Cell Death Dis:SIK2能够通过PI3K/Akt信号增加脂肪酸及胆固醇合成促进卵巢癌生长

2020-02-13 QQY MedSci原创

盐诱导激酶2 (SIK2)已经被证实是多种生物过程包括细胞代谢的调节因子。近期,一项研究报道,SIK2通过促进脂肪酸氧化作用,对脂肪细胞诱导的卵巢癌(OC)生存是必需的。但SIK2是否也在OC细胞的脂质合成过程中也发挥作用尚不明确。本研究发现,在OC细胞中,SIK2能够显著促进脂质合成。一方面,SIK2可以通过上调固醇调节元件结合蛋白1c(SREBP1c)的表达并影响主要脂肪生成酶FASN的转录进

盐诱导激酶2 (SIK2)已经被证实是多种生物过程包括细胞代谢的调节因子。近期,一项研究报道,SIK2通过促进脂肪酸氧化作用,对脂肪细胞诱导的卵巢癌(OC)生存是必需的。但SIK2是否也在OC细胞的脂质合成过程中也发挥作用尚不明确。

本研究发现,在OC细胞中,SIK2能够显著促进脂质合成。一方面,SIK2可以通过上调固醇调节元件结合蛋白1c(SREBP1c)的表达并影响主要脂肪生成酶FASN的转录进而增强脂肪酸的合成。而另一方面,SIK2可以通过上调固醇调节元件结合蛋白2(SREBP2)的表达,从而上调大脂酶HMGCR的转录,进而促进脂肪酸合成。

此外,在OC细胞中,PI3K/Akt信号通路还参与上调SREBP1c和SREBP2的表达水平。体内外实验也同样证实了SIK2调节的脂肪酸和胆固醇合成在OC细胞的生长过程中起着至关重要的作用。

综上所述,该研究主要发现了SIK2是OC细胞中脂质合成的一个关键调节因子,其能够促进OC细胞生长,为该分子作为卵巢癌的潜在治疗靶点提供了有力的证据。

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    2020-07-19 维他命
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    2020-12-16 docwu2019
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href='/topic/show?id=ecfa1423117' target=_blank style='color:#2F92EE;'>#PI3K#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14231, encryptionId=ecfa1423117, topicName=PI3K)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/BF4BC9769C2FF12AC93CAA0069C0696C/100, createdBy=7bb22500091, createdName=ms1292405679162969, createdTime=Sat Feb 15 13:11:00 CST 2020, time=2020-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1531538, encodeId=4fe2153153830, content=<a href='/topic/show?id=770e5e9457' target=_blank style='color:#2F92EE;'>#Death#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5794, encryptionId=770e5e9457, topicName=Death)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32e312278742, createdName=cy0328, createdTime=Sat Feb 15 13:11:00 CST 2020, time=2020-02-15, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1961873, encodeId=3c4c19618e3a1, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Sun Jul 19 01:11:00 CST 2020, time=2020-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1656190, encodeId=cd7516561902a, content=<a href='/topic/show?id=f4782246ec' target=_blank style='color:#2F92EE;'>#Akt#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2246, encryptionId=f4782246ec, topicName=Akt)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, 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href='/topic/show?id=ecfa1423117' target=_blank style='color:#2F92EE;'>#PI3K#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14231, encryptionId=ecfa1423117, topicName=PI3K)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/BF4BC9769C2FF12AC93CAA0069C0696C/100, createdBy=7bb22500091, createdName=ms1292405679162969, createdTime=Sat Feb 15 13:11:00 CST 2020, time=2020-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1531538, encodeId=4fe2153153830, content=<a href='/topic/show?id=770e5e9457' target=_blank style='color:#2F92EE;'>#Death#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5794, encryptionId=770e5e9457, topicName=Death)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32e312278742, createdName=cy0328, createdTime=Sat Feb 15 13:11:00 CST 2020, time=2020-02-15, status=1, ipAttribution=)]
    2020-05-22 lidong40
  6. 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createdBy=32e312278742, createdName=cy0328, createdTime=Sat Feb 15 13:11:00 CST 2020, time=2020-02-15, status=1, ipAttribution=)]
    2020-12-15 oliver169
  7. 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createdBy=32e312278742, createdName=cy0328, createdTime=Sat Feb 15 13:11:00 CST 2020, time=2020-02-15, status=1, ipAttribution=)]
  8. 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    2020-02-15 cy0328

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