J Rheumatol:光谱传输技术对类风湿性关节炎的诊断价值

2020-04-26 xiangting MedSci原创

RA患者的OST值高于对照组。此外,OST与临床、超声和实验室疾病活动性标志物相关。

这项研究旨在探讨光谱传输(OST)在检测类风湿性关节炎(RA)患者关节炎症中的价值,并评估OST是否与某些患者特征相关。

对168例RA患者和114例对照者的掌指、近端指骨内和腕关节进行OST检测。对两组间的OST差异进行了统计分析,然后控制可能的混杂因素的影响。通过受试者工作特征检验了OST的诊断性能。此外,通过Spearmann检验和广义线性统计调整模型评估了OST与临床和血清活动性指标(患者组)、关节超声(US)(患者亚组)以及各种身体测量指标和流行病学指标(患者和对照组)之间的关联。

即使校正了混杂因素后,RA组的OST仍明显高于对照组[1.89;95%CI(0.709–3.070),Padj=0.002)]。以US为参考,全部1,251个关节的曲线下面积(AUC)均为0.67(95%CI=0.631-0.709)。在患者组中,相关性和调整分析显示OST与各种疾病活动性标志物[DAS28(rho=0.313)、肿胀关节计数(rho=0.361)、CRP(rho=0.389);全部Padj=0.001]、年龄(rho=0.276,p<0.001)和骨关节炎相关(p=0.022)。而且,OST与功率多普勒(rho=0.442;p=0.001)和灰度US评分(rho=0.591;p<0.001)相关。在两组中,男性的OST值均明显高于女性,并且OST与BMI呈中等偏弱相关(rho患者=0.316,rho对照=0.24)(全部;p<0.001)。

RA患者的OST值高于对照组。此外,OST与临床、超声和实验室疾病活动性标志物相关。

原始出处:

Konstantinos Triantafyllias. Diagnostic value of optical spectral transmission in rheumatoid arthritis: associations with clinical characteristics and comparison with joint ultrasonography. J Rheumatol. 01 April 2020.

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    2020-04-28 lmm397
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