Diabetes Care:1型糖尿病患者脂蛋白(a)水平与心血管疾病患病率和代谢控制状态的关系

2019-12-24 xing.T MedSci原创

由此可见,Lp(a)是1型糖尿病患者大血管疾病、白蛋白尿和钙化主动脉瓣膜疾病的重要危险因素。1型糖尿病患者的代谢控制不良与Lp(a)水平升高有关。

近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,研究人员旨在探讨1型糖尿病患者心血管危险因子脂蛋白(a)[Lp(a)]与血管并发症之间的关系。

在本观察性横断面研究中,研究人员招募了接受常规治疗的1型糖尿病患者,并根据其Lp(a)水平将其分为四组(极低<10;低10-30;中等30-120;高>120nmol/L)。研究人员比较了两组之间血管并发症发生率。此外,研究人员探究了代谢控制(以HbA1c水平来衡量)与Lp(a)之间的关联。

患者(n=1860)的中位年龄为48岁,糖尿病病程为25年,HbA1c为7.8%(61 mmol/mol)。 Lp(a)中位数(四分位数范围)为19(10-71)nmol/L。研究人员没有观察到男女之间的显著差异,但是Lp(a)的水平随着年龄的增长而增加。高脂蛋白(a)组患者并发症发生率高于低脂蛋白(a)组患者。大血管疾病患者调整年龄和吸烟状况后相对风险比为1.51(置信区间,CI为1.01-2.28,p=0.048),冠心病患者为1.70(CI为0.97-3.00,p=0.063),蛋白尿患者为1.68(CI为1.12-2.50,p=0.01)和钙化的主动脉瓣疾病患者为2.03(CI为1.03-4.03; p=0.042)。代谢控制良好且HbA1c<6.9%(<52mmol/mol)的患者Lp(a)水平明显低于代谢控制较差的HbA1c>6.9%(>52mmol/mol)的患者。

由此可见,Lp(a)是1型糖尿病患者大血管疾病、白蛋白尿和钙化主动脉瓣膜疾病的重要危险因素。1型糖尿病患者的代谢控制不良与Lp(a)水平升高有关。

原始出处:

Karin Littmann.et al.The Association of Lipoprotein(a) Plasma Levels with Prevalence of Cardiovascular Disease and Metabolic Control Status in Patients with Type 1 Diabetes Mellitus.Diabetes Care.2019.https://care.diabetesjournals.org/content/early/2019/12/19/dc19-1398

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    2019-12-26 xinmeili
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    2019-12-24 misszhang

    谢谢MedSci提供最新的资讯

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