Diabetes Obes Metab：艾格列净对尿糖和尿钠生物标志物的不同作用

2022-05-17 从医路漫漫 MedSci原创

SGLT2抑制剂的利钠作用与全身容量相关变化密切相关，这可能是血压(BP)和心力衰竭风险的一个重要决定因素。

背景：阻断肾脏近曲小管中的钠-葡萄糖协同转运蛋白-2 (SGLT2)具有两种同时发生的直接效应:抑制肾脏从尿液滤液中重吸收葡萄糖，从而导致糖尿；抑制钠重吸收，从而导致尿钠排泄。SGLT2抑制剂的利钠作用与全身容量相关变化密切相关，这可能是血压(BP)和心力衰竭风险的一个重要决定因素。这一点，结合对葡萄糖尿相关作用随肾功能下降而减弱的观察，尽管有持续的临床益处，但支持SGLT2抑制剂的心肾益处在很大程度上独立于葡萄糖降低的概念。鉴于在估计的肾小球滤过率(eGFR)下降和心肾保护的意义上，减弱的血糖降低和保留的尿钠排泄之间的不一致，在大型临床试验中阐明SGLT2抑制剂对可能介导心力衰竭和肾脏临床保护的因素的影响是重要的。我们试图通过与其他与尿糖或尿钠排泄相关的生物标志物相比较，评估厄替格列吡嗪对血糖疗效的相对影响。

目的:VERTIS CV (NCT01986881)的这一预先指定的探索性分析旨在根据肾功能风险类别，评估钠-葡萄糖协同转运蛋白-2 (SGLT2)抑制剂艾格列净对糖尿相关(糖化血红蛋白[HbA1c]、尿酸、体重)和尿钠排泄相关(血压、血红蛋白、红细胞压积、血清白蛋白)生物标志物的影响。

材料和方法:患有2型糖尿病和动脉粥样硬化性心血管疾病的患者被随机分为安慰剂组、艾格列净5 mg组或艾格列净15 mg组(1:1:1)。分析比较了安慰剂组(n = 2747)和艾格列净组(合并；n = 5499)根据基线估计肾小球滤过率(eGFR)亚组和肾脏疾病:改善慢性肾脏疾病(KDIGO CKD)风险类别的葡萄糖尿和尿钠排泄相关生物标志物。

结果:患者按KDIGO CKD低危(-49%)、中危(-32%)和高危/极高危(-19%)进行分类，EGFR组1(25%)、2(53%)和3(19%)。在第18周，与低风险组(-0.54[-0.60，-0.49])和中风险组(-0.47[-0.54，-0.40])相比，高风险/极高风险类别的HbA1c与基线(95%可信区间)相比，安慰剂减去最小二乘平均值(LSM)变化较小(-0.34[-0.43，-0.25])。这一模式在整个研究过程中一直保持不变(P交互作用=0.0001)。基于基线EGFR G分期的相似模式也被观察到。在第6周和第18周，与基线相比，减去安慰剂后尿酸的LSM变化在高风险/极高风险类别中最低，但在156周后这种模式不再保持(P交互作用=0.15)。在不同的KDIGO CKD类别中，艾格列净对体重和利钠相关生物标记物的影响没有差异。

图 1在基线肾脏疾病改善慢性肾脏疾病(KDIGO CKD)风险类别中与血糖尿相关的生物标记物中，艾格列净与安慰剂的安慰剂吸收最小二乘平均值(LSM)差异估计。*中风险组和低风险组之间的95%可信区间(CI)不重叠。低风险组和高/极高风险组之间的†95%CI不重叠。糖化血红蛋白

图 2安慰剂减去最小二乘平均数(LSM)在与肾脏疾病钠尿相关的生物标志物中，艾格列净与安慰剂的差异改善慢性肾脏疾病(KDIGO CKD)风险类别的全球结局。BP，血压；CI，可信区间

结论:在VERTIS CV中，艾格列净与尿糖和尿钠排泄相关生物标志物的生理学有利变化相关。在慢性肾病(CKD)风险较高的患者中，艾格列净的血糖控制效果减弱。对其他生物标志物的影响是一致的，与CKD风险阶段无关。

