Eur Urol:放疗复发的高风险前列腺癌的临床进展模式

2021-05-22 AlexYang MedSci原创

超过50%的高风险前列腺癌男性患者 (HRPCa)(格里森4-5级疾病,或者临床T分期3-4级或前列腺特异性抗原(PSA)>20ng/ml)在长期随访中会出现生化复发(BCR)。放疗(RT)后的

超过50%的高风险前列腺癌男性患者 (HRPCa)(格里森4-5级疾病,或者临床T分期3-4级或前列腺特异性抗原(PSA)>20ng/ml)在长期随访中会出现生化复发(BCR)。放疗(RT)后的BCR称为 "放射性复发",目前定义为与RT后最低PSA水平相比上升2ng/ml,并可能存在局部、区域或远处的疾病。治疗的方法包括观察、雄性激素阻断治疗(ADT)、转移靶向治疗和局部抢救性治疗 ,但由于缺乏前瞻性研究和对放射性复发性HRPC本质的了解,治疗方法的选择仍旧没有针对性。 近期,有研究人员评估了HRPCa患者BCR后的临床结果,他们接受了体外放射治疗(EBRT)或 EBRT+BT)治疗。 为了更好地了解其临床过程,研究人员评估了1997年至2015年15家机构的978名放疗复发HRPCa男性患者的远处转移率(DM)和前列腺癌特异性死亡率(PCSM),他们之前接受了外照射放射治疗(EBRT,n=654,67%)或EBRT+近距离治疗(EBRT + BT,n=324,33%)。在没有死亡的男性中,放疗后的随访时间中位数为8.9年,生化复发(BCR)后的随访时间中位数为3.7年。在EB

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1862161, encodeId=57aa186216165, content=<a href='/topic/show?id=a374102813a1' target=_blank style='color:#2F92EE;'>#高风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102813, encryptionId=a374102813a1, topicName=高风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f5e185, createdName=zlawrance, createdTime=Mon Nov 22 07:48:19 CST 2021, time=2021-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=970713, encodeId=73f59e0713c9, content=谈癌色变, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210313/9df56058b3964a8cac82563f95f0389d/c1b478592e8e4463bef44d32712e98fd.jpg, createdBy=ea905324251, createdName=SR~young海东, createdTime=Thu Jun 03 23:14:54 CST 2021, time=2021-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=967825, encodeId=115a96e82562, content=战胜癌症刻不容缓。, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210313/9df56058b3964a8cac82563f95f0389d/c1b478592e8e4463bef44d32712e98fd.jpg, createdBy=ea905324251, createdName=SR~young海东, createdTime=Sat May 22 21:36:15 CST 2021, time=2021-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1041015, encodeId=a840104101557, content=前列腺癌相关研究,学习了,谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sat May 22 16:48:19 CST 2021, time=2021-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=967724, encodeId=387696e724d4, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210522/54a0783967654e629aa9574c834f92a2/cb04eedaebc54b31bd3271f76e99b26c.jpg, createdBy=98265506064, createdName=ms2000001260387519, createdTime=Sat May 22 14:34:25 CST 2021, time=2021-05-22, status=1, ipAttribution=)]
    2021-06-03 SR~young海东

