JAMA子刊:非侵入性脑刺激干预对精神分裂症阴性症状的影响

2022-06-29 MedSci原创 MedSci原创

左背外侧前额叶皮层的兴奋性NIBS方案与消极症状严重程度的明显大的改善有关。

精神分裂症阴性症状对患者的功能结果和生活质量有不利的影响,而且很少有治疗方案被认为对这一症状层面有效。研究表明,无创脑刺激(NIBS)干预措施可能对治疗消极症状有效。然而,不同的NIBS方案对缓解消极症状的疗效比较仍不清楚。

为了比较不同NIBS干预措施对治疗消极症状的疗效和可接受性,来自我国台湾的学者开展了一项meta分析。对ClinicalKey、Cochrane CENTRAL、Embase、ProQuest、PubMed、ScienceDirect、ClinicalTrials.gov和Web of Science等电子数据库进行系统性检索。

该网络荟萃分析以评估评价重复经颅磁刺激(rTMS)、θ-突发刺激、经颅随机噪声刺激、经皮迷走神经刺激和经颅直流电刺激对精神分裂症阴性症状疗效的试验结果的汇总。研究对精神分裂症患者进行NIBS干预的随机临床试验(RCTs)被包括在内。

结果涉及2211名参与者(平均[范围]年龄,38.7[24.0-57.0]岁;女性患者的平均[范围]比例,30.6%[0%-70.0%])的48项RCT被纳入。与假对照干预相比,兴奋性NIBS策略(差异[SMD]:高清晰度经颅随机噪声刺激,-2.19[95%CI,-3.36至-1.02];间歇性θ爆发刺激,-1.32[95%CI,-1.88至-0.76];正极经颅直接电流刺激,-1.28[95%CI,-2.55至-0. 02];高频经颅磁刺激,-0.43[95%CI,-0.68至-0.18];极端高频经颅磁刺激,-0.45[95%CI,-0.79至-0.12])在左背外侧前额叶皮层上进行或不进行大脑对侧区域的其他抑制性刺激方案,与消极症状的明显减少有关。各组之间的可接受性没有明显差异。

综上,在这个网络荟萃分析中,左背外侧前额叶皮层的兴奋性NIBS方案与消极症状严重程度的明显大的改善有关。

 

参考文献:

Assessment of Noninvasive Brain Stimulation Interventions for Negative Symptoms of Schizophrenia: A Systematic Review and Network Meta-analysis . JAMA Psychiatry. Published online June 22, 2022. doi:10.1001/jamapsychiatry.2022.1513

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    2022-06-27 amyloid
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    2022-06-25 肿瘤克星

    JAMA上文章都是顶级的,谢谢梅斯及时上新

    0

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