Cell Death Dis:抑制甲状腺激素信号通路或可用于治疗老年性黄斑变性

2020-02-09 QQY MedSci原创

老年性黄斑变性(AMD)是老年人失明的主要原因。干性AMD的主要特征表现为视网膜色素上皮(RPE)和感光细胞逐渐发生黄斑变性,且该疾病的核心问题为RPE细胞的氧化性损伤或营养不良。最近基于正常人群及患者的研究表明,高游离血清甲状腺激素(TH)水平与AMD风险升高息息相关。该研究发现,在氧化应激诱导AMD的小鼠模型中,抑制TH信号能够引起RPE细胞及感光细胞的损伤/细胞死亡。通过抗甲状腺药物治疗及碘

老年性黄斑变性(AMD)是老年人失明的主要原因。干性AMD的主要特征表现为视网膜色素上皮(RPE)和感光细胞逐渐发生黄斑变性,且该疾病的核心问题为RPE细胞的氧化性损伤或营养不良。

最近基于正常人群及患者的研究表明,高游离血清甲状腺激素(TH)水平与AMD风险升高息息相关。该研究发现,在氧化应激诱导AMD的小鼠模型中,抑制TH信号能够引起RPE细胞及感光细胞的损伤/细胞死亡。

通过抗甲状腺药物治疗及碘化钠(NaIO3)诱导氧化应激可抑制TH信号。NaIO3处理的小鼠表现出严重的RPE细胞及感光细胞死亡/坏死、解构、氧化损伤、视网膜应激反应及视网膜功能减退。

使用抗甲状腺药物治疗可以保护RPE细胞及感光细胞免受NaIO3诱导的损伤/细胞死亡,并且减少RPE细胞及感光细胞的氧化损伤,维持视网膜的正常功能。

基因表达分析表明,NaIO3诱导的RPE细胞及感光细胞损伤/细胞死亡涉及多种机制,包括细胞的氧化应激反应、细胞坏死/凋亡信号的激活和炎症反应。抗甲状腺药物治疗能够消除这些细胞应激及死亡反应。

该研究结果证实了TH信号在RPE和氧化应激后感光细胞死亡中的作用,证实了TH信号在AMD发病机制中的作用。

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    2021-06-09 147d8889m87暂无昵称

    好文章,多学习

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    2020-08-27 维他命
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    2020-02-11 huangdf
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    2020-02-11 muzishouyi
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    2020-02-11 cy0328
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