J Periodontol:白细胞介素-22对人牙周膜成纤维细胞成骨分化和破骨反应的影响

2020-08-23 MedSci原创 MedSci原创

白细胞介素-22(IL-22)具有广泛的生物学效应,在自身免疫性疾病和感染性疾病中既起保护作用又起病理作用。但IL-22在牙周炎发病过程中的具体作用和机制尚未明确。

白细胞介素-22(IL-22)具有广泛的生物学效应,在自身免疫性疾病和感染性疾病中既发挥保护作用又起病理作用。但IL-22在牙周炎发病过程中的具体作用和机制尚未明确。本研究旨在分析IL-22在牙周炎的破骨细胞发生和成骨过程中可能的作用。

研究使用IL-22和/或牙龈卟啉菌的脂多糖(Pg-LPS)处理人牙周膜成纤维细胞(hPDLFs),分别用qRT-PCR和Western blotting检测RANKL和OPG的mRNA和蛋白表达。Western blotting检测MAPK信号分子的磷酸化和总蛋白表达。通过抑制实验进一步检测MAPK通路在成骨标志物表达中的作用。在成骨方面,通过qRT-PCR定量检测成骨标志物的mRNA表达,通过ALP测定法检测hPDLFs的碱性磷酸酶(ALP)活性,通过Alizarin Red S染色检测hPDLFs形成的钙结节。

结果发现,IL-22通过MAPK信号通路促进hPDLFs中RANKL的表达,并与Pg-LPS一起通过p38 MAPK通路进一步上调RANKL的表达。IL-22可以增强hPDLFs在成骨诱导早期的ALP活性和钙结节的形成,而对成骨标志物的表达没有显著影响。

本研究表明,IL-22在骨代谢中起着调节作用,它很可能作为一种促炎细胞因子在牙周炎的发病过程中起到促进破骨细胞生成的作用。

原文出处:

Chuanjiang Zhao, Effect of interleukin‐22 on osteogenic differentiation and the osteoclastogenic response of human periodontal ligament fibroblasts in vitro,Journal of Periodontology,2020,8.

 

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    2020-12-28 HinsMax
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createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/qXbLjJB4FSzhQS3C5qQFMJkqicRIJFL6zHFwwhv0I95nzA6xicevQcEica0gk4A58UkbMMriadAgTY2b7N7Yd0ZsQg/132, createdBy=910c2500152, createdName=HinsMax, createdTime=Mon Dec 28 09:48:19 CST 2020, time=2020-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1728643, encodeId=9a401e286439b, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu Mar 25 03:48:19 CST 2021, time=2021-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1755938, encodeId=320a1e559380e, content=<a href='/topic/show?id=30f46e536d7' target=_blank style='color:#2F92EE;'>#牙周膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67536, encryptionId=30f46e536d7, topicName=牙周膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a6e37060729, createdName=xqptu, createdTime=Thu Sep 03 11:48:19 CST 2020, time=2020-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=885720, encodeId=4e8a885e2097, content=学习了很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200916/50a2ba5dd9924942a26ed15b2c605415/243db257aaa8444ca62a887ec28e7389.jpg, createdBy=fc125412930, createdName=ms3000001642630817, createdTime=Wed Sep 16 10:54:34 CST 2020, time=2020-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=814168, encodeId=efea8141686a, content=标记一下 学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8ce05381686, createdName=ms4000002082197205, createdTime=Thu Aug 27 17:47:57 CST 2020, time=2020-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1307155, encodeId=01c1130e15504, content=<a href='/topic/show?id=6dab540565f' target=_blank style='color:#2F92EE;'>#成纤维细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54056, encryptionId=6dab540565f, topicName=成纤维细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5d70341, createdName=zhishijing, createdTime=Tue Aug 25 13:48:19 CST 2020, time=2020-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1337601, encodeId=d525133e601dd, content=<a href='/topic/show?id=863f5409610' target=_blank style='color:#2F92EE;'>#成骨分化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54096, encryptionId=863f5409610, topicName=成骨分化)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqySEUYKeYDjXJMYMrtscBNkpAnLfQZgDcdkEratcJPqS7ARJOXqllZQhCSFicErlBFbIywuoiaP0LQ/132, createdBy=012d2500132, createdName=ms5880526374914242, createdTime=Tue Aug 25 13:48:19 CST 2020, time=2020-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1352247, encodeId=7001135224e40, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Aug 25 13:48:19 CST 2020, time=2020-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1451320, encodeId=a12f1451320f0, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Tue Aug 25 13:48:19 CST 2020, time=2020-08-25, status=1, ipAttribution=)]
    2020-09-03 xqptu
  5. [GetPortalCommentsPageByObjectIdResponse(id=1800113, encodeId=55c71800113ba, content=<a href='/topic/show?id=2762e172079' target=_blank style='color:#2F92EE;'>#白细胞介素-2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71720, encryptionId=2762e172079, topicName=白细胞介素-2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3dd32500118, createdName=644982816_68283321, createdTime=Sun Aug 01 23:48:19 CST 2021, time=2021-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1821459, encodeId=f6431821459ff, content=<a href='/topic/show?id=428a101612e7' target=_blank style='color:#2F92EE;'>#骨分化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101612, encryptionId=428a101612e7, topicName=骨分化)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/qXbLjJB4FSzhQS3C5qQFMJkqicRIJFL6zHFwwhv0I95nzA6xicevQcEica0gk4A58UkbMMriadAgTY2b7N7Yd0ZsQg/132, createdBy=910c2500152, createdName=HinsMax, createdTime=Mon Dec 28 09:48:19 CST 2020, time=2020-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1728643, encodeId=9a401e286439b, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu Mar 25 03:48:19 CST 2021, time=2021-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1755938, encodeId=320a1e559380e, content=<a href='/topic/show?id=30f46e536d7' target=_blank style='color:#2F92EE;'>#牙周膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67536, encryptionId=30f46e536d7, topicName=牙周膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a6e37060729, createdName=xqptu, createdTime=Thu Sep 03 11:48:19 CST 2020, time=2020-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=885720, encodeId=4e8a885e2097, content=学习了很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200916/50a2ba5dd9924942a26ed15b2c605415/243db257aaa8444ca62a887ec28e7389.jpg, createdBy=fc125412930, createdName=ms3000001642630817, createdTime=Wed Sep 16 10:54:34 CST 2020, time=2020-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=814168, encodeId=efea8141686a, content=标记一下 学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8ce05381686, createdName=ms4000002082197205, createdTime=Thu Aug 27 17:47:57 CST 2020, time=2020-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1307155, encodeId=01c1130e15504, content=<a href='/topic/show?id=6dab540565f' target=_blank style='color:#2F92EE;'>#成纤维细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54056, encryptionId=6dab540565f, topicName=成纤维细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5d70341, createdName=zhishijing, createdTime=Tue Aug 25 13:48:19 CST 2020, time=2020-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1337601, encodeId=d525133e601dd, content=<a href='/topic/show?id=863f5409610' target=_blank style='color:#2F92EE;'>#成骨分化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54096, encryptionId=863f5409610, topicName=成骨分化)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqySEUYKeYDjXJMYMrtscBNkpAnLfQZgDcdkEratcJPqS7ARJOXqllZQhCSFicErlBFbIywuoiaP0LQ/132, createdBy=012d2500132, createdName=ms5880526374914242, createdTime=Tue Aug 25 13:48:19 CST 2020, time=2020-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1352247, encodeId=7001135224e40, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Aug 25 13:48:19 CST 2020, time=2020-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1451320, encodeId=a12f1451320f0, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Tue Aug 25 13:48:19 CST 2020, time=2020-08-25, status=1, ipAttribution=)]
    2020-09-16 ms3000001642630817

