Diabetes Care:糖尿病患者血糖控制、糖尿病并发症与痴呆风险

2021-06-13 网络 网络

2型糖尿病患者较高或不稳定的HbA1c水平和伴有糖尿病并发症与痴呆风险增加相关。有效的血糖控制可能对维持老年糖尿病患者认知健康具有重要意义。

2型糖尿病是痴呆已知的危险因素。然而,血糖控制和糖尿病并发症在痴呆发展中的作用尚未证实。

近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,这项大规模队列研究旨在探究2型糖尿病患者纵向糖化血红蛋白水平和糖尿病并发症与痴呆发生率之间的关系。

研究人员分析了1987年至2018年期间英国临床实践研究数据链中年龄≥50岁的符合条件的糖尿病患者数据,并采用时变Cox回归估计痴呆风险的校正风险比(HRs)和95%CI。

在457902名糖尿病患者中,在中位6年的随访期间,研究人员发现了28627例(6.3%)痴呆病例。与无低血糖事件或微血管并发症的患者相比,伴有低血糖事件或微血管并发症的患者患痴呆的风险更高(HR分别为1.30 [95%CI为1.22-1.39]和1.10[1.06-1.14])。在372287例伴有HbA1c记录的糖尿病患者中,HbA1c水平与痴呆风险增加相关(HbA1c升高1%的风险比为1.08 [95%CI为1.07-1.09])。同样,在最初3年的随访期间中,HbA1c的变异系数越高,随后发生痴呆的风险就越高(每增加1个SD, HR为1.03 [95%CI为1.01-1.04])。

由此可见,2型糖尿病患者较高或不稳定的HbA1c水平和伴有糖尿病并发症与痴呆风险增加相关。有效的血糖控制可能对维持老年糖尿病患者认知健康具有重要意义
 
原始出处:
 
Bang Zheng,et al.Glycemic Control, Diabetic Complications, and Risk of Dementia in Patients With Diabetes: Results From a Large U.K. Cohort Study.Diabetes care.2021.https://doi.org/10.2337/dc20-2850

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    2022-05-29 丁鹏鹏
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    2021-06-27 face

    血糖与痴呆

    0

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    2021-06-14 ms1129413825580304

    学习了

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