Heart:慢性肾病患者房颤与肾功能下降之间的关联

2021-07-13 MedSci原创 MedSci原创

在CKD患者中,AF与随后较大的肾功能下降风险相关。CHA2DS2-VASc评分可能是一种有用的风险分层手段,可用于预测肾功能下降的风险。

已知慢性肾脏病(CKD)会增加房颤(AF)的风险,但AF与CKD患者随后肾功能下降之间的关系尚未明确。

近日,心脏病领域权威杂志Heart上发表了一篇研究文章,在这项研究中,研究人员旨在探究AF对CKD患者肾脏结局的影响。

在这项基于医院的回顾性队列研究中,研究人员确定了2008年1月1日至2018年12月31日期间年龄20岁以上的CKD患者。受试者分为AF组和非AF组。研究人员根据倾向评分将每位伴有AF的CKD患者与两名非AF的CKD对照者进行匹配。感兴趣的结局包括估计肾小球滤过率(eGFR)下降≥20%、≥30%、≥40%和≥50%,以及终末期肾病(ESRD)。

生存曲线

倾向评分匹配后,6731名AF患者以及13462名匹配的对照者被纳入研究。与非AF组相比,AF组eGFR下降≥20%(HR为1.43;95%CI为1.33至1.53)、≥30%(HR为1.50;95%CI为1.36至1.66)、≥40%(HR为1.62;95%CI为1.41到1.85)和≥50%(HR为1.82;95%CI为1.50到2.20)和ESRD(HR为1.22;95%CI为1.12到1.34)的风险更大。较高的CHA2DS2-VASc评分与eGFR下降和ESRD的风险较大相关。

由此可见,在CKD患者中,AF与随后较大的肾功能下降风险相关。CHA2DS2-VASc评分可能是一种有用的风险分层手段,可用于预测肾功能下降的风险

原始出处:

Heng Chen.et al.Associations of atrial fibrillation with renal function decline in patients with chronic kidney disease.heart.2021.https://heart.bmj.com/content/early/2021/06/29/heartjnl-2021-319297

