ARD：靶向滑膜成纤维细胞中的 IL-6-Yap-Snail 信号轴可改善炎症性关节炎

2022-01-19 MedSci原创 MedSci原创

该研究旨在了解转录辅因子Yes相关蛋白(Yap)在类风湿关节炎(RA)的滑膜成纤维细胞(SF) 转化成具有侵袭性并导致关节破坏的分子途径中的作用。

目的：该研究旨在了解转录辅因子Yes相关蛋白(Yap)在类风湿关节炎(RA)的滑膜成纤维细胞(SF) 致病性转化成具有侵袭性并导致关节破坏的分子途径中的作用。

方法：通过免疫染色和qRT-PCR分析来自RA患者和抗原诱导性关节炎(AIA)小鼠的滑膜。使用Pdgfrα-CreER和Gdf5-Cre小鼠靶向SF，与用于细胞追踪的荧光报告基因和用于条件性Yap消融的Yap-flox小鼠交叉。通过流式细胞术分析成纤维细胞表型，通过组织学评估关节炎严重程度。使用Yap-Tead报告细胞检测Yap激活和通过邻近连接法检测Yap-Snail相互作用。使用基质胶涂层的transwells分析SF侵袭性。

结果：Yap、其结合伴侣Snail和下游靶结缔组织生长因子在增生的人类RA和小鼠 AIA滑膜中上调，在SF中检测到Yap，但在巨噬细胞中未检测到。谱系追踪显示在AIA 期间表达Pdgfrα的SF多克隆扩增，其中Gdf5谱系SF亚群的主要扩增从胚胎关节间带下降。Gdf5谱系SF显示Yap表达增加，并呈现出侵蚀性表型（podoplanin+Thy-1细胞表面抗原-），侵入软骨和骨骼。Gdf5谱系细胞中条件性消融Yap或表达Pdgfrα的成纤维细胞可改善AIA。白细胞介素 (IL)-6，但不是肿瘤坏死因子α(TNF-α)或IL-1β，Jak依赖性激活Yap并诱导Yap-Snail相互作用。Yap敲低可防止IL-6激活或Snail过表达诱导的SF侵袭性，显示Yap在RA SF转化中的关键作用。

结论：这些研究结果揭示了炎症性关节炎中致病性SF中的IL-6-Yap-Snail信号通路。

出处：

Symons RA, Colella F, Collins FL, et al. Targeting the IL-6–Yap–Snail signalling axis in synovial fibroblasts ameliorates inflammatory arthritis. Annals of the Rheumatic Diseases 2022;81:214-224.

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2022-02-16 lilianxiang

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2022-11-05 gujh

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2022-02-08 ms920641618706883

#信号轴#

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encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Thu Jan 20 02:15:08 CST 2022, time=2022-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1273818, encodeId=4c4412e3818cc, content=<a href='/topic/show?id=fae896e7ea' target=_blank style='color:#2F92EE;'>#IL-6#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9677, encryptionId=fae896e7ea, topicName=IL-6)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f984116, createdName=kzlchina, createdTime=Thu Jan 20 02:15:08 CST 2022, time=2022-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1307178, encodeId=a7da130e17843, content=<a href='/topic/show?id=6dab540565f' target=_blank style='color:#2F92EE;'>#成纤维细胞#</a>, beContent=null, objectType=article, channel=null, 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href='/topic/show?id=c8e76e0205c' target=_blank style='color:#2F92EE;'>#炎症性关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67020, encryptionId=c8e76e0205c, topicName=炎症性关节炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=af0610859509, createdName=ms1756883563247400, createdTime=Thu Jan 20 02:15:08 CST 2022, time=2022-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547517, encodeId=0cff154e51762, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Thu Jan 20 02:15:08 CST 2022, time=2022-01-20, status=1, ipAttribution=)]
2022-01-20 lmm397

#关节炎#

35 0
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encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Thu Jan 20 02:15:08 CST 2022, time=2022-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1273818, encodeId=4c4412e3818cc, content=<a href='/topic/show?id=fae896e7ea' target=_blank style='color:#2F92EE;'>#IL-6#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9677, encryptionId=fae896e7ea, topicName=IL-6)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f984116, createdName=kzlchina, createdTime=Thu Jan 20 02:15:08 CST 2022, time=2022-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1307178, encodeId=a7da130e17843, content=<a href='/topic/show?id=6dab540565f' target=_blank style='color:#2F92EE;'>#成纤维细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54056, encryptionId=6dab540565f, topicName=成纤维细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5d70341, createdName=zhishijing, createdTime=Thu Jan 20 02:15:08 CST 2022, time=2022-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1462864, encodeId=6aed1462864e8, content=<a href='/topic/show?id=fbbce726228' target=_blank style='color:#2F92EE;'>#纤维细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77262, encryptionId=fbbce726228, topicName=纤维细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c516518840, createdName=marongnuan, createdTime=Thu Jan 20 02:15:08 CST 2022, time=2022-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1515748, encodeId=d5bb1515e4820, content=<a href='/topic/show?id=c8e76e0205c' target=_blank style='color:#2F92EE;'>#炎症性关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67020, encryptionId=c8e76e0205c, topicName=炎症性关节炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=af0610859509, createdName=ms1756883563247400, createdTime=Thu Jan 20 02:15:08 CST 2022, time=2022-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547517, encodeId=0cff154e51762, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Thu Jan 20 02:15:08 CST 2022, time=2022-01-20, status=1, ipAttribution=)]
2022-01-20 kzlchina

