionId=4483e0337b9, topicName=番茄)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=982922501584, createdName=hittouch, createdTime=Sun Jul 18 19:22:50 CST 2021, time=2021-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918829, encodeId=05ea91882966, content=<a href='/topic/show?id=ca3310416203' target=_blank style='color:#2F92EE;'>#盐酸番茄碱#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104162, encryptionId=ca3310416203, topicName=盐酸番茄碱)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Thu Jan 21 21:52:28 CST 2021, time=2021-01-21, status=1, ipAttribution=)]
    2021-07-18 hittouch
  5. [GetPortalCommentsPageByObjectIdResponse(id=1962437, encodeId=5e7b196243ebd, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Wed Dec 01 07:22:50 CST 2021, time=2021-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1797115, encodeId=a8181e9711534, content=<a href='/topic/show?id=3dc7224649a' target=_blank style='color:#2F92EE;'>#中药成分#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22464, encryptionId=3dc7224649a, topicName=中药成分)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04ce158, createdName=lxg951, createdTime=Sun Jul 04 01:22:50 CST 2021, time=2021-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1872133, encodeId=1a1918e213376, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sun Nov 21 22:22:50 CST 2021, time=2021-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1635618, encodeId=0c80163561896, content=<a href='/topic/show?id=4483e0337b9' target=_blank style='color:#2F92EE;'>#番茄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70337, encryptionId=4483e0337b9, topicName=番茄)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=982922501584, createdName=hittouch, createdTime=Sun Jul 18 19:22:50 CST 2021, time=2021-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918829, encodeId=05ea91882966, content=<a href='/topic/show?id=ca3310416203' target=_blank style='color:#2F92EE;'>#盐酸番茄碱#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104162, encryptionId=ca3310416203, topicName=盐酸番茄碱)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Thu Jan 21 21:52:28 CST 2021, time=2021-01-21, status=1, ipAttribution=)]

相关资讯

PNAS:上海交大发现抗衰老新物质——TPP-噻唑,效果惊人暂无副作用!

上海交通大学药学院傅磊课题组和斯坦福大学的科学家们设计了一类新化合物,2-(2-(4-甲基噻唑-5-基)乙氧基)-2-氧乙基三唑的三苯基膦衍生物(简称TPP-噻唑,是Mito-Fu家族的成员)。这项研

Aging:“重返”年轻有望!新研究发现:稀释血浆便能逆转衰老,恢复组织生机

人类在与衰老的这场“拔河”中,或许真能赢得主动。

PNAS:王晓东团队发现新化合物:保护线粒体,拯救神经疾病!

已知线粒体损伤和细胞死亡与多种神经退行性疾病有关,如帕金森症和中风。

中国衰老与抗衰老专家共识(2019年)

人口老龄化是世界各国亟待解决的问题。中国作为人口大国,人口老龄化问题尤为严重。因此,积极应对人口老龄化,践行“健康中国行动”,既是国家的目标,也是广大科技工作者责无旁贷的使命。为了进一步凝练学科发展的方向,普及全国公众对衰老机制和抗衰老科技进展的认识,指导健康产业的发展,我们在2013 年,首次发布的《中国衰老与抗衰老专家共识》的基础上,结合近年来全球衰老与抗衰老研究的重大成就,达成共识。

Sci Transl Med :刘光慧/汤富酬等开发延长寿命、抗衰老基因疗法

人类基因组中有多少个衰老调控基因?这些基因参与衰老调控的分子机制是什么?能否在分子层面“操控”这些基因以延缓机体的衰老?这些都是衰老研究领域亟待解决的重要科学问题。

CELL METAB:清除衰老细胞不仅不能抗衰老,还有害健康?

衰老细胞的积累可导致许多与年龄相关的表型和病理。因此,有人提出,去除衰老细胞可能会延长寿命。