Front. Aging Neurosci:认知正常的老年人中与阿尔茨海默病相关的标志物与体育活动水平有关

2022-05-22 影像小生 MedSci原创

在认知正常的老年人中,体育活动和脑淀粉样蛋白沉积以及潜在的AD血液生物标志物之间存在复杂的关系。

体育活动可能有助于降低患阿尔茨海默病(AD)的风险,尽管其潜在机制尚不完全清楚。高水平的体育活动是一种生活方式因素,可以防止AD病理的发展,此外,还可以减缓脑萎缩和相关的进行性认知衰退。动物研究的大量证据支持运动在降低大脑水平方面的作用。在这项动物研究的基础上,一些来自人类研究的报告将较高水平的体育活动与较低的脑淀粉样蛋白沉积联系起来,这些研究使用淀粉样蛋白结合配体在PET下进行测量。正如预期的那样,在认知健康的成年人中,脑脊液相关的生物标志物也受到体育活动的影响。

Steve Pedrini等在Front. Aging Neurosci杂志发表研究文章,评估(APOE) ε4携带者和非携带者中习惯性体育活动水平与脑淀粉样沉积和AD相关血液生物标志物之间的关系。

该研究评估了143名认知正常的老年人,所有人的大脑淀粉样蛋白沉积均使用正电子发射断层扫描进行评估,并使用国际体育活动问卷(IPAQ)测量了他们的体育活动水平。

该研究发现:

低到中度体力活动(LMPA)和高体力活动(HPA)组血浆生物标志物的比较

低到中度体力活动(LMPA)和高体力活动(HPA)组血浆生物标志物比值的比较

全研究参与者和经体育活动水平分层后脑淀粉样负荷与血液生物标志物水平的相关性

1.     脑淀粉样变与血浆β -淀粉样蛋白(Aβ) 1-42呈负相关,但未发现脑淀粉样变与血浆Aβ1-40和淀粉样前体蛋白(APP)669-711相关。

2.     较高的体力活动水平与APOE ε4非携带者血浆Aβ1-40Aβ1-42APP669-711水平相关。

3.     与高脑淀粉样变相关的Aβ1-40/Aβ1-42和APP669-711/Aβ1-42的比值在APOE ε4携带者和非携带者之间存在差异。

综上所述,在认知正常的老年人中,体育活动和脑淀粉样蛋白沉积以及潜在的AD血液生物标志物之间存在复杂的关系。此外,APOE ε4的作用尚不清楚,需要更多的研究来进一步阐明。

原文出处

The Association Between Alzheimer's Disease-Related Markers and Physical Activity in Cognitively Normal Older Adults. Front. Aging Neurosci., 28 March 2022 | https://doi.org/10.3389/fnagi.2022.771214

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    2022-05-23 lsndxfj
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    2022-05-22 ms5000000518166734

    学习学习学习学习学习学习学习学习学习学习学习学习学习学习学习学习学习学习学习学习学习学习

    0

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