#IL-6#

49 0
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encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Thu Jan 20 02:15:08 CST 2022, time=2022-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1273818, encodeId=4c4412e3818cc, content=<a href='/topic/show?id=fae896e7ea' target=_blank style='color:#2F92EE;'>#IL-6#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9677, encryptionId=fae896e7ea, topicName=IL-6)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f984116, createdName=kzlchina, createdTime=Thu Jan 20 02:15:08 CST 2022, time=2022-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1307178, encodeId=a7da130e17843, content=<a href='/topic/show?id=6dab540565f' target=_blank style='color:#2F92EE;'>#成纤维细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54056, encryptionId=6dab540565f, topicName=成纤维细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5d70341, createdName=zhishijing, createdTime=Thu Jan 20 02:15:08 CST 2022, time=2022-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1462864, encodeId=6aed1462864e8, content=<a href='/topic/show?id=fbbce726228' target=_blank style='color:#2F92EE;'>#纤维细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77262, encryptionId=fbbce726228, topicName=纤维细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c516518840, createdName=marongnuan, createdTime=Thu Jan 20 02:15:08 CST 2022, time=2022-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1515748, encodeId=d5bb1515e4820, content=<a href='/topic/show?id=c8e76e0205c' target=_blank style='color:#2F92EE;'>#炎症性关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67020, encryptionId=c8e76e0205c, topicName=炎症性关节炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=af0610859509, createdName=ms1756883563247400, createdTime=Thu Jan 20 02:15:08 CST 2022, time=2022-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547517, encodeId=0cff154e51762, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Thu Jan 20 02:15:08 CST 2022, time=2022-01-20, status=1, ipAttribution=)]
2022-01-20 zhishijing

#成纤维细胞#

34 0
[GetPortalCommentsPageByObjectIdResponse(id=1794204, encodeId=49931e94204a7, content=<a href='/topic/show?id=9e0a164e4e4' target=_blank style='color:#2F92EE;'>#Snail#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16474, encryptionId=9e0a164e4e4, topicName=Snail)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=512a199, createdName=lilianxiang, createdTime=Wed Feb 16 07:15:08 CST 2022, time=2022-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2081930, encodeId=abc42081930ae, content=<a href='/topic/show?id=c2971893397' target=_blank style='color:#2F92EE;'>#YAP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18933, encryptionId=c2971893397, topicName=YAP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3333505, createdName=gujh, createdTime=Sat Nov 05 23:15:08 CST 2022, time=2022-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2006334, encodeId=6814200633474, content=<a href='/topic/show?id=64782e31314' target=_blank style='color:#2F92EE;'>#信号轴#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27313, encryptionId=64782e31314, topicName=信号轴)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aa5a2500103, createdName=ms920641618706883, createdTime=Tue Feb 08 19:15:08 CST 2022, time=2022-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1266397, encodeId=3cbf126639ed0, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Thu Jan 20 02:15:08 CST 2022, time=2022-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1273818, encodeId=4c4412e3818cc, content=<a href='/topic/show?id=fae896e7ea' target=_blank style='color:#2F92EE;'>#IL-6#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9677, encryptionId=fae896e7ea, topicName=IL-6)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f984116, createdName=kzlchina, createdTime=Thu Jan 20 02:15:08 CST 2022, time=2022-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1307178, encodeId=a7da130e17843, content=<a href='/topic/show?id=6dab540565f' target=_blank style='color:#2F92EE;'>#成纤维细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54056, encryptionId=6dab540565f, topicName=成纤维细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5d70341, createdName=zhishijing, createdTime=Thu Jan 20 02:15:08 CST 2022, time=2022-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1462864, encodeId=6aed1462864e8, content=<a href='/topic/show?id=fbbce726228' target=_blank style='color:#2F92EE;'>#纤维细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77262, encryptionId=fbbce726228, topicName=纤维细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c516518840, createdName=marongnuan, createdTime=Thu Jan 20 02:15:08 CST 2022, time=2022-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1515748, encodeId=d5bb1515e4820, content=<a href='/topic/show?id=c8e76e0205c' target=_blank style='color:#2F92EE;'>#炎症性关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67020, encryptionId=c8e76e0205c, topicName=炎症性关节炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=af0610859509, createdName=ms1756883563247400, createdTime=Thu Jan 20 02:15:08 CST 2022, time=2022-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547517, encodeId=0cff154e51762, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Thu Jan 20 02:15:08 CST 2022, time=2022-01-20, status=1, ipAttribution=)]
2022-01-20 marongnuan

