Clin Nutrition:术后早期肠内免疫营养对T淋巴细胞计数的改善效果分析

2021-02-22 MedSci原创 MedSci原创

心脏外科手术患者,尤其是在体外循环下进行的外科手术患者,会经历不同的对各种生理功能的负面影响。

      心脏外科手术患者,尤其是在体外循环下进行的外科手术患者,会经历不同的对各种生理功能的负面影响,例如灌注不足,继而发生器官功能障碍,体温过低,组织损伤等,由此导致细胞免疫力降低。免疫调节营养补充剂被认为对于接受大手术的患者大有裨益。但是,由于缺乏心脏外科手术人群的研究,在该患者组中免疫营养的作用仍不清楚。因此,本项研究旨在探究心脏手术人群术后早期肠内免疫营养对T淋巴细胞计数的疗效。

 

 

      研究人员对接受择期心脏手术的低手术风险成人患者进行了随机对照研究。这些患者被随机分为免疫营养组和对照组。免疫营养组在术后五天补充了免疫营养制剂。同时对患者手术当天和术后第六天进行T淋巴细胞的计数以及CD4+和CD4+细胞亚群的计数以判断两组患者之间的差异。

 

 

      该研究纳入了55位患者,平均年龄为69.7±6.3岁,其中28位(50.9%)为男性。二十七位患者(49.1%)被随机分为免疫营养组。免疫营养组术后第6天CD3+ T细胞和CD4+ T细胞的计数明显高于对照组,分别为1.42±0.49和1.12±0.56(* 10 9/l),p = 0.035和1.02 ±0.36与0.80±0.43(* 109/l),p = 0.048。进行回归分析发现CD3+ T和CD4+ T细胞计数分别增加0.264(* 109/l),p = 0.039和0.232(* 109/l),p = 0.021。

 

     

      因此,作者最后说道术后早期的免疫营养会增加心脏外科手术患者CD3 +和CD4 + T细胞的数量,进而改善患者免疫力。

 

 

原始出处:

Marija Svetikiene. Et al. The efficacy of early postoperative enteral immunonutrition on T-lymphocyte count: A randomised control study in low-risk cardiac surgery patients. Clinical Nutrition.2021.

 

 

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    2021-05-17 ms5000000763415338

    尤其是蛋白增加能显著提高免疫力

    0

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    2021-02-23 CHANGE

    疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的

    0

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