JACC:收缩压更低的心衰伴射血分数降低患者预后更差

2019-06-24 不详 MedSci原创

国际指南推荐心衰伴射血分数降低(HFrEF)和高血压的患者收缩压(SBP)因低于130mmHg。本研究的目的旨在评估SBP <130 mm Hg和HFrEF患者预后的相关性。本研究纳入分析了心衰数据库中25345名患者,10535名患者射血分数≤40%,其中有5615名患者的SBP是稳定的,3805名患者出院时的SBP<130mmHg。基于58个基线临床特征,通过倾向性评分匹配到了1189对

国际指南推荐心衰伴射血分数降低(HFrEF)和高血压的患者收缩压(SBP)因低于130mmHg。本研究的目的旨在评估SBP <130 mm Hg和HFrEF患者预后的相关性。

本研究纳入分析了心衰数据库中25345名患者,10535名患者射血分数≤40%,其中有5615名患者的SBP是稳定的,3805名患者出院时的SBP<130mmHg。基于58个基线临床特征,通过倾向性评分匹配到了1189对SBP <130和≥130 mm Hg的患者(平均年龄76岁,平均射血分数28%,女性占45%)。分析结果显示,30天全因死亡率在SBP <130和≥130 mm Hg的患者中分别是7%和4%( [HR]: 1.76; 95%[CI]: 1.24-2.48; p = 0.001),与SBP <130mmHg相关的全因死亡率、全因再住院率和心衰再住院率的HR分别为1.32 (1.15-1.53; p < 0.001), 1.11 (1.01-1.23; p = 0.030)和1.24 (1.09-1.42; p = 0.001)。

研究结果显示,对于心衰伴射血分数降低的老年住院患者,收缩压<130mmHg与更差的预后相关,目前急需更多的临床随机对照试验探究心衰伴射血分数降低患者的理想收缩压。

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    2020-02-06 hbwxf
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    2019-06-24 329523732

    不错

    0

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