EMBO Rep :喝茶也能抗艾滋?复旦大学发现绿茶提取物能抑制HIV病毒复制

2020-09-23 生物世界 Bio生物世界

艾滋病(AIDS)是由人类获得性免疫缺陷病毒(HIV)引起的一种人类免疫缺陷疾病,由于一直缺乏有效的治愈手段,当前主要通过抗逆转录病毒疗法(ART)来控制HIV的复制和感染,但这并不能彻底治愈艾滋病。

艾滋病(AIDS)是由人类获得性免疫缺陷病毒(HIV)引起的一种人类免疫缺陷疾病,由于一直缺乏有效的治愈手段,当前主要通过抗逆转录病毒疗法(ART)来控制HIV的复制和感染,但这并不能彻底治愈艾滋病,一旦停药,HIV病毒会立刻反扑,此外,HIV耐药性问题也日益突出。

茶是全球最受欢迎的饮料之一,尤其是在中国,许多研究表明,喝茶具有多种潜在益处,尤其是对动脉粥样硬化性血管疾病(ASCVD)的潜在益处已引起了公众和研究人员的极大关注。2020年1月,顾东风院士在《欧洲预防心脏病学杂志》发表研究论文,表明每周至少喝三次茶与更健康和更长的预期寿命有关。

近日,复旦大学遗传工程国家重点实验室朱焕章教授领导的研究团队在 EMBO Reports 杂志在线发表了题为:PEBP1 suppresses HIV transcription and induces latency by inactivating MAPK/NF-κB signaling 的研究论文。

这项研究确定了磷脂酰乙醇胺结合蛋白1(PEBP1)是一种可以诱导HIV休眠的新基因。更重要的是,研究团队还发现绿茶提取物EGCG可以诱导激活PEBP1,进而PEBP1再通过抑制HIV的转录和失活MAPK/NF-κB信号通路促使HIV继续潜伏。

论文作者表示,对这一通路的的靶向治疗或将成为控制HIV患者发病进程的新选择。

艾滋病之所以难以治愈,不仅在于HIV病毒为RNA病毒,突变速度极快,还在于HIV病毒可以整合并潜伏于宿主细胞内,这成为了消灭HIV病毒的主要障碍。但遗憾的是,目前我们对HIV如何建立潜伏期的认知不多。

由此看来,探究HIV病毒潜伏期建立过程,并开发相应的靶向治疗方法对控制艾滋病患者疾病进程十分关键。

在此项研究中,研究人员使用高复杂性和全基因组sgRNA库,对艾滋病潜伏感染模型的CD4+ T细胞进行了全基因组CRISPR‐Cas9敲除文库筛选。在富集到的基因中,研究团队发现PEBP1基因可以抑制HIV复制,并促进HIV潜伏期的建立。

全基因组CRISPR筛选策略

PEBP1,也称Raf激酶抑制蛋白(RKIP),它可以与Raf-1结合从而抑制MAPK信号转导通路,并参与了对G蛋白偶联受体信号通路和NF-κB信号通路的调控,在膜的生物合成、神经发育和细胞凋亡等生理过程中发挥重要作用。

进一步研究表明,当敲除PEBP1基因后,Raf1/ERK/IκB和IKK/IκB/NF‐κB信号通路被激活,进而导致潜伏期HIV的复苏。这一结果在多个HIV潜伏期模型中均得到验证,包括HIV潜伏期的原代CD4+ T细胞模型。

PEBP1通过失活Raf1/IKK/NF‐κB信号通路抑制HIV-1的重新激活

该论文的第一作者杨新毅表示,PEBP1可以直接抑制HIV‐1感染,并在原代CD4+ T细胞中诱导HIV进入潜伏期,更重要的是,这项研究发现PEBP1可以被一种从中国人常喝的绿茶中提取的小分子物质EGCG诱导激活。”

