Hypertension:血压变异性增大提示阿尔茨海默病认知恶化

2019-09-24 国际循环编辑部 国际循环

血压变异性(BPV)比单纯的血压(BP)更有卒中预测价值。近期发表于Hypertension杂志的一项研究对BPV的具体预测价值进行了评估。研究人员以一项欧洲多中心、双盲、安慰剂对照轻中度阿尔茨海默病治疗III期试验的数据为基础,评估BPV是否能预测阿尔茨海默病所致认知功能下降。研究纳入诊室血压测量3次以上可用于确定BPV轻度至中度阿尔茨海默新疆人民核心技术美患者,并使用亚组样本中的家庭血压测量值

血压变异性(BPV)比单纯的血压(BP)更有卒中预测价值。近期发表于Hypertension杂志的一项研究对BPV的具体预测价值进行了评估。研究人员以一项欧洲多中心、双盲、安慰剂对照轻中度阿尔茨海默病治疗III期试验的数据为基础,评估BPV是否能预测阿尔茨海默病所致认知功能下降。研究纳入诊室血压测量3次以上可用于确定BPV轻度至中度阿尔茨海默新疆人民核心技术美患者,并使用亚组样本中的家庭血压测量值作为日常血压,用与平均值无关的变异来计算BPV,以1年和1.5年后阿尔茨海默病认知评估量表和痴呆残疾评估值的变化作为终点。研究最终纳入460例患者,平均年龄72.1岁(SD=8.1),平均血压134.0/75.1 mm Hg。1年后的阿尔茨海默病认知量表的评估结果显示,BPV处于最高四分位的患者比最低四分位的患者恶化更多[收缩压:β,2.24(95%CI:0.11~4.38),P=0.040;舒张压:β,2.54(95%CI:0.33~4.75),P=0.024]。1.5年后的研究结果显示了相同的联系[收缩压:β,2.86(95%CI:0.35~5.36),P=0.026;舒张压:β,3.30

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    2019-11-10 zhouqu_8
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  8. 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    2019-09-25 心介

    #血压变异性#相信未来5年是热点,不仅关心血压高与低,还要关注血压变异性才可以

    0

  9. 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    2019-09-25 飛歌

    学习了,很有用,不错

    0

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