ARCH PATHOL LAB MED：原发性眼附属器边缘区淋巴瘤MYD88 L265P高频率突变及其临床病理相关性研究

2019-05-09 不详网络

原发性眼附件边缘区淋巴瘤(POAMZL)的发病机制尚不清楚。之前有研究报导报道与psittaci衣原体感染和MYD88突变的有关。本研究目的是检测MYD88 L265P在眼缘区淋巴瘤中的突变，并探讨其与临床病理特征及衣原体感染的关系。

原发性眼附件边缘区淋巴瘤(POAMZL)的发病机制尚不清楚。之前有研究报导报道与psittaci衣原体感染和MYD88突变的有关。本研究目的是检测MYD88 L265P在眼缘区淋巴瘤中的突变，并探讨其与临床病理特征及衣原体感染的关系。

采用敏感聚合酶链反应(PCR)方法分析淋巴瘤中MYD88 L265P突变及衣原体感染情况。研究发现22个POAMZLs中有8个(36%)检测到MYD88 L265P突变，其中3例病例中有2例PCR检测不出克隆IGH基因重排；4例继发性边缘区淋巴瘤均无阳性。所有病例衣原体检测结果均为阴性。有无MYD88突变的患者具有相似的临床病理特征。

MYD88突变分析为POAMZL的诊断提供了重要信息。MYD88的频繁突变提示这种异常在POAMZL的发病机制中起着重要作用，并可能成为进展性疾病患者的治疗靶点。

原始出处：

Amir Behdad, MD; Xiao Yi Zhou, MD;High Frequency of MYD88 L265P Mutation in Primary Ocular Adnexal Marginal Zone Lymphoma and Its Clinicopathologic Correlation: A Study From a Single Institution

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2019-09-21 jiyangfei

#原发性#

36 0
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2020-04-21 shenxlcyp

#相关性#

33 0
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2019-09-26 cmj8wellington

#临床病理#

32 0
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2019-07-19 yb6560

#Pathol#

28 0
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2019-05-11 zhouqu_8

#边缘区淋巴瘤#

41 0
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2019-05-11 肉我只吃一口

#MYD88#

39 0
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2019-05-11 ms3994565386320060

#Med#

19 0
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2019-05-09 王秀

学习了，涨知识了！

75 0

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