EGCG诱导的PEBP1抑制潜伏期HIV病毒的重新激活

EGCG(Epigallocatechin gallate),即表没食子儿茶素没食子酸酯,是绿茶茶多酚的主要组成成分,有研究表明,EGCG具有抗菌、抗病毒、抗氧化、抗动脉硬化、抗血栓形成、抗血管增生、抗炎以及抗肿瘤等多种功效。

研究人员还发现,当PEBP1被EGCG诱导激活后,可以抑制核易位NF-κB,进而抑制潜伏期HIV病毒的重新激活——这些HIV病毒分离自那些接受了抗逆转录病毒治疗的HIV阳性患者的原代CD4+ T细胞。

PEBP1在HIV潜伏期建立中发挥重要作用

总而言之,上述研究事实表明PEBP1在控制HIV病毒转录和潜伏期建立中发挥着关键作用,该研究为人类认知HIV潜伏期的建立机制提供了新的见解。与此同时,朱焕章教授也表示,他们的研究表明绿茶提取物EGCG或可成为未来治疗干预艾滋病潜伏期患者的新选择!

特别说明:生物世界公众号仅如实报道何解读最新研究论文,并不构成保健或医疗指导,凡事过犹不及,喝茶也并非百利而无一害,应根据自身情况,合理适度饮茶。

原始出处:

Xinyi Yang, Yanan Wang, Panpan Lu, et al.PEBP1 suppresses HIV transcription and induces latency by inactivating MAPK/NF-κB signaling.EMBO Rep. 2020 Sep 14;e49305. doi: 10.15252/embr.201949305.

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    2020-12-07 ms9000001141432276

