急性骨髓炎抗生素静脉改口服时间点

2014-01-29 cmt 医学论坛网

急性骨髓炎通常会诱发严重的临床后果,重者可能会至患儿死亡,为减少这种可能性,临床上在急性骨髓炎患儿治疗早期应用静脉抗生素治疗,在患儿接近康复时转为口服抗生素。但很少有临床医生意识到,在1930年末期口服磺胺类抗生素就可以有效的治疗急性骨髓炎患者。 近些年抗生素的种类及抗菌谱得到了极大的发展,其治疗策略也发生了重大变化,静脉使用抗生素治疗急性骨髓炎已经成为一种临床习惯,但参考数十年前的抗生素治

急性骨髓炎通常会诱发严重的临床后果,重者可能会至患儿死亡,为减少这种可能性,临床上在急性骨髓炎患儿治疗早期应用静脉抗生素治疗,在患儿接近康复时转为口服抗生素。但很少有临床医生意识到,在1930年末期口服磺胺类抗生素就可以有效的治疗急性骨髓炎患者。

近些年抗生素的种类及抗菌谱得到了极大的发展,其治疗策略也发生了重大变化,静脉使用抗生素治疗急性骨髓炎已经成为一种临床习惯,但参考数十年前的抗生素治疗策略,治疗早期即开始口服抗生素并不会产生不良后果。问题是,早期口服的早期时间点在哪。

目前有三个研究证明,对急性骨髓炎患者,静脉抗生素使用持续小于1周并不会显著改变临床功能预后。一项英国完成的系统回顾发现,短期肠道外给药治疗无并发症的骨髓炎疗效可靠。作者对131例免疫完整的年龄大于3月的患儿治疗中发现,静脉治疗2-4天,后改为口服治疗,骨髓炎后期无明显复发。但是该结论对MRSA患者不适用。对MRSA感染较为严重的地区,如美国,更加保守的抗生素治疗策略可能相对合适,但需要后期临床研究进一步明确。


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    2014-06-27 fusion
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    2014-01-31 宋威