Clin Trans Gastroenterology:结肠镜检查与粪便免疫化学联合测试可降低结直肠癌风险

2021-05-06 MedSci原创 MedSci原创

大肠癌(CRC)是全球第三大最常见的癌症,已经成为一个日益重要的公共卫生问题。

      大肠癌(CRC)是全球第三大最常见的癌症,已经成为一个日益重要的公共卫生问题。因此,许多国家已经制定了筛查计划以降低CRC的发生率,但是,全世界的筛查方案相差很大。粪便免疫化学测试(FITs),乙状结肠镜检查和结肠镜检查是使用最广泛的筛查程序。但是,目前尚不清楚哪种方法可以最有效地降低CRC相关发病率。先前的研究支持使用结肠镜检查或粪便免疫化学测试(FIT)预防大肠癌(CRC)的发生。但是,关于结肠镜检查或FIT降低CRC风险的比较有效性的具体证据很少。在这项研究中,研究人员使用全国性数据库比较了CRC风险与结肠镜检查和FIT的相关性。

 

       本项病例对照研究使用了2002年至2013年韩国国家健康保险系统中的接受结肠镜检查和FIT检测的患者的临床数据,总共分析了来自61,221例新诊断为CRC的患者(病例组)和306,099例无CRC的个体(对照组)的临床数据。多变量logistic回归模型用于评估CRC与结肠镜检查或FIT之间的关联。

 

       研究结果显示结肠镜检查与CRC风险的降低相关([OR] 0.29)。与近端CRC相比,结肠镜检查与远端CRC之间的关联更强(0.24 VS 0.47)。在按性别分层的分析中,女性受试者的关联性较男性受试者弱(0.33 VS 0.27)。任何FIT检测都与CRC风险降低相关,OR为0.74;对于远端癌,这种关联更强。随着累积FIT评估频率的增加(从1到≥5),CRC的FIT暴露OR逐渐从0.81降低到0.45。

图:结肠镜与粪便免疫检测对于CRC的发病率影响

      由此可见结肠镜检查或FIT检测都能降低CRC风险,而且这种关联对于远端CRC比近端CRC更强。

 

 

原始出处:

Kim, Su Young. Et al. Colonoscopy Versus Fecal Immunochemical Test for Reducing Colorectal Cancer Risk: A Population-Based Case–Control Study. Clinical and Translational Gastroenterology.2021.

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createdBy=c54a30977679, createdName=lfyang, createdTime=Tue Nov 23 18:23:01 CST 2021, time=2021-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1712796, encodeId=1d811e12796f0, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Fri Nov 05 19:23:01 CST 2021, time=2021-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2073330, encodeId=166e20e3330cb, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, 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time=2021-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1453504, encodeId=0a4c1453504c7, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Sat May 08 13:23:01 CST 2021, time=2021-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1466967, encodeId=0369146696eba, content=<a href='/topic/show?id=edd5e630426' target=_blank style='color:#2F92EE;'>#粪便#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76304, encryptionId=edd5e630426, topicName=粪便)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=03cc6863823, createdName=Homburg, createdTime=Sat May 08 13:23:01 CST 2021, time=2021-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1505246, encodeId=fb6415052466d, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Sat May 08 13:23:01 CST 2021, time=2021-05-08, status=1, ipAttribution=)]
    2021-12-24 许安
  5. 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time=2021-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1453504, encodeId=0a4c1453504c7, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Sat May 08 13:23:01 CST 2021, time=2021-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1466967, encodeId=0369146696eba, content=<a href='/topic/show?id=edd5e630426' target=_blank style='color:#2F92EE;'>#粪便#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76304, encryptionId=edd5e630426, topicName=粪便)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=03cc6863823, createdName=Homburg, createdTime=Sat May 08 13:23:01 CST 2021, time=2021-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1505246, encodeId=fb6415052466d, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Sat May 08 13:23:01 CST 2021, time=2021-05-08, status=1, ipAttribution=)]
    2022-01-25 bsmagic9140
  6. 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attachment=null, authenticateStatus=null, createdAvatar=, createdBy=03cc6863823, createdName=Homburg, createdTime=Sat May 08 13:23:01 CST 2021, time=2021-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1505246, encodeId=fb6415052466d, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Sat May 08 13:23:01 CST 2021, time=2021-05-08, status=1, ipAttribution=)]
    2021-06-15 sjq027
  7. 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    2021-05-08 zhouqu_8
  8. 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  9. 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    2021-05-08 Homburg
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胃肠道(GI)内镜检查在胃肠道疾病的诊断和治疗中起着越来越重要的作用。但是,这些操作可能与身体不适,疼痛和焦虑有关。

Clin Gastroenterology H: 粪便免疫化学检测阳性后结肠镜检查时间与结直肠癌结果之间的关联

在对大肠癌(CRC)患者进行粪便筛查试验阳性之后,需要可疑患者进行结肠镜检查明确诊断。单目前尚不清楚结肠镜检查的时间与CRC相关结果相关的程度。本项研究对此进行了系统风险阐明这种关系。

GUT:术后结肠镜复查间隔对结肠息肉切除患者晚期病变风险的影响

对于连续2轮术后肠镜复查结果阴性的肠道息肉切除患者,间隔复查时间可延长至3年1次

Gastroenterology :45岁后要定期做肠镜

45-49岁时接受结肠镜检查与随后的大肠癌发病率显著降低有很强的相关性。