    太给力了

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    2020-09-28 YS出品

    0

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objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42660, encryptionId=751e42660f1, topicName=复旦)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6c312994908, createdName=saikp, createdTime=Fri Sep 25 07:00:55 CST 2020, time=2020-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887880, encodeId=a05f88e8804e, content=嘿嘿、我喜欢喝茶, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220301/6252e946e5ef413b86dc0f7d1f73b6db/9a7e8c88a38e487b8da4968a67bbd261.png, createdBy=b9f692910, createdName=rayms, createdTime=Thu Sep 24 10:19:05 CST 2020, time=2020-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887877, encodeId=a78488e877b7, content=这也可以吗?努力吧<a href='/topic/show?id=aa0582e6946' target=_blank style='color:#2F92EE;'>#肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=167, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82769, encryptionId=aa0582e6946, topicName=肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0d4d2326628, createdName=1225f870m98(暂无昵称), createdTime=Thu Sep 24 10:10:14 CST 2020, time=2020-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887841, encodeId=2a3c88e841df, content=不是很靠谱, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200923/1127ba78eea04b1881bce424b58205b4/4bd4943b16264509a3ef9068dfa83150.jpg, createdBy=f73c5420857, createdName=ms3000000222172370, createdTime=Thu Sep 24 08:48:30 CST 2020, time=2020-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887774, encodeId=0a2c88e7744d, content=还是好好吃饭,提高自己的自身免疫力最靠谱!, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Wed Sep 23 21:31:40 CST 2020, time=2020-09-23, status=1, ipAttribution=)]
    2020-09-25 hbwxf
  4. [GetPortalCommentsPageByObjectIdResponse(id=905575, encodeId=78929055e5ae, content=太给力了, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e26b5442082, createdName=ms9000001141432276, createdTime=Mon Dec 07 01:22:37 CST 2020, time=2020-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=888894, encodeId=002e8888947e, content=牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eohaPibNmxiaAxe7H2PbNMiaAThPR6wVlN52bo7M6QPFLzto3RvuJvzaVRUKLSWhiaibjsTImrk9BOkM9Q/132, createdBy=0e735307422, createdName=YS出品, createdTime=Mon Sep 28 13:26:38 CST 2020, time=2020-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1402401, encodeId=c4a31402401ae, content=<a href='/topic/show?id=862e8e196a1' target=_blank style='color:#2F92EE;'>#茶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87196, encryptionId=862e8e196a1, topicName=茶)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/eTyQ1TyLVfyaGrflWSd1Jw4u1F68ibicmN32DE38FjEW3zTIKeFeaMUAQsjyqaL4QZ3lRibFIzziacMz9niceznOTTw/132, createdBy=03082405249, createdName=hbwxf, createdTime=Fri Sep 25 07:00:55 CST 2020, time=2020-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1412643, encodeId=ecab1412643de, content=<a href='/topic/show?id=32ec89220b' target=_blank style='color:#2F92EE;'>#HIV病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8922, encryptionId=32ec89220b, topicName=HIV病毒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fa102876871, createdName=tigerlr99, createdTime=Fri Sep 25 07:00:55 CST 2020, time=2020-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512367, encodeId=ea78151236eca, content=<a href='/topic/show?id=6a15e09150c' target=_blank style='color:#2F92EE;'>#病毒复制#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70915, encryptionId=6a15e09150c, topicName=病毒复制)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1a2310462124, createdName=12498623m96暂无昵称, createdTime=Fri Sep 25 07:00:55 CST 2020, time=2020-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1538596, encodeId=8ed415385969b, content=<a href='/topic/show?id=751e42660f1' target=_blank style='color:#2F92EE;'>#复旦#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42660, encryptionId=751e42660f1, topicName=复旦)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6c312994908, createdName=saikp, createdTime=Fri Sep 25 07:00:55 CST 2020, time=2020-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887880, encodeId=a05f88e8804e, content=嘿嘿、我喜欢喝茶, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220301/6252e946e5ef413b86dc0f7d1f73b6db/9a7e8c88a38e487b8da4968a67bbd261.png, createdBy=b9f692910, createdName=rayms, createdTime=Thu Sep 24 10:19:05 CST 2020, time=2020-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887877, encodeId=a78488e877b7, content=这也可以吗?努力吧<a href='/topic/show?id=aa0582e6946' target=_blank style='color:#2F92EE;'>#肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=167, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82769, encryptionId=aa0582e6946, topicName=肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0d4d2326628, createdName=1225f870m98(暂无昵称), createdTime=Thu Sep 24 10:10:14 CST 2020, time=2020-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887841, encodeId=2a3c88e841df, content=不是很靠谱, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200923/1127ba78eea04b1881bce424b58205b4/4bd4943b16264509a3ef9068dfa83150.jpg, createdBy=f73c5420857, createdName=ms3000000222172370, createdTime=Thu Sep 24 08:48:30 CST 2020, time=2020-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887774, encodeId=0a2c88e7744d, content=还是好好吃饭,提高自己的自身免疫力最靠谱!, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Wed Sep 23 21:31:40 CST 