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JAHA：血清非酯化脂肪酸与冠心病死亡率和非致死性心肌梗死之间的关系

2021-03-10 MedSci原创 MedSci原创

冠心病死亡率非酯化脂肪酸非致死性心肌梗死
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2个NEFAs(二高-γ-亚麻酸和反油酸)分别与CHD死亡率和非致死性MI之间呈正相关，提示其是CHD死亡和非致死性MI风险潜在的易感生物标志物。

一些前瞻性队列研究已经报道血清总非酯化脂肪酸(NEFA)浓度与冠心病(CHD)死亡率和非致死性心肌梗死(MI)发生率之间存在显著相关性。然而，血清NEFAs中单个或亚类(饱和、多不饱和[n-6和n-3]以及反式脂肪酸)是否与CHD死亡率和非致死性MI有关，目前尚未明确。

近日，心血管疾病领域权威杂志JAHA上发表了一篇研究文章，研究人员纳入了心血管健康研究（CHS）中(1996-1997)无MI、心绞痛、血运重建术史或基线时无MI的参与者(N=1681)。研究人员采用气相色谱法对NEFAs进行定量，并通过Cox回归分析评估了5个亚类和单个NEFAs与CHD复合结局(CHD死亡率和非致死性MI)、CHD死亡率和非致死性MI事件之间的相关性。

在11.7年的中位随访中，共发生了266例CHD死亡和271例非致死性MI。在完全调整的模型中，单个NEFA与CHD复合结局之间没有显著的关联。

探索性分析表明月桂酸(12:0)与CHD病死率呈负相关(风险比[HR]为0.76；95%置信区间为0.59-0.98；P=0.0328)，而二高-γ-亚麻酸(20:3n-6)与CHD死亡率呈正相关(HR为1.34；95%置信区间为1.02-1.76；P=0.0351)。反油酸(18:1n‐7t)与非致死性MI呈正相关(HR为1.46；95%CI为1.01-2.12；P=0.0445)。未观察到NEFA亚类和任何结局之间存在显著的相关性。

在CHS参与者中，2个NEFAs(二高-γ-亚麻酸和反油酸)分别与CHD死亡率和非致死性MI之间呈正相关，提示其是CHD死亡和非致死性MI风险潜在的易感生物标志物。

原始出处：

Neil K. Huang.et al.Associations of Serum Nonesterified Fatty Acids With Coronary Heart Disease Mortality and Nonfatal Myocardial Infarction: The CHS (Cardiovascular Health Study) Cohort.J AM HEART ASSOC.2021.https://www.ahajournals.org/doi/10.1161/JAHA.120.019341

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    2021-11-10 taken110

    进原文看看

    0

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    2022-01-07 dinorsor524

    #非致死性#

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    2021-03-24 科研科研科研

    血清非酯化脂肪酸与冠心病死亡率有关

    0

  4. 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    2021-03-11 zhaohui6731

    #AHA#

    0

  5. 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    2021-03-11 andy2092

    #致死性#

    0

  6. 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    2021-03-11 ms4000001991522787

    学习了

    0

  7. 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    2021-03-11 易水河

    学习学习

    0

  8. 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    2021-03-10 胖鑫叫兽

    血脂全系列被掏空

    0

  9. 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    2021-03-10 科研科研科研

    冠心病

    0

  10. 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    2021-03-10 科研科研科研

    冠心病

    0

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CTO病变经皮冠状动脉介入治疗(PCI) 在3年随访期内没有显示出心脑血管事件获益，那么行PCI术的意义在哪里？-JAHA：在10年后

Lancet Public Health：独居或社交少的人群冠心病发作或中风时的非入院死亡率高达近2倍！

独居的你，怕了吗？