J Endod:预处理牙本质基质异种移植物在牙髓牙本质组织工程中应用的潜力

2019-11-30 lishiting MedSci原创

这篇研究的目的是为了研发和检测一种脱肽处理的牙本质基质异种移植物在体内和体外模型中的再生潜力。

这篇研究的目的是为了研发和检测一种脱肽处理的牙本质基质异种移植物在体内和体外模型中的再生潜力。

研究将新鲜拔除的牛牙本质粉碎为250-至500-μm之间大小的微粒,并使用17% EDTA分别脱矿1, 7和13天。样本使用蛋白酶进行脱肽处理。分别采用场发射SEM结合能量分散X线分光镜检查和傅里叶变换红外光谱评估脱矿的程度以及脱肽的效果。采用实时定量聚合酶链式反应检测牙髓干细胞中牙本质基质酸性磷蛋白1,牙本质涎磷蛋白和骨桥蛋白的表达水平。随后将样本植入大鼠肌肉30天,组织学定量分析炎症细胞的数量。

场发射SEM结合能量分散X线分光镜检查结果显示,脱矿1和7天,牙本质出现暴露的管状结构。傅里叶变换红外光谱验证了脱肽后在1260至1640 / cm之间不存在酰胺峰。与对照组相比,所有组中牙本质基质酸性磷蛋白1和牙本质涎磷蛋白的表达均明显增加(P < .05)。在脱矿和脱肽1天组中,表达比例最高。与7或13天脱矿组相比,1天脱矿组展现出最高的炎症反应(P < .001)。脱肽仅在1天脱矿牙本质组中展现出显著抑制炎症反应的效果(P < .05)。

结论:脱矿和脱肽1天的牙本质异种移植物存在胶原结构、最小化的免疫反应并具有足够的再生潜力。

原始出处:

Bakhtiar H, Mazidi A, et al. Potential of Treated Dentin Matrix Xenograft for Dentin-Pulp Tissue Engineering. J Endod. 2019 Nov 20. pii: S0099-2399(19)30741-1. doi: 10.1016/j.joen.2019.10.005.

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    2020-10-10 xuyong535
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