2020, time=2020-09-23, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=905575, encodeId=78929055e5ae, content=太给力了, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e26b5442082, createdName=ms9000001141432276, createdTime=Mon Dec 07 01:22:37 CST 2020, time=2020-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=888894, encodeId=002e8888947e, content=牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eohaPibNmxiaAxe7H2PbNMiaAThPR6wVlN52bo7M6QPFLzto3RvuJvzaVRUKLSWhiaibjsTImrk9BOkM9Q/132, createdBy=0e735307422, createdName=YS出品, createdTime=Mon Sep 28 13:26:38 CST 2020, time=2020-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1402401, encodeId=c4a31402401ae, content=<a href='/topic/show?id=862e8e196a1' target=_blank style='color:#2F92EE;'>#茶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87196, encryptionId=862e8e196a1, topicName=茶)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/eTyQ1TyLVfyaGrflWSd1Jw4u1F68ibicmN32DE38FjEW3zTIKeFeaMUAQsjyqaL4QZ3lRibFIzziacMz9niceznOTTw/132, createdBy=03082405249, createdName=hbwxf, createdTime=Fri Sep 25 07:00:55 CST 2020, time=2020-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1412643, encodeId=ecab1412643de, content=<a href='/topic/show?id=32ec89220b' target=_blank style='color:#2F92EE;'>#HIV病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8922, encryptionId=32ec89220b, topicName=HIV病毒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fa102876871, createdName=tigerlr99, createdTime=Fri Sep 25 07:00:55 CST 2020, time=2020-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512367, encodeId=ea78151236eca, content=<a href='/topic/show?id=6a15e09150c' target=_blank style='color:#2F92EE;'>#病毒复制#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70915, encryptionId=6a15e09150c, topicName=病毒复制)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1a2310462124, createdName=12498623m96暂无昵称, createdTime=Fri Sep 25 07:00:55 CST 2020, time=2020-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1538596, encodeId=8ed415385969b, content=<a href='/topic/show?id=751e42660f1' target=_blank style='color:#2F92EE;'>#复旦#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42660, encryptionId=751e42660f1, topicName=复旦)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6c312994908, createdName=saikp, createdTime=Fri Sep 25 07:00:55 CST 2020, time=2020-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887880, encodeId=a05f88e8804e, content=嘿嘿、我喜欢喝茶, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220301/6252e946e5ef413b86dc0f7d1f73b6db/9a7e8c88a38e487b8da4968a67bbd261.png, createdBy=b9f692910, createdName=rayms, createdTime=Thu Sep 24 10:19:05 CST 2020, time=2020-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887877, encodeId=a78488e877b7, content=这也可以吗?努力吧<a href='/topic/show?id=aa0582e6946' target=_blank style='color:#2F92EE;'>#肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=167, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82769, encryptionId=aa0582e6946, topicName=肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0d4d2326628, createdName=1225f870m98(暂无昵称), createdTime=Thu Sep 24 10:10:14 CST 2020, time=2020-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887841, encodeId=2a3c88e841df, content=不是很靠谱, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200923/1127ba78eea04b1881bce424b58205b4/4bd4943b16264509a3ef9068dfa83150.jpg, createdBy=f73c5420857, createdName=ms3000000222172370, createdTime=Thu Sep 24 08:48:30 CST 2020, time=2020-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887774, encodeId=0a2c88e7744d, content=还是好好吃饭,提高自己的自身免疫力最靠谱!, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Wed Sep 23 21:31:40 CST 2020, time=2020-09-23, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=905575, encodeId=78929055e5ae, content=太给力了, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e26b5442082, createdName=ms9000001141432276, createdTime=Mon Dec 07 01:22:37 CST 2020, time=2020-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=888894, encodeId=002e8888947e, content=牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eohaPibNmxiaAxe7H2PbNMiaAThPR6wVlN52bo7M6QPFLzto3RvuJvzaVRUKLSWhiaibjsTImrk9BOkM9Q/132, createdBy=0e735307422, createdName=YS出品, createdTime=Mon Sep 28 13:26:38 CST 2020, time=2020-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1402401, encodeId=c4a31402401ae, content=<a href='/topic/show?id=862e8e196a1' target=_blank style='color:#2F92EE;'>#茶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87196, encryptionId=862e8e196a1, topicName=茶)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/eTyQ1TyLVfyaGrflWSd1Jw4u1F68ibicmN32DE38FjEW3zTIKeFeaMUAQsjyqaL4QZ3lRibFIzziacMz9niceznOTTw/132, createdBy=03082405249, createdName=hbwxf, createdTime=Fri Sep 25 07:00:55 CST 2020, time=2020-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1412643, encodeId=ecab1412643de, content=<a href='/topic/show?id=32ec89220b' target=_blank style='color:#2F92EE;'>#HIV病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8922, encryptionId=32ec89220b, topicName=HIV病毒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fa102876871, createdName=tigerlr99, createdTime=Fri Sep 25 07:00:55 CST 2020, time=2020-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512367, encodeId=ea78151236eca, content=<a href='/topic/show?id=6a15e09150c' target=_blank style='color:#2F92EE;'>#病毒复制#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70915, encryptionId=6a15e09150c, topicName=病毒复制)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1a2310462124, createdName=12498623m96暂无昵称, createdTime=Fri Sep 25 07:00:55 CST 2020, time=2020-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1538596, encodeId=8ed415385969b, content=<a href='/topic/show?id=751e42660f1' target=_blank style='color:#2F92EE;'>#复旦#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42660, encryptionId=751e42660f1, topicName=复旦)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6c312994908, createdName=saikp, createdTime=Fri Sep 25 07:00:55 CST 2020, time=2020-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887880, encodeId=a05f88e8804e, content=嘿嘿、我喜欢喝茶, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220301/6252e946e5ef413b86dc0f7d1f73b6db/9a7e8c88a38e487b8da4968a67bbd261.png, createdBy=b9f692910, createdName=rayms, createdTime=Thu Sep 24 10:19:05 CST 2020, time=2020-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887877, encodeId=a78488e877b7, content=这也可以吗?