Allergy:鼻内皮质激素治疗对2型先天淋巴细胞的影响研究

2021-04-21 AlexYang MedSci原创

过敏性鼻炎具有鼻出血、鼻塞、打喷嚏和鼻腔瘙痒的特征。鼻腔过敏原挑战(NAC)后,鼻黏膜中的2型先天淋巴细胞(ILC2s)、CD4+T细胞和嗜酸性粒细胞均显著增加。但鼻腔内皮质激素(INCS)对ILC2

过敏性鼻炎具有鼻出血、鼻塞、打喷嚏和鼻腔瘙痒的特征。鼻腔过敏原挑战(NAC)后,鼻黏膜中的2型先天淋巴细胞(ILC2s)、CD4+T细胞和嗜酸性粒细胞均显著增加。但鼻腔内皮质激素(INCS)对ILC2s的影响还有待研究

最近,有研究人员将患有过敏性鼻炎和轻度哮喘的受试者(n=10)纳入了单盲、安慰剂对照的序贯治疗研究中,每日两次鼻内曲安奈德(220?g)或安慰剂治疗14天,间隔7天的冲洗期。治疗后对受试者进行NAC和上气道功能评估。鼻黏膜和血液中的细胞在NAC后24小时取样,并进行流式细胞计数来检测ILC2s、CD4+T和嗜酸性粒细胞祖细胞(EoPs)水平。

研究结果表明,INCSs治疗显著减少了ILC2s,IL-5+ /IL-13+ ILC2s,HLA-DR+ ILC2s和CD4+ T细胞在鼻粘膜中的水平(NAC 24小时后)。INCS与安慰剂治疗后24h相比,鼻粘膜中的EoPin显著增加,而成熟的嗜酸性粒细胞显著减少。INCS治疗后,IL-2、IL-4、IL-5和IL-13在NAC后24h明显减少,同时伴有上气道功能的明显改善。

安慰剂组和INCS组NAC前后的鼻症状和嗜酸性粒细胞水平

最后,研究人员指出,INCS预处理可减弱过敏原引起的轻度哮喘过敏性鼻炎患者的鼻粘膜ILC2s、CD4+T细胞和末端分化EoPsin的增加,且对全身影响不大。ILC2s减弱HLA-DR的表达可能是类固醇调节上呼吸道适应性免疫反应的另一种机制

原始出处:

Yanqing Xie , Xiaotian Ju , Suzanne Beaudin et al. Effect of Intranasal corticosteroid treatment on allergen-induced changes in group 2 innate lymphoid cells in allergic rhinitics with mild asthma. Allergy. Mar 2021

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    2021-04-23 膀胱癌
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