Ann Intern Med:麻疹、腮腺炎、风疹疫苗接种与自闭症

2019-03-06 xing.T 网络

由此可见,该研究强烈支持MMR疫苗接种不会增加自闭症的风险,不会引发易感儿童的自闭症,并且与接种疫苗后自闭症病例的聚集无关。

麻疹、腮腺炎、风疹(MMR)疫苗与自闭症之间的可能联系持续引起关注,并挑战疫苗接种的意义。近日,内科学权威杂志Annals of Internal Medicine上发表了一篇研究文章,研究人员旨在评估MMR疫苗是否会增加儿童儿童亚组或接种疫苗后自闭症的风险。

该研究为丹麦全国范围内进行的队列研究,参与者为1999年至2010年12月31日期间在丹麦出生的657461名儿童,其随访从1岁开始至2013年8月31日。丹麦人口登记处被用于将MMR疫苗接种、自闭症诊断、其他儿童疫苗、兄弟姐妹自闭症史和自闭症风险因素的信息与该队列中的儿童联系起来。研究人员使用Cox比例风险回归评估自闭症诊断时间的生存分析用于根据MMR疫苗接种状态来估计自闭症的风险比,并调整年龄、出生年份、性别、其他儿童疫苗、兄弟姐妹自闭症史和自闭症危险因素(根据疾病风险评分)。

在5025754人次每年的随访期间,6517名儿童被诊断患有自闭症(发病率为129.7人/10万人每年)。将MMR接种儿童与MMR未接种儿童进行比较得到完全调整后的自闭症风险比为0.93(95%CI为0.85至1.02)。同样,在根据兄弟姐妹自闭症史、自闭症危险因素(基于疾病风险评分)或其他儿童接种疫苗定义的儿童亚组中,或在接种疫苗后的特定时间段内,始终观察到MMR疫苗接种后自闭症的风险没有增加。

由此可见,该研究强烈支持MMR疫苗接种不会增加自闭症的风险,不会引发易感儿童的自闭症,并且与接种疫苗后自闭症病例的聚集无关。

原始出处:

Anders Hviid,et al.Measles, Mumps, Rubella Vaccination and Autism: A Nationwide Cohort Study FREE.AIM.2019.https://annals.org/aim/fullarticle/2727726/measles-mumps-rubella-vaccination-autism-nationwide-cohort-study

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    2019-03-08 zhaojie88
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    2019-03-08 mfx799
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    2019-03-08 xiongke014
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    2019-03-08 sunyl14

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