努力吧<a href='/topic/show?id=aa0582e6946' target=_blank style='color:#2F92EE;'>#肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=167, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82769, encryptionId=aa0582e6946, topicName=肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0d4d2326628, createdName=1225f870m98(暂无昵称), createdTime=Thu Sep 24 10:10:14 CST 2020, time=2020-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887841, encodeId=2a3c88e841df, content=不是很靠谱, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200923/1127ba78eea04b1881bce424b58205b4/4bd4943b16264509a3ef9068dfa83150.jpg, createdBy=f73c5420857, createdName=ms3000000222172370, createdTime=Thu Sep 24 08:48:30 CST 2020, time=2020-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887774, encodeId=0a2c88e7744d, content=还是好好吃饭,提高自己的自身免疫力最靠谱!, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Wed Sep 23 21:31:40 CST 2020, time=2020-09-23, status=1, ipAttribution=)]
    2020-09-25 saikp
  7. [GetPortalCommentsPageByObjectIdResponse(id=905575, encodeId=78929055e5ae, content=太给力了, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e26b5442082, createdName=ms9000001141432276, createdTime=Mon Dec 07 01:22:37 CST 2020, time=2020-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=888894, encodeId=002e8888947e, content=牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eohaPibNmxiaAxe7H2PbNMiaAThPR6wVlN52bo7M6QPFLzto3RvuJvzaVRUKLSWhiaibjsTImrk9BOkM9Q/132, createdBy=0e735307422, createdName=YS出品, createdTime=Mon Sep 28 13:26:38 CST 2020, time=2020-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1402401, encodeId=c4a31402401ae, content=<a href='/topic/show?id=862e8e196a1' target=_blank style='color:#2F92EE;'>#茶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87196, encryptionId=862e8e196a1, topicName=茶)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/eTyQ1TyLVfyaGrflWSd1Jw4u1F68ibicmN32DE38FjEW3zTIKeFeaMUAQsjyqaL4QZ3lRibFIzziacMz9niceznOTTw/132, createdBy=03082405249, createdName=hbwxf, createdTime=Fri Sep 25 07:00:55 CST 2020, time=2020-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1412643, encodeId=ecab1412643de, content=<a href='/topic/show?id=32ec89220b' target=_blank style='color:#2F92EE;'>#HIV病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8922, encryptionId=32ec89220b, topicName=HIV病毒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fa102876871, createdName=tigerlr99, createdTime=Fri Sep 25 07:00:55 CST 2020, time=2020-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512367, encodeId=ea78151236eca, content=<a href='/topic/show?id=6a15e09150c' target=_blank style='color:#2F92EE;'>#病毒复制#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70915, encryptionId=6a15e09150c, topicName=病毒复制)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1a2310462124, createdName=12498623m96暂无昵称, createdTime=Fri Sep 25 07:00:55 CST 2020, time=2020-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1538596, encodeId=8ed415385969b, content=<a href='/topic/show?id=751e42660f1' target=_blank style='color:#2F92EE;'>#复旦#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42660, encryptionId=751e42660f1, topicName=复旦)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6c312994908, createdName=saikp, createdTime=Fri Sep 25 07:00:55 CST 2020, time=2020-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887880, encodeId=a05f88e8804e, content=嘿嘿、我喜欢喝茶, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220301/6252e946e5ef413b86dc0f7d1f73b6db/9a7e8c88a38e487b8da4968a67bbd261.png, createdBy=b9f692910, createdName=rayms, createdTime=Thu Sep 24 10:19:05 CST 2020, time=2020-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887877, encodeId=a78488e877b7, content=这也可以吗?努力吧<a href='/topic/show?id=aa0582e6946' target=_blank style='color:#2F92EE;'>#肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=167, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82769, encryptionId=aa0582e6946, topicName=肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0d4d2326628, createdName=1225f870m98(暂无昵称), createdTime=Thu Sep 24 10:10:14 CST 2020, time=2020-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887841, encodeId=2a3c88e841df, content=不是很靠谱, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200923/1127ba78eea04b1881bce424b58205b4/4bd4943b16264509a3ef9068dfa83150.jpg, createdBy=f73c5420857, createdName=ms3000000222172370, createdTime=Thu Sep 24 08:48:30 CST 2020, time=2020-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887774, encodeId=0a2c88e7744d, content=还是好好吃饭,提高自己的自身免疫力最靠谱!, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Wed Sep 23 21:31:40 CST 2020, time=2020-09-23, status=1, ipAttribution=)]
    2020-09-24 rayms