    学习了很多

    0

  6. 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style='color:#2F92EE;'>#牙周膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67536, encryptionId=30f46e536d7, topicName=牙周膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a6e37060729, createdName=xqptu, createdTime=Thu Sep 03 11:48:19 CST 2020, time=2020-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=885720, encodeId=4e8a885e2097, content=学习了很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200916/50a2ba5dd9924942a26ed15b2c605415/243db257aaa8444ca62a887ec28e7389.jpg, createdBy=fc125412930, createdName=ms3000001642630817, createdTime=Wed Sep 16 10:54:34 CST 2020, time=2020-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=814168, 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encodeId=d525133e601dd, content=<a href='/topic/show?id=863f5409610' target=_blank style='color:#2F92EE;'>#成骨分化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54096, encryptionId=863f5409610, topicName=成骨分化)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqySEUYKeYDjXJMYMrtscBNkpAnLfQZgDcdkEratcJPqS7ARJOXqllZQhCSFicErlBFbIywuoiaP0LQ/132, createdBy=012d2500132, createdName=ms5880526374914242, createdTime=Tue Aug 25 13:48:19 CST 2020, time=2020-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1352247, encodeId=7001135224e40, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Aug 25 13:48:19 CST 2020, time=2020-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1451320, encodeId=a12f1451320f0, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Tue Aug 25 13:48:19 CST 2020, time=2020-08-25, status=1, ipAttribution=)]
    2020-08-27 ms4000002082197205

    标记一下 学习了

    0

  7. 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  8. 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    2020-08-25 zhaojie88
  10. 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牙周炎的症状,比如牙龈红肿、酸痛,刷牙时流血。如果控制不佳或不加以治疗,炎症进一步加剧还会造成牙齿支撑组织的退化,进而导致牙齿松动和脱落。此外,牙周炎与一系列全身性疾病相关,包括糖尿病、心血管疾病等。

J Periodontol:种植体周围炎的发生率

种植体周围炎的发病率与功能负荷时间成正比。本回顾性研究的目的是评估有牙周炎病史的患者和功能负荷1~10年的种植体的存活率、成功率以及种植体周围炎的发生率。

J Periodontol:患者自我报告牙周炎的有效性

临床检查是检测牙周炎的金标准,然而,临床检测需要大量资源。已经有研究开发了几种自我报告的方法,并在不同的场景中进行了测试,结果提示,这可能是在不同人群中筛查牙周病的有用工具。

J Periodontol:可卡因和多物质滥用对口腔健康的影响

可卡因是美国第二大非法滥用药物。但是迄今为止,还没有任何研究以全国代表性的样本来分析可卡因使用与口腔健康之间的关系。本研究考察了美国成年人中可卡因单独使用或与其他物质一起使用对口腔健康的影响.

J Periodontol:黄酮类饮食摄入量和牙周炎的风险

由于相关的抗炎作用,富含黄酮类食物和饮料可能会潜在地影响牙周病的发生率。本实验旨在研究习惯性黄酮类物质摄入量与牙周炎发病率之间的关系。

J Periodontal Res:褪黑激素可作为慢性牙周炎的一种辅助治疗手段

褪黑素是由松果体自然合成的,负责调节睡眠/觉醒周期。褪黑素具有优越的抗炎和抗氧化特性。这项随机临床试验(RCT)旨在评估褪黑素补充剂对伴有广泛性慢性牙周炎(gCP)的失眠患者洁治和根部平整(SRP)后