GC4419治疗晚期胰腺癌的I/II期临床试验:已取得阳性数据

2020-10-24 Allan MedSci原创

生物制药公司Galera近日宣布,GC4419联合SBRT治疗晚期胰腺癌的I/II期临床试验已取得阳性数据。

选择性超氧化物歧化酶(SOD)模拟物GC4419旨在将超氧化物快速转化为过氧化氢和氧气,从而保护正常组织免受与放射疗法有关的损害。如果不及时治疗,超氧化物的升高会损害非癌性组织并导致使人衰弱的副作用,包括口腔粘膜炎(OM),这可能会限制放射疗法的抗肿瘤功效。基于多种临床前模型的阳性结果,GC4419具有潜在的抗癌协同作用。

生物制药公司Galera近日宣布,GC4419联合SBRT治疗晚期胰腺癌的I/II期临床试验已取得阳性数据。在该研究的意向性治疗队列(n = 19)中,与安慰剂(安慰剂+SBRT)组的40.4周相比,GC4419组(GC4419+SBRT)患者的中位总生存期(OS)尚未达到(HR = 0.3,95%CI 0.09-1.05,p = 0.046),GC4419组还表现出良好的无进展生存期。

Galera总裁兼首席执行官Mel Sorensen表示:“胰腺癌患者的治疗选择有限。通过将我们的研究性歧化酶模拟物与SBRT结合,我们相信我们有机会改善肿瘤反应和生存结果”。

 

原始出处:

https://www.firstwordpharma.com/node/1768065?tsid=4

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J Gastroenterology:基于PCR的血浆无细胞DNA突变分析可用于早期胰腺肿瘤的诊断和监测

胰腺导管腺癌(PDA)是世界上最致命的癌症之一。为了改善PDA的预后,开发一个能够早期检测的新生物标记物在临床上是一个紧迫的需求。在PDA患者中,超过90%的患者发现了KRAS突变。