    嘿嘿、我喜欢喝茶

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=905575, encodeId=78929055e5ae, content=太给力了, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e26b5442082, createdName=ms9000001141432276, createdTime=Mon Dec 07 01:22:37 CST 2020, time=2020-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=888894, encodeId=002e8888947e, content=牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eohaPibNmxiaAxe7H2PbNMiaAThPR6wVlN52bo7M6QPFLzto3RvuJvzaVRUKLSWhiaibjsTImrk9BOkM9Q/132, createdBy=0e735307422, createdName=YS出品, createdTime=Mon Sep 28 13:26:38 CST 2020, time=2020-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1402401, encodeId=c4a31402401ae, content=<a href='/topic/show?id=862e8e196a1' target=_blank style='color:#2F92EE;'>#茶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87196, encryptionId=862e8e196a1, topicName=茶)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/eTyQ1TyLVfyaGrflWSd1Jw4u1F68ibicmN32DE38FjEW3zTIKeFeaMUAQsjyqaL4QZ3lRibFIzziacMz9niceznOTTw/132, createdBy=03082405249, createdName=hbwxf, createdTime=Fri Sep 25 07:00:55 CST 2020, time=2020-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1412643, encodeId=ecab1412643de, content=<a href='/topic/show?id=32ec89220b' target=_blank style='color:#2F92EE;'>#HIV病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8922, encryptionId=32ec89220b, topicName=HIV病毒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fa102876871, createdName=tigerlr99, createdTime=Fri Sep 25 07:00:55 CST 2020, time=2020-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512367, encodeId=ea78151236eca, content=<a href='/topic/show?id=6a15e09150c' target=_blank style='color:#2F92EE;'>#病毒复制#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70915, encryptionId=6a15e09150c, topicName=病毒复制)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1a2310462124, createdName=12498623m96暂无昵称, createdTime=Fri Sep 25 07:00:55 CST 2020, time=2020-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1538596, encodeId=8ed415385969b, content=<a href='/topic/show?id=751e42660f1' target=_blank style='color:#2F92EE;'>#复旦#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42660, encryptionId=751e42660f1, topicName=复旦)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6c312994908, createdName=saikp, createdTime=Fri Sep 25 07:00:55 CST 2020, time=2020-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887880, encodeId=a05f88e8804e, content=嘿嘿、我喜欢喝茶, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220301/6252e946e5ef413b86dc0f7d1f73b6db/9a7e8c88a38e487b8da4968a67bbd261.png, createdBy=b9f692910, createdName=rayms, createdTime=Thu Sep 24 10:19:05 CST 2020, time=2020-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887877, encodeId=a78488e877b7, content=这也可以吗?努力吧<a href='/topic/show?id=aa0582e6946' target=_blank style='color:#2F92EE;'>#肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=167, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82769, encryptionId=aa0582e6946, topicName=肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0d4d2326628, createdName=1225f870m98(暂无昵称), createdTime=Thu Sep 24 10:10:14 CST 2020, time=2020-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887841, encodeId=2a3c88e841df, content=不是很靠谱, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200923/1127ba78eea04b1881bce424b58205b4/4bd4943b16264509a3ef9068dfa83150.jpg, createdBy=f73c5420857, createdName=ms3000000222172370, createdTime=Thu Sep 24 08:48:30 CST 2020, time=2020-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887774, encodeId=0a2c88e7744d, content=还是好好吃饭,提高自己的自身免疫力最靠谱!, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Wed Sep 23 21:31:40 CST 2020, time=2020-09-23, status=1, ipAttribution=)]
    2020-09-24 1225f870m98(暂无昵称)

