JCEM:1型糖尿病和COVID-19患者的年龄和住院风险

2021-09-29 MedSci原创 MedSci原创

年龄40岁以上是T1D和COVID-19患者的危险因素,儿童和年轻人的病情较轻,预后较好。这表明需要对受T1D影响的个体进行针对年龄的治疗、免疫和临床管理。

COVID-19发病率和死亡率在1型糖尿病(T1D)患者中有所增加,但很少有数据关注基于年龄的患者结局。

近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,研究人员旨在量化T1D患者不同年龄的COVID-19相关住院风险和不良结局。

研究人员对于来自美国56个临床站点的T1D患者和经实验室确诊的COVID-19患者开展了这项观察性、多站点、横断面研究,数据收集时间为2020年4月至2021年3月。研究人员评估了各年龄组(0-18、19-40和>40岁)中患者因素和结局的分布,并使用描述性统计方法描述了研究人群,并使用多元Logistic回归模型分析年龄、不良结局和住院之间的关系。该研究的主要观察指标为COVID-19住院治疗。

该研究共分析了767名患者。54%(n=415)患者的年龄为0-18岁,32%(n=247)患者的年龄为19-40岁,14%(n=105)患者的年龄>40岁。170名患者住院,5名患者死亡。与0-18岁年龄组患者相比,在调整性别、A1c、种族、保险类型和合并症后,40岁以上的患者住院的调整比值比为4.2(95%置信区间为2.28-7.83)。

由此可见,年龄40岁以上是T1D和COVID-19患者的危险因素,儿童和年轻人的病情较轻,预后较好。这表明需要对受T1D影响的个体进行针对年龄的治疗、免疫和临床管理

原始出处:

Carla Demeterco-Berggren.et al.Age and Hospitalization Risk in People with Type 1 Diabetes and COVID-19: Data from the T1D Exchange Surveillance Study.JCEM.2021.https://doi.org/10.1210/clinem/dgab668

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    2022-02-14 仁者大医
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    2021-12-23 achengzhao
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