NEJM:BNT162b2 mRNA疫苗在以色列大规模接种后的有效性评估

2021-02-25 MedSci原创 MedSci原创

通过以色列全国的大规模疫苗接种,BNT162b2 mRNA疫苗的有效性得到了充分验证

随着2019年冠状病毒病(Covid-19)疫苗接种在世界范围内开展,疫苗的有效性需要在非控制的环境下对不同人群进行验证。近日研究人员考察了BNT162b2 mRNA疫苗在以色列大规模接种后的有效性。
 
参与者为2020年12月20日至2021年2月1日间接种BNT162b2 mRNA疫苗人群,依据人口学和临床特征匹配未接种人群。研究的主要终点为感染严重急性呼吸综合征冠状病毒2(SARS-cov-2),症状性Covid-19,Covid-19相关住院,严重疾病和死亡。
 
研究期间,总计596618 人接种疫苗,在第一次接种后14-20天,以及第二次接种后至少7天后,接种疫苗vs未接种疫苗人群的终点事件数据如下:SARS-COV-2感染,46% vs 92%;症状性Covid-19,57% vs 94%;Covid-19住院,74% vs 87%;重症Covid-19,62% vs 92%。研究发现,在第一次接种后14-20天,疫苗保护接种人群免于新冠肺炎死亡的有效性为72%。在不同年龄人群中,疫苗预防感染和症状性covid-19的有效性一致,但在具有多种共病人群中,潜在的有效性略低。
 
通过以色列全国的大规模疫苗接种,BNT162b2 mRNA疫苗的有效性得到了充分验证
 
原始出处:
 
Noa Dagan et al. BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting. N Engl J Med, February 24 2021.

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    2021-11-05 ylz8403
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    2021-02-26 ms7000001204488220

    学习

    0

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    2021-02-25 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2043438, encodeId=9c8a2043438ea, content=<a href='/topic/show?id=13304400293' target=_blank style='color:#2F92EE;'>#大规模#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44002, encryptionId=13304400293, topicName=大规模)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3fce464, createdName=ylz8403, createdTime=Fri Nov 05 16:16:58 CST 2021, time=2021-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1947373, encodeId=f0fc194e3730b, content=<a href='/topic/show?id=88d81556543' target=_blank style='color:#2F92EE;'>#RNA疫苗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15565, encryptionId=88d81556543, topicName=RNA疫苗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ce072500140, createdName=12498b3em08(暂无昵称), createdTime=Fri Mar 19 19:16:58 CST 2021, time=2021-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=927260, encodeId=9d2392e260d7, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210224/ce0d4123440c4a7dbcb2e72458d6c283/7cc60f034a584c3dabbaa659278e106d.jpg, createdBy=82e45441201, createdName=ms7000001204488220, createdTime=Fri Feb 26 00:07:18 CST 2021, time=2021-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035585, encodeId=73901035585d3, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Thu Feb 25 22:16:58 CST 2021, time=2021-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=927216, encodeId=efc892e21616, content=<a href='/topic/show?id=4dbd580630b' target=_blank style='color:#2F92EE;'>#新冠疫苗#</a>现在看来两针间隔2-3个月,效果可能最好!强生的<a href='/topic/show?id=62afe048720' target=_blank style='color:#2F92EE;'>#疫苗#</a>虽然只要一针,事实上,也应该接种2针。我们国内的<a href='/topic/show?id=de9d66915e9' target=_blank style='color:#2F92EE;'>#灭活疫苗#</a>,现在间隔14-21天,但是最佳间隔时间,目前还缺乏数据支持,希望厂家能开展相关研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=429, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58063, encryptionId=4dbd580630b, topicName=新冠疫苗), TopicDto(id=70487, encryptionId=62afe048720, topicName=疫苗), TopicDto(id=66915, encryptionId=de9d66915e9, topicName=灭活疫苗)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=健康达人, createdTime=Thu Feb 25 20:47:49 CST 2021, time=2021-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=927196, encodeId=383892e196da, content=谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b152414560, createdName=12382c39m81暂无昵称, createdTime=Thu Feb 25 19:23:26 CST 2021, time=2021-02-25, status=1, ipAttribution=)]
    2021-02-25 健康达人

    #新冠疫苗#现在看来两针间隔2-3个月,效果可能最好!强生的#疫苗#虽然只要一针,事实上,也应该接种2针。我们国内的#灭活疫苗#,现在间隔14-21天,但是最佳间隔时间,目前还缺乏数据支持,希望厂家能开展相关研究

    0

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    2021-02-25 12382c39m81暂无昵称

    谢谢

    0

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