原文出处：Cherney DZI, Cosentino F, Pratley RE,et al.The differential effects of ertugliflozin on glucosuria and natriuresis biomarkers: Prespecified analyses from VERTIS CV.Diabetes Obes Metab 2022 06;24(6)

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2022-09-19 ms9608593228839890

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createdTime=Wed May 18 08:07:20 CST 2022, time=2022-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1220594, encodeId=f368122059439, content=列净类药物新用途, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0825417521, createdName=ms6000000960504356, createdTime=Wed May 18 08:06:38 CST 2022, time=2022-05-18, status=1, ipAttribution=)]
2022-06-22 liubm563

#尿糖#

32 0
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createdBy=987022654425, createdName=ms9608593228839890, createdTime=Mon Sep 19 03:02:32 CST 2022, time=2022-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1645930, encodeId=25f416459301d, content=<a href='/topic/show?id=64644e490b0' target=_blank style='color:#2F92EE;'>#尿糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47490, encryptionId=64644e490b0, topicName=尿糖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bce523261420, createdName=liubm563, createdTime=Wed Jun 22 20:02:32 CST 2022, time=2022-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761924, encodeId=c3b71e61924d8, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Thu Apr 06 06:02:32 CST 2023, time=2023-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1841873, encodeId=81ff18418e3f5, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Sat Mar 04 05:02:32 CST 2023, time=2023-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1897016, encodeId=f424189e01664, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Wed Oct 12 00:02:32 CST 2022, time=2022-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1888436, encodeId=f788188843650, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Thu Dec 15 16:02:32 CST 2022, time=2022-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1220677, encodeId=cd1712206e7c6, content=学习了，知道了列净类的药理作用 , beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3e76499938, createdName=ms6000001791212108, createdTime=Wed May 18 15:18:48 CST 2022, time=2022-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1220595, encodeId=eb3a12205956e, content=<a href='/topic/show?id=23e3454e353' target=_blank style='color:#2F92EE;'>#学习#</a><a href='/topic/show?id=4f77e665253' target=_blank style='color:#2F92EE;'>#糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45473, encryptionId=23e3454e353, topicName=学习), TopicDto(id=76652, encryptionId=4f77e665253, topicName=糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0825417521, createdName=ms6000000960504356, createdTime=Wed May 18 08:07:20 CST 2022, time=2022-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1220594, encodeId=f368122059439, content=列净类药物新用途, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0825417521, createdName=ms6000000960504356, createdTime=Wed May 18 08:06:38 CST 2022, time=2022-05-18, status=1, ipAttribution=)]
2023-04-06 docwu2019

#BET#

35 0
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createdBy=987022654425, createdName=ms9608593228839890, createdTime=Mon Sep 19 03:02:32 CST 2022, time=2022-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1645930, encodeId=25f416459301d, content=<a href='/topic/show?id=64644e490b0' target=_blank style='color:#2F92EE;'>#尿糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47490, encryptionId=64644e490b0, topicName=尿糖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bce523261420, createdName=liubm563, createdTime=Wed Jun 22 20:02:32 CST 2022, time=2022-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761924, encodeId=c3b71e61924d8, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Thu Apr 06 06:02:32 CST 2023, time=2023-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1841873, encodeId=81ff18418e3f5, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Sat Mar 04 05:02:32 CST 2023, time=2023-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1897016, encodeId=f424189e01664, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Wed Oct 12 00:02:32 CST 2022, time=2022-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1888436, encodeId=f788188843650, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Thu Dec 15 16:02:32 CST 2022, time=2022-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1220677, encodeId=cd1712206e7c6, content=学习了，知道了列净类的药理作用 , beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3e76499938, createdName=ms6000001791212108, createdTime=Wed May 18 15:18:48 CST 2022, time=2022-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1220595, encodeId=eb3a12205956e, content=<a href='/topic/show?id=23e3454e353' target=_blank style='color:#2F92EE;'>#学习#</a><a href='/topic/show?id=4f77e665253' target=_blank style='color:#2F92EE;'>#糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45473, encryptionId=23e3454e353, topicName=学习), TopicDto(id=76652, encryptionId=4f77e665253, topicName=糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0825417521, createdName=ms6000000960504356, createdTime=Wed May 18 08:07:20 CST 2022, time=2022-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1220594, encodeId=f368122059439, content=列净类药物新用途, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0825417521, createdName=ms6000000960504356, createdTime=Wed May 18 08:06:38 CST 2022, time=2022-05-18, status=1, ipAttribution=)]
2023-03-04 hukaixun