    这也可以吗?努力吧#肿瘤#

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=905575, encodeId=78929055e5ae, content=太给力了, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e26b5442082, createdName=ms9000001141432276, createdTime=Mon Dec 07 01:22:37 CST 2020, time=2020-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=888894, encodeId=002e8888947e, content=牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eohaPibNmxiaAxe7H2PbNMiaAThPR6wVlN52bo7M6QPFLzto3RvuJvzaVRUKLSWhiaibjsTImrk9BOkM9Q/132, createdBy=0e735307422, createdName=YS出品, createdTime=Mon Sep 28 13:26:38 CST 2020, time=2020-09-28, status=1, ipAttribution=), 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encryptionId=32ec89220b, topicName=HIV病毒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fa102876871, createdName=tigerlr99, createdTime=Fri Sep 25 07:00:55 CST 2020, time=2020-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512367, encodeId=ea78151236eca, content=<a href='/topic/show?id=6a15e09150c' target=_blank style='color:#2F92EE;'>#病毒复制#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70915, encryptionId=6a15e09150c, topicName=病毒复制)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1a2310462124, createdName=12498623m96暂无昵称, createdTime=Fri Sep 25 07:00:55 CST 2020, time=2020-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1538596, encodeId=8ed415385969b, content=<a href='/topic/show?id=751e42660f1' target=_blank style='color:#2F92EE;'>#复旦#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42660, encryptionId=751e42660f1, topicName=复旦)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6c312994908, createdName=saikp, createdTime=Fri Sep 25 07:00:55 CST 2020, time=2020-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887880, encodeId=a05f88e8804e, content=嘿嘿、我喜欢喝茶, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220301/6252e946e5ef413b86dc0f7d1f73b6db/9a7e8c88a38e487b8da4968a67bbd261.png, createdBy=b9f692910, createdName=rayms, createdTime=Thu Sep 24 10:19:05 CST 2020, time=2020-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887877, encodeId=a78488e877b7, content=这也可以吗?努力吧<a href='/topic/show?id=aa0582e6946' target=_blank style='color:#2F92EE;'>#肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=167, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82769, encryptionId=aa0582e6946, topicName=肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0d4d2326628, createdName=1225f870m98(暂无昵称), createdTime=Thu Sep 24 10:10:14 CST 2020, time=2020-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887841, encodeId=2a3c88e841df, content=不是很靠谱, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200923/1127ba78eea04b1881bce424b58205b4/4bd4943b16264509a3ef9068dfa83150.jpg, createdBy=f73c5420857, createdName=ms3000000222172370, createdTime=Thu Sep 24 08:48:30 CST 2020, time=2020-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887774, encodeId=0a2c88e7744d, content=还是好好吃饭,提高自己的自身免疫力最靠谱!, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Wed Sep 23 21:31:40 CST 2020, time=2020-09-23, status=1, ipAttribution=)]
    2020-09-24 ms3000000222172370

