Am J Clin Nutr:类风湿关节炎的抗炎饮食(ADIRA)对疾病活动的影响

2020-08-01 MedSci原创 MedSci原创

许多类风湿性关节炎(RA)患者报告说,某些食物可以缓解症状。早期的研究表明,食物和食物成分对RA的临床结果有积极的影响,但没有足够的证据提供具体的饮食建议。食物成分可能会相互作用,但缺乏评估联合效应的

许多类风湿性关节炎(RA)患者报告说,某些食物可以缓解症状。早期的研究表明,食物和食物成分对RA的临床结果有积极的影响,但没有足够的证据提供具体的饮食建议。食物成分可能会相互作用,但缺乏评估联合效应的研究。我们旨在研究抗炎饮食是否能降低RA患者的疾病活动。

 

在这项单盲交叉试验中,50名RA患者被随机将50名RA患者分配到干预饮食中,其中包含建议的抗炎食物组合,或与瑞典的一般饮食摄入量相似的对照饮食,持续10周。在4个月的冲洗期后,参与者切换饮食。每周将约等于能源需求量50%的食物运到他们的家中。其余的膳食,鼓励他们食用与每次饮食期间所提供的相同类型的食物。主要结果是28个关节的疾病活动评分-红细胞沉降率(DAS28-ESR)的变化。次要结果是DAS28-ESR(软和肿胀的关节、ESR和一般健康的视觉模拟量表)和DAS28-C-反应蛋白的成分变化。

 

结果,在主要分析中,采用线性混合ANCOVA模型,其中包括47个完成≥1个饮食期的参与者,干预期和对照期之间的DAS28-ESR没有明显差异(P = 0.116)。然而,在未经校正的分析中,完成两个时期的参与者的DAS28-ESR在干预期显著下降,并且在干预后显著低于对照期(n = 44;中位数:3.05;IQR:2.41,3.79;与中位数相比:3.27;IQR:2.69,4.28;P = 0.04,Wilcoxon's Signed Rank检验)。各组分无显著差异。

 

总之,该试验表明,拟议的抗炎饮食对RA患者的疾病活动有积极作用。需要更多的研究来确定这种饮食是否能引起临床相关的改善。

 

原始出处:

 

Anna K E VadellLinnea Bärebring, et al., Anti-inflammatory Diet In Rheumatoid Arthritis (ADIRA)-a randomized, controlled crossover trial indicating effects on disease activity. Am J Clin Nutr. 2020 Jun 1;111(6):1203-1213. doi: 10.1093/ajcn/nqaa019.

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    2020-08-12 两百斤的胖子

    有意思,需要更多样本量和基础研究

    0

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