#标志物#

36 0
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createdBy=987022654425, createdName=ms9608593228839890, createdTime=Mon Sep 19 03:02:32 CST 2022, time=2022-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1645930, encodeId=25f416459301d, content=<a href='/topic/show?id=64644e490b0' target=_blank style='color:#2F92EE;'>#尿糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47490, encryptionId=64644e490b0, topicName=尿糖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bce523261420, createdName=liubm563, createdTime=Wed Jun 22 20:02:32 CST 2022, time=2022-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761924, encodeId=c3b71e61924d8, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Thu Apr 06 06:02:32 CST 2023, time=2023-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1841873, encodeId=81ff18418e3f5, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Sat Mar 04 05:02:32 CST 2023, time=2023-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1897016, encodeId=f424189e01664, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Wed Oct 12 00:02:32 CST 2022, time=2022-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1888436, encodeId=f788188843650, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Thu Dec 15 16:02:32 CST 2022, time=2022-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1220677, encodeId=cd1712206e7c6, content=学习了，知道了列净类的药理作用 , beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3e76499938, createdName=ms6000001791212108, createdTime=Wed May 18 15:18:48 CST 2022, time=2022-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1220595, encodeId=eb3a12205956e, content=<a href='/topic/show?id=23e3454e353' target=_blank style='color:#2F92EE;'>#学习#</a><a href='/topic/show?id=4f77e665253' target=_blank style='color:#2F92EE;'>#糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45473, encryptionId=23e3454e353, topicName=学习), TopicDto(id=76652, encryptionId=4f77e665253, topicName=糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0825417521, createdName=ms6000000960504356, createdTime=Wed May 18 08:07:20 CST 2022, time=2022-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1220594, encodeId=f368122059439, content=列净类药物新用途, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0825417521, createdName=ms6000000960504356, createdTime=Wed May 18 08:06:38 CST 2022, time=2022-05-18, status=1, ipAttribution=)]
2022-10-12 一闲

#MET#

20 0
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topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Thu Apr 06 06:02:32 CST 2023, time=2023-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1841873, encodeId=81ff18418e3f5, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Sat Mar 04 05:02:32 CST 2023, time=2023-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1897016, encodeId=f424189e01664, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Wed Oct 12 00:02:32 CST 2022, time=2022-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1888436, encodeId=f788188843650, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Thu Dec 15 16:02:32 CST 2022, time=2022-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1220677, encodeId=cd1712206e7c6, content=学习了，知道了列净类的药理作用 , beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3e76499938, createdName=ms6000001791212108, createdTime=Wed May 18 15:18:48 CST 2022, time=2022-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1220595, encodeId=eb3a12205956e, content=<a href='/topic/show?id=23e3454e353' target=_blank style='color:#2F92EE;'>#学习#</a><a href='/topic/show?id=4f77e665253' target=_blank style='color:#2F92EE;'>#糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45473, encryptionId=23e3454e353, topicName=学习), TopicDto(id=76652, encryptionId=4f77e665253, topicName=糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0825417521, createdName=ms6000000960504356, createdTime=Wed May 18 08:07:20 CST 2022, time=2022-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1220594, encodeId=f368122059439, content=列净类药物新用途, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0825417521, createdName=ms6000000960504356, createdTime=Wed May 18 08:06:38 CST 2022, time=2022-05-18, status=1, ipAttribution=)]
2022-12-15 guojianrong

