JAMA Pediatrics:早产儿的母乳喂养可能增加巨细胞病毒感染风险

2014-09-25 何Jason 医学专业新闻

据在线发表于JAMA Pediatrics的一项研究显示,如果极低出生体重儿接受母乳喂养,则感染巨细胞病毒(CMV)的风险显著增加,甚至高于输血。在这项纳入500名极低出生体重儿的研究中,所有参与者的出生体重均低于3.3磅,多数母体有CMV感染病史。随后研究人员对比了母乳喂养和输血的CMV感染风险差异。结果显示,接受母乳喂养的极低出生体重儿中有29人确诊CMV感染,其中27人确定于母乳有关;输血组

据在线发表于JAMA Pediatrics的一项研究显示,如果极低出生体重儿接受母乳喂养,则感染巨细胞病毒(CMV)的风险显著增加,甚至高于输血。

在这项纳入500名极低出生体重儿的研究中,所有参与者的出生体重均低于3.3磅,多数母体有CMV感染病史。随后研究人员对比了母乳喂养和输血的CMV感染风险差异。

结果显示,接受母乳喂养的极低出生体重儿中有29人确诊CMV感染,其中27人确定于母乳有关;输血组感染CMV的人数为零。

本研究的通讯作者,来自美国亚特兰大埃默里大学医学院的病理学和儿科学教授Dr. Cassandra Josephson说:“此前我们并未预计到母乳中竟存在如此多的巨细胞病毒。”

他表示,由于极低出生体重儿所输注的血液均经过严格检测,包括筛查CMV和滤过白细胞等措施,有助降低CMV的感染风险。

而这些产妇中,约三分之一为CMV阳性。CMV是一种疱疹病毒,并不引起临床症状,但对于存在免疫功能受损的人群,CMV可引起严重疾病。大部分感染者可自愈,但对于极低出生体重儿,CMV感染常引起严重后果。

作者建议,有早产风险的孕妇都有必要进行CMV筛查。考虑到母乳喂养的巨大获益,目前并不建议极低出生体重儿停止接受母乳喂养,而且还存在其它的CMV感染途径。

奥地利儿科学会建议,对于所有接受母乳喂养的极低出生体重儿,喂养的母乳都需要经过巴氏消毒,直至胎龄达到34周。

原始出处:

Josephson CD1, Caliendo AM2, Easley KA3, Knezevic A3, Shenvi N3, Hinkes MT4, Patel RM5, Hillyer CD6, Roback JD7.Blood Transfusion and Breast Milk Transmission of Cytomegalovirus in Very Low-Birth-Weight Infants : A Prospective Cohort Study.JAMA Pediatr. 2014 Sep 22. doi: 10.1001/jamapediatrics.2014.1360. [Epub ahead of print]

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    2014-10-16 hbwxf
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    2015-01-08 feather89
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    2014-09-27 villahu
  6. [GetPortalCommentsPageByObjectIdResponse(id=1664943, encodeId=df89166494391, content=<a href='/topic/show?id=c8664008e1a' target=_blank style='color:#2F92EE;'>#喂养#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40087, encryptionId=c8664008e1a, topicName=喂养)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0ed425881542, createdName=ms1948154235210413, createdTime=Thu Jul 30 03:22:00 CST 2015, time=2015-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1958391, encodeId=a89c19583912d, content=<a href='/topic/show?id=766713993a1' target=_blank style='color:#2F92EE;'>#Pediatric#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13993, encryptionId=766713993a1, topicName=Pediatric)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Thu Oct 16 11:22:00 CST 2014, time=2014-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1636944, encodeId=7c6e1636944c5, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Wed Jun 10 05:22:00 CST 2015, time=2015-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1725661, encodeId=ad691e25661b1, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu Jan 08 19:22:00 CST 2015, time=2015-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1299476, encodeId=bdad12994e667, content=<a href='/topic/show?id=7a056349485' target=_blank style='color:#2F92EE;'>#母乳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63494, encryptionId=7a056349485, topicName=母乳)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf1b289, createdName=villahu, createdTime=Sat Sep 27 08:22:00 CST 2014, time=2014-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1502170, encodeId=b36d15021e060, content=<a href='/topic/show?id=021d4821096' target=_blank style='color:#2F92EE;'>#巨细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48210, encryptionId=021d4821096, topicName=巨细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11759518880, createdName=wwzzly, createdTime=Sat Sep 27 08:22:00 CST 2014, time=2014-09-27, status=1, ipAttribution=)]
    2014-09-27 wwzzly

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