    谈癌色变

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1862161, encodeId=57aa186216165, content=<a href='/topic/show?id=a374102813a1' target=_blank style='color:#2F92EE;'>#高风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102813, encryptionId=a374102813a1, topicName=高风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f5e185, createdName=zlawrance, createdTime=Mon Nov 22 07:48:19 CST 2021, time=2021-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=970713, encodeId=73f59e0713c9, content=谈癌色变, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210313/9df56058b3964a8cac82563f95f0389d/c1b478592e8e4463bef44d32712e98fd.jpg, createdBy=ea905324251, createdName=SR~young海东, createdTime=Thu Jun 03 23:14:54 CST 2021, time=2021-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=967825, encodeId=115a96e82562, content=战胜癌症刻不容缓。, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210313/9df56058b3964a8cac82563f95f0389d/c1b478592e8e4463bef44d32712e98fd.jpg, createdBy=ea905324251, createdName=SR~young海东, createdTime=Sat May 22 21:36:15 CST 2021, time=2021-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1041015, encodeId=a840104101557, content=前列腺癌相关研究,学习了,谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sat May 22 16:48:19 CST 2021, time=2021-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=967724, encodeId=387696e724d4, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210522/54a0783967654e629aa9574c834f92a2/cb04eedaebc54b31bd3271f76e99b26c.jpg, createdBy=98265506064, createdName=ms2000001260387519, createdTime=Sat May 22 14:34:25 CST 2021, time=2021-05-22, status=1, ipAttribution=)]
    2021-05-22 SR~young海东

    战胜癌症刻不容缓。

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1862161, encodeId=57aa186216165, content=<a href='/topic/show?id=a374102813a1' target=_blank style='color:#2F92EE;'>#高风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102813, encryptionId=a374102813a1, topicName=高风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f5e185, createdName=zlawrance, createdTime=Mon Nov 22 07:48:19 CST 2021, time=2021-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=970713, encodeId=73f59e0713c9, content=谈癌色变, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210313/9df56058b3964a8cac82563f95f0389d/c1b478592e8e4463bef44d32712e98fd.jpg, createdBy=ea905324251, createdName=SR~young海东, createdTime=Thu Jun 03 23:14:54 CST 2021, time=2021-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=967825, encodeId=115a96e82562, content=战胜癌症刻不容缓。, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210313/9df56058b3964a8cac82563f95f0389d/c1b478592e8e4463bef44d32712e98fd.jpg, createdBy=ea905324251, createdName=SR~young海东, createdTime=Sat May 22 21:36:15 CST 2021, time=2021-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1041015, encodeId=a840104101557, content=前列腺癌相关研究,学习了,谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sat May 22 16:48:19 CST 2021, time=2021-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=967724, encodeId=387696e724d4, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210522/54a0783967654e629aa9574c834f92a2/cb04eedaebc54b31bd3271f76e99b26c.jpg, createdBy=98265506064, createdName=ms2000001260387519, createdTime=Sat May 22 14:34:25 CST 2021, time=2021-05-22, status=1, ipAttribution=)]
    2021-05-22 misszhang

    前列腺癌相关研究,学习了,谢谢梅斯

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1862161, encodeId=57aa186216165, content=<a href='/topic/show?id=a374102813a1' target=_blank style='color:#2F92EE;'>#高风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102813, encryptionId=a374102813a1, topicName=高风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f5e185, createdName=zlawrance, createdTime=Mon Nov 22 07:48:19 CST 2021, time=2021-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=970713, encodeId=73f59e0713c9, content=谈癌色变, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210313/9df56058b3964a8cac82563f95f0389d/c1b478592e8e4463bef44d32712e98fd.jpg, createdBy=ea905324251, createdName=SR~young海东, createdTime=Thu Jun 03 23:14:54 CST 2021, time=2021-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=967825, encodeId=115a96e82562, content=战胜癌症刻不容缓。, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210313/9df56058b3964a8cac82563f95f0389d/c1b478592e8e4463bef44d32712e98fd.jpg, createdBy=ea905324251, createdName=SR~young海东, createdTime=Sat May 22 21:36:15 CST 2021, time=2021-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1041015, encodeId=a840104101557, content=前列腺癌相关研究,学习了,谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sat May 22 16:48:19 CST 2021, time=2021-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=967724, encodeId=387696e724d4, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210522/54a0783967654e629aa9574c834f92a2/cb04eedaebc54b31bd3271f76e99b26c.jpg, createdBy=98265506064, createdName=ms2000001260387519, createdTime=Sat May 22 14:34:25 CST 2021, time=2021-05-22, status=1, ipAttribution=)]
    2021-05-22 ms2000001260387519

    0

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