#Meta#

20 0
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createdBy=987022654425, createdName=ms9608593228839890, createdTime=Mon Sep 19 03:02:32 CST 2022, time=2022-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1645930, encodeId=25f416459301d, content=<a href='/topic/show?id=64644e490b0' target=_blank style='color:#2F92EE;'>#尿糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47490, encryptionId=64644e490b0, topicName=尿糖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bce523261420, createdName=liubm563, createdTime=Wed Jun 22 20:02:32 CST 2022, time=2022-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761924, encodeId=c3b71e61924d8, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Thu Apr 06 06:02:32 CST 2023, time=2023-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1841873, encodeId=81ff18418e3f5, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Sat Mar 04 05:02:32 CST 2023, time=2023-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1897016, encodeId=f424189e01664, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Wed Oct 12 00:02:32 CST 2022, time=2022-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1888436, encodeId=f788188843650, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Thu Dec 15 16:02:32 CST 2022, time=2022-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1220677, encodeId=cd1712206e7c6, content=学习了，知道了列净类的药理作用 , beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3e76499938, createdName=ms6000001791212108, createdTime=Wed May 18 15:18:48 CST 2022, time=2022-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1220595, encodeId=eb3a12205956e, content=<a href='/topic/show?id=23e3454e353' target=_blank style='color:#2F92EE;'>#学习#</a><a href='/topic/show?id=4f77e665253' target=_blank style='color:#2F92EE;'>#糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45473, encryptionId=23e3454e353, topicName=学习), TopicDto(id=76652, encryptionId=4f77e665253, topicName=糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0825417521, createdName=ms6000000960504356, createdTime=Wed May 18 08:07:20 CST 2022, time=2022-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1220594, encodeId=f368122059439, content=列净类药物新用途, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0825417521, createdName=ms6000000960504356, createdTime=Wed May 18 08:06:38 CST 2022, time=2022-05-18, status=1, ipAttribution=)]
2022-05-18 ms6000001791212108

学习了，知道了列净类的药理作用

41 0
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createdBy=987022654425, createdName=ms9608593228839890, createdTime=Mon Sep 19 03:02:32 CST 2022, time=2022-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1645930, encodeId=25f416459301d, content=<a href='/topic/show?id=64644e490b0' target=_blank style='color:#2F92EE;'>#尿糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47490, encryptionId=64644e490b0, topicName=尿糖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bce523261420, createdName=liubm563, createdTime=Wed Jun 22 20:02:32 CST 2022, time=2022-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761924, encodeId=c3b71e61924d8, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Thu Apr 06 06:02:32 CST 2023, time=2023-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1841873, encodeId=81ff18418e3f5, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Sat Mar 04 05:02:32 CST 2023, time=2023-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1897016, encodeId=f424189e01664, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Wed Oct 12 00:02:32 CST 2022, time=2022-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1888436, encodeId=f788188843650, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Thu Dec 15 16:02:32 CST 2022, time=2022-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1220677, encodeId=cd1712206e7c6, 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2022-05-18 ms6000000960504356

#学习##糖尿病#

96 0
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createdBy=987022654425, createdName=ms9608593228839890, createdTime=Mon Sep 19 03:02:32 CST 2022, time=2022-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1645930, encodeId=25f416459301d, content=<a href='/topic/show?id=64644e490b0' target=_blank style='color:#2F92EE;'>#尿糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47490, encryptionId=64644e490b0, topicName=尿糖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bce523261420, createdName=liubm563, createdTime=Wed Jun 22 20:02:32 CST 2022, time=2022-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761924, encodeId=c3b71e61924d8, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Thu Apr 06 06:02:32 CST 2023, time=2023-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1841873, encodeId=81ff18418e3f5, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Sat Mar 04 05:02:32 CST 2023, time=2023-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1897016, encodeId=f424189e01664, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, 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content=学习了，知道了列净类的药理作用 , beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3e76499938, createdName=ms6000001791212108, createdTime=Wed May 18 15:18:48 CST 2022, time=2022-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1220595, encodeId=eb3a12205956e, content=<a href='/topic/show?id=23e3454e353' target=_blank style='color:#2F92EE;'>#学习#</a><a href='/topic/show?id=4f77e665253' target=_blank style='color:#2F92EE;'>#糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45473, encryptionId=23e3454e353, topicName=学习), TopicDto(id=76652, encryptionId=4f77e665253, topicName=糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0825417521, createdName=ms6000000960504356, createdTime=Wed May 18 08:07:20 CST 2022, time=2022-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1220594, encodeId=f368122059439, content=列净类药物新用途, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0825417521, createdName=ms6000000960504356, createdTime=Wed May 18 08:06:38 CST 2022, time=2022-05-18, status=1, ipAttribution=)]
2022-05-18 ms6000000960504356

列净类药物新用途

41 0

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