#纤维细胞#

29 0
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createdName=gujh, createdTime=Sat Nov 05 23:15:08 CST 2022, time=2022-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2006334, encodeId=6814200633474, content=<a href='/topic/show?id=64782e31314' target=_blank style='color:#2F92EE;'>#信号轴#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27313, encryptionId=64782e31314, topicName=信号轴)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aa5a2500103, createdName=ms920641618706883, createdTime=Tue Feb 08 19:15:08 CST 2022, time=2022-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1266397, encodeId=3cbf126639ed0, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Thu Jan 20 02:15:08 CST 2022, time=2022-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1273818, encodeId=4c4412e3818cc, content=<a href='/topic/show?id=fae896e7ea' target=_blank style='color:#2F92EE;'>#IL-6#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9677, encryptionId=fae896e7ea, topicName=IL-6)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f984116, createdName=kzlchina, createdTime=Thu Jan 20 02:15:08 CST 2022, time=2022-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1307178, encodeId=a7da130e17843, content=<a href='/topic/show?id=6dab540565f' target=_blank style='color:#2F92EE;'>#成纤维细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54056, encryptionId=6dab540565f, topicName=成纤维细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5d70341, createdName=zhishijing, createdTime=Thu Jan 20 02:15:08 CST 2022, time=2022-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1462864, encodeId=6aed1462864e8, content=<a href='/topic/show?id=fbbce726228' target=_blank style='color:#2F92EE;'>#纤维细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77262, encryptionId=fbbce726228, topicName=纤维细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c516518840, createdName=marongnuan, createdTime=Thu Jan 20 02:15:08 CST 2022, time=2022-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1515748, encodeId=d5bb1515e4820, content=<a href='/topic/show?id=c8e76e0205c' target=_blank style='color:#2F92EE;'>#炎症性关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67020, encryptionId=c8e76e0205c, topicName=炎症性关节炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=af0610859509, createdName=ms1756883563247400, createdTime=Thu Jan 20 02:15:08 CST 2022, time=2022-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547517, encodeId=0cff154e51762, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Thu Jan 20 02:15:08 CST 2022, time=2022-01-20, status=1, ipAttribution=)]
2022-01-20 ms1756883563247400

#炎症性关节炎#

40 0
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createdName=gujh, createdTime=Sat Nov 05 23:15:08 CST 2022, time=2022-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2006334, encodeId=6814200633474, content=<a href='/topic/show?id=64782e31314' target=_blank style='color:#2F92EE;'>#信号轴#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27313, encryptionId=64782e31314, topicName=信号轴)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aa5a2500103, createdName=ms920641618706883, createdTime=Tue Feb 08 19:15:08 CST 2022, time=2022-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1266397, encodeId=3cbf126639ed0, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Thu Jan 20 02:15:08 CST 2022, time=2022-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1273818, encodeId=4c4412e3818cc, content=<a href='/topic/show?id=fae896e7ea' target=_blank style='color:#2F92EE;'>#IL-6#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9677, encryptionId=fae896e7ea, topicName=IL-6)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f984116, createdName=kzlchina, createdTime=Thu Jan 20 02:15:08 CST 2022, time=2022-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1307178, encodeId=a7da130e17843, content=<a href='/topic/show?id=6dab540565f' target=_blank style='color:#2F92EE;'>#成纤维细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54056, encryptionId=6dab540565f, topicName=成纤维细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5d70341, createdName=zhishijing, createdTime=Thu Jan 20 02:15:08 CST 2022, time=2022-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1462864, encodeId=6aed1462864e8, content=<a href='/topic/show?id=fbbce726228' target=_blank style='color:#2F92EE;'>#纤维细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77262, encryptionId=fbbce726228, topicName=纤维细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c516518840, createdName=marongnuan, createdTime=Thu Jan 20 02:15:08 CST 2022, time=2022-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1515748, encodeId=d5bb1515e4820, content=<a href='/topic/show?id=c8e76e0205c' target=_blank style='color:#2F92EE;'>#炎症性关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67020, encryptionId=c8e76e0205c, topicName=炎症性关节炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=af0610859509, createdName=ms1756883563247400, createdTime=Thu Jan 20 02:15:08 CST 2022, time=2022-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547517, encodeId=0cff154e51762, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Thu Jan 20 02:15:08 CST 2022, time=2022-01-20, status=1, ipAttribution=)]
2022-01-20 12498dd9m15暂无昵称

#炎症性#

22 0

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