如何治疗继发于阿达木单抗功效丧失的化脓性汗腺炎?可选择Ixekizumab

2020-11-08 Allan MedSci原创

根据在第29届欧洲皮肤病与性病学会大会上发表的一项小型研究,Ixekizumab能够恢复化脓性水肿性汗腺炎。

根据在第29届欧洲皮肤病与性病学会大会上发表的一项小型研究,Ixekizumab能够恢复化脓性水肿性汗腺炎。德国汉堡大学医学中心的Caroline Hilbring说:“尽管该研究仅包括10名患者,但首次评估的结果是有希望的。根据我们在牛皮癣和其他慢性炎症性疾病中的经验,需要选择更多的靶向疗法,尤其是在继发性疾病方面”。

该研究中的所有化脓性汗腺炎患者(9名女性,1名男性)均已接受基于指南的系统性抗生素和阿达木单抗治疗,但随着时间的推移,患者对阿达木单抗治疗的反应有所降低。所有10名患者每2周接受ixekizumab 80 mg治疗3个月,然后每4周接受80 mg。在治疗4周和16周后评估治疗反应。

总体而言,国际平均化脓性汗腺炎严重程度(IHS4)分数从基线的13.6降低至第16周的9.6。平均皮肤病生活质量指数(DLQI)也显示从基线的11.7下降到第16周的7.8。

 

原始出处:

https://www.firstwordpharma.com/node/1771693?tsid=4

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    2021-03-12 feifers
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    2021-06-08 snf701207
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    2020-11-10 ms5000002087413465

    学习了

    0

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第三款国产阿达木单抗价格公布

信达生物的第三款国产阿达木单抗(商品名为苏立信)价格公布—市场售价为1150元/瓶。同时,苏立信的赠药政策也首次公开,信达生物将拿出12000支苏立信用于该援助项目,低收入患者可以享受买4赠2的赠药援

J Rheumatol:银屑病关节炎患者药理生物标志物与治疗反应和长期残疾的关联

检测ADA初治PsA患者的药物水平有助于确定12个月内的治疗反应/残疾。

原研全人源阿达木单抗获批新适应症,为克罗恩病患者带来新的曙光!

克罗恩病是一种炎症性肠病,典型症状包括慢性腹泻、腹痛、体重减轻、食欲减退、发热、直肠出血,这些都影响患者个人的生活质量。克罗恩病包括一系列的临床和病理过程,表现为可累及胃肠道任何部分的局灶性非对称透壁性炎症,有时伴肉芽肿形成,该病主要影响回肠和结肠。中重度疾病的临床特征包括可阻塞肠道的狭窄、脓肿和瘘管。在我国,克罗恩病患病率为2.29例/10万人,发病率为0.848例/10万人。随着时间的推移,中

“药王”阿达木单抗再遇劲敌:生物仿制药AVT02取得积极结果

Alvotech制药公司今日宣布,两项针对AVT02的研究已达到其主要目标。

Ann Rheum Dis:阿达木单抗血清水平和抗体对下一种bDMARD的治疗反应没有预测价值

与早期研究相反,这项研究没有找到ADA或随机ADL对转换为TNFi或非TNFi后治疗反应的预测价值。

拓展阅读

NEJM Evid:三种潜在治疗方案治疗化脓性汗腺炎

突破性研究:三种潜在治疗方案对抗患者患处于中重度HS的挑战

AAD 2024:母亲患有化脓性汗腺炎可能会增加后代住院风险

有研究显示,HS与不良妊娠结局有关,但对后代结局的影响尚不清楚。本研究旨在比较患有 HS 和未患 HS 母亲对其后代的影响。

AAD 2024:新型药物有望治疗中重度化脓性汗腺炎

该研究评估了高选择性口服BTK抑制剂remibrutinib的安全性和疗效。

Front Immunol:炎症性肠病和化脓性汗腺炎之间的因果关系

IBD及其亚型对HS有因果效应,而HS对IBD无影响。肠-皮肤轴的相互作用可能有助于理解这一关联。然而,IBD与HS因果关系的病理生理学机制仍需进一步研究。

Front Immunol:遗传预测的循环细胞因子水平和六种免疫性皮肤病的风险: 一项两样本孟德尔随机化研究

12种独特的细胞因子与6种免疫性皮肤病的发病风险存在提示的因果关系。

JAMA Dermatol:定量感觉测试表征化脓性汗腺炎皮损感觉变化

HS涉及皮肤或其游离神经末梢的局部改变,可能导致周围神经病变以及非伤害性或伤害性温度和机械性刺激的转导改变。