Pediatrics:宝妈注意啦!两岁前宝宝使用抗菌药物增加儿童肥胖风险

2018-11-28 吴星 环球医学

抗菌药物滥用往往会导致种种恶果。2018年10月,发表在《Pediatrics》的一项大型儿童队列研究就表明,两岁前宝宝抗菌药物使用的增加与5岁时体重略微较高相关。

抗菌药物滥用往往会导致种种恶果。2018年10月,发表在《Pediatrics》的一项大型儿童队列研究就表明,两岁前宝宝抗菌药物使用的增加与5岁时体重略微较高相关。

目的:在一项大型儿童队列中,考察抗菌药物使用与体重结局之间的相关性。

方法:研究人员获得2009~2016年参加以患者为中心的临床研究网络的35家机构的卫生保健数据。患者纳入要求:年龄在0~<12、12~<30、48~<72个月,同一天测量身高和体重。研究人员评价了24个月以内任何抗菌药的使用与48~<72个月(5岁)根据BMI z评分超重或肥胖之间的相关性,次要指标评价抗菌药物的抗菌谱以及年龄-暴露时长。研究人员纳入有或无合并慢性病的儿童。

结果:在年龄<12个月同一天测量身高和体重的1792849例儿童中,362550例符合队列的纳入标准。一半儿童(52%)为男孩,27%为非裔美国人,18%为西班牙裔,58%在<24个月时接受≥1个抗菌药物处方。5岁时,平均BMI z评分为0.40(SD 1.19),28%的儿童超重或肥胖。在5岁无复杂慢性疾病儿童的校正模型中,研究人员估算BMI z评分高出0.04(95%置信区间[CI] 0.03~0.05),以及较高的超重或肥胖几率(比值比1.05;95% CI 1.03~1.07)与<24个月时使用任何(与不使用相比)抗菌药物相关。

结论:<24个月时使用抗菌药物与5岁时体重略微较高相关。

原始出处:

Block JP, Bailey LC, Gillman MW, et al. Early Antibiotic Exposure and Weight Outcomes in Young Children. Pediatrics. 2018 Oct 31. pii: e20180290. doi: 10.1542/peds.2018-0290.

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    2019-05-29 feather89
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    2019-05-12 hbwxf
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1638871, encodeId=3b6916388e170, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Jan 26 17:57:00 CST 2019, time=2019-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727756, encodeId=171c1e2775698, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Wed May 29 23:57:00 CST 2019, time=2019-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1958541, encodeId=056919585413d, content=<a href='/topic/show?id=766713993a1' target=_blank style='color:#2F92EE;'>#Pediatric#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13993, encryptionId=766713993a1, topicName=Pediatric)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Sun May 12 04:57:00 CST 2019, time=2019-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1330782, encodeId=cc4c1330e82d4, content=<a href='/topic/show?id=c6b455688d1' target=_blank style='color:#2F92EE;'>#抗菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55688, encryptionId=c6b455688d1, topicName=抗菌)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/2898B09F0DA89357D0D54A725E611AC7/100, createdBy=fdd32500040, createdName=ms7899726347904398, createdTime=Thu Nov 29 15:57:00 CST 2018, time=2018-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1373098, encodeId=cc6113e30989d, content=<a href='/topic/show?id=eb2555e176c' target=_blank style='color:#2F92EE;'>#抗菌药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55717, encryptionId=eb2555e176c, topicName=抗菌药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7e12358, createdName=lhlxtx, createdTime=Thu Nov 29 15:57:00 CST 2018, time=2018-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1552868, encodeId=952d15528688a, content=<a href='/topic/show?id=59d628408fa' target=_blank style='color:#2F92EE;'>#儿童肥胖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28408, encryptionId=59d628408fa, topicName=儿童肥胖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06814304969, createdName=windight, createdTime=Thu Nov 29 15:57:00 CST 2018, time=2018-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=353846, encodeId=8f0e35384603, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1bb241978, createdName=phoebeyan520, createdTime=Wed Nov 28 07:59:11 CST 2018, time=2018-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1249841, encodeId=a9301249841d6, content=<a href='/topic/show?id=95264599452' target=_blank style='color:#2F92EE;'>#宝宝#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45994, encryptionId=95264599452, topicName=宝宝)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=杏林小小, createdTime=Wed Nov 28 03:57:00 CST 2018, time=2018-11-28, status=1, ipAttribution=)]
    2018-11-29 lhlxtx
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    2018-11-28 phoebeyan520

    学习了

    0

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