    不是很靠谱

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=905575, encodeId=78929055e5ae, content=太给力了, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e26b5442082, createdName=ms9000001141432276, createdTime=Mon Dec 07 01:22:37 CST 2020, time=2020-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=888894, encodeId=002e8888947e, content=牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eohaPibNmxiaAxe7H2PbNMiaAThPR6wVlN52bo7M6QPFLzto3RvuJvzaVRUKLSWhiaibjsTImrk9BOkM9Q/132, createdBy=0e735307422, createdName=YS出品, createdTime=Mon Sep 28 13:26:38 CST 2020, time=2020-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1402401, encodeId=c4a31402401ae, content=<a href='/topic/show?id=862e8e196a1' target=_blank style='color:#2F92EE;'>#茶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87196, encryptionId=862e8e196a1, topicName=茶)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/eTyQ1TyLVfyaGrflWSd1Jw4u1F68ibicmN32DE38FjEW3zTIKeFeaMUAQsjyqaL4QZ3lRibFIzziacMz9niceznOTTw/132, createdBy=03082405249, createdName=hbwxf, createdTime=Fri Sep 25 07:00:55 CST 2020, time=2020-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1412643, encodeId=ecab1412643de, content=<a href='/topic/show?id=32ec89220b' target=_blank style='color:#2F92EE;'>#HIV病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8922, encryptionId=32ec89220b, topicName=HIV病毒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fa102876871, createdName=tigerlr99, createdTime=Fri Sep 25 07:00:55 CST 2020, time=2020-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512367, encodeId=ea78151236eca, content=<a href='/topic/show?id=6a15e09150c' target=_blank style='color:#2F92EE;'>#病毒复制#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70915, encryptionId=6a15e09150c, topicName=病毒复制)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1a2310462124, createdName=12498623m96暂无昵称, createdTime=Fri Sep 25 07:00:55 CST 2020, time=2020-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1538596, encodeId=8ed415385969b, content=<a href='/topic/show?id=751e42660f1' target=_blank style='color:#2F92EE;'>#复旦#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42660, encryptionId=751e42660f1, topicName=复旦)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6c312994908, createdName=saikp, createdTime=Fri Sep 25 07:00:55 CST 2020, time=2020-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887880, encodeId=a05f88e8804e, content=嘿嘿、我喜欢喝茶, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220301/6252e946e5ef413b86dc0f7d1f73b6db/9a7e8c88a38e487b8da4968a67bbd261.png, createdBy=b9f692910, createdName=rayms, createdTime=Thu Sep 24 10:19:05 CST 2020, time=2020-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887877, encodeId=a78488e877b7, content=这也可以吗?努力吧<a href='/topic/show?id=aa0582e6946' target=_blank style='color:#2F92EE;'>#肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=167, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82769, encryptionId=aa0582e6946, topicName=肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0d4d2326628, createdName=1225f870m98(暂无昵称), createdTime=Thu Sep 24 10:10:14 CST 2020, time=2020-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887841, encodeId=2a3c88e841df, content=不是很靠谱, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200923/1127ba78eea04b1881bce424b58205b4/4bd4943b16264509a3ef9068dfa83150.jpg, createdBy=f73c5420857, createdName=ms3000000222172370, createdTime=Thu Sep 24 08:48:30 CST 2020, time=2020-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887774, encodeId=0a2c88e7744d, content=还是好好吃饭,提高自己的自身免疫力最靠谱!, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Wed Sep 23 21:31:40 CST 2020, time=2020-09-23, status=1, ipAttribution=)]
    2020-09-23 Jessica

    还是好好吃饭,提高自己的自身免疫力最靠谱!

    0

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