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    2021-07-25 yese
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    2021-07-15 zhaojie88
  5. [GetPortalCommentsPageByObjectIdResponse(id=2025904, encodeId=21e42025904ef, content=<a href='/topic/show?id=a91d82583bf' target=_blank style='color:#2F92EE;'>#肾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82583, encryptionId=a91d82583bf, topicName=肾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=db5b227, createdName=gostraight, createdTime=Thu Oct 07 15:03:10 CST 2021, time=2021-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2055988, encodeId=d7aa2055988d8, content=<a href='/topic/show?id=d088536467a' target=_blank style='color:#2F92EE;'>#慢性肾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53646, encryptionId=d088536467a, topicName=慢性肾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=568152, createdName=snowpeakxu, createdTime=Thu May 12 23:03:10 CST 2022, time=2022-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1850792, encodeId=fc0e1850e9276, content=<a href='/topic/show?id=46c682469e4' target=_blank style='color:#2F92EE;'>#肾功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82469, encryptionId=46c682469e4, topicName=肾功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28d456, createdName=yese, createdTime=Sun Jul 25 11:03:10 CST 2021, time=2021-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357741, encodeId=eb06135e741d9, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Jul 15 14:03:10 CST 2021, time=2021-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1537220, encodeId=c9e5153e22056, content=<a href='/topic/show?id=fc66824e015' target=_blank style='color:#2F92EE;'>#肾功能下降#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82470, encryptionId=fc66824e015, topicName=肾功能下降)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ceb912833334, createdName=syscxl, createdTime=Thu Jul 15 14:03:10 CST 2021, time=2021-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563490, encodeId=2e3a156349089, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Thu Jul 15 14:03:10 CST 2021, time=2021-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031423, encodeId=1854103142392, content=房颤,临床上碰到很多哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=心介, createdTime=Wed Jul 14 02:03:10 CST 2021, time=2021-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=999243, encodeId=16e2999243df, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d92e4883236, createdName=1540405170, createdTime=Tue Jul 13 23:06:40 CST 2021, time=2021-07-13, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=2025904, encodeId=21e42025904ef, content=<a href='/topic/show?id=a91d82583bf' target=_blank style='color:#2F92EE;'>#肾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82583, encryptionId=a91d82583bf, topicName=肾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=db5b227, createdName=gostraight, createdTime=Thu Oct 07 15:03:10 CST 2021, time=2021-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2055988, encodeId=d7aa2055988d8, content=<a href='/topic/show?id=d088536467a' target=_blank style='color:#2F92EE;'>#慢性肾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53646, encryptionId=d088536467a, topicName=慢性肾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=568152, createdName=snowpeakxu, createdTime=Thu May 12 23:03:10 CST 2022, time=2022-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1850792, encodeId=fc0e1850e9276, content=<a href='/topic/show?id=46c682469e4' target=_blank style='color:#2F92EE;'>#肾功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82469, encryptionId=46c682469e4, topicName=肾功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28d456, createdName=yese, createdTime=Sun Jul 25 11:03:10 CST 2021, time=2021-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357741, encodeId=eb06135e741d9, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Jul 15 14:03:10 CST 2021, time=2021-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1537220, encodeId=c9e5153e22056, content=<a href='/topic/show?id=fc66824e015' target=_blank style='color:#2F92EE;'>#肾功能下降#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82470, encryptionId=fc66824e015, topicName=肾功能下降)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ceb912833334, createdName=syscxl, createdTime=Thu Jul 15 14:03:10 CST 2021, time=2021-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563490, encodeId=2e3a156349089, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Thu Jul 15 14:03:10 CST 2021, time=2021-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031423, encodeId=1854103142392, content=房颤,临床上碰到很多哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=心介, createdTime=Wed Jul 14 02:03:10 CST 2021, time=2021-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=999243, encodeId=16e2999243df, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d92e4883236, createdName=1540405170, createdTime=Tue Jul 13 23:06:40 CST 2021, time=2021-07-13, status=1, ipAttribution=)]
    2021-07-15 slcumt
  7. [GetPortalCommentsPageByObjectIdResponse(id=2025904, encodeId=21e42025904ef, content=<a href='/topic/show?id=a91d82583bf' target=_blank style='color:#2F92EE;'>#肾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82583, encryptionId=a91d82583bf, topicName=肾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=db5b227, createdName=gostraight, createdTime=Thu Oct 07 15:03:10 CST 2021, time=2021-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2055988, encodeId=d7aa2055988d8, content=<a href='/topic/show?id=d088536467a' target=_blank style='color:#2F92EE;'>#慢性肾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53646, encryptionId=d088536467a, topicName=慢性肾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=568152, createdName=snowpeakxu, createdTime=Thu May 12 23:03:10 CST 2022, time=2022-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1850792, encodeId=fc0e1850e9276, content=<a href='/topic/show?id=46c682469e4' target=_blank style='color:#2F92EE;'>#肾功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82469, encryptionId=46c682469e4, topicName=肾功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28d456, createdName=yese, createdTime=Sun Jul 25 11:03:10 CST 2021, time=2021-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357741, encodeId=eb06135e741d9, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Jul 15 14:03:10 CST 2021, time=2021-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1537220, encodeId=c9e5153e22056, content=<a href='/topic/show?id=fc66824e015' target=_blank style='color:#2F92EE;'>#肾功能下降#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82470, encryptionId=fc66824e015, topicName=肾功能下降)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ceb912833334, createdName=syscxl, createdTime=Thu Jul 15 14:03:10 CST 2021, time=2021-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563490, encodeId=2e3a156349089, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Thu Jul 15 14:03:10 CST 2021, time=2021-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031423, encodeId=1854103142392, content=房颤,临床上碰到很多哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=心介, createdTime=Wed Jul 14 02:03:10 CST 2021, time=2021-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=999243, encodeId=16e2999243df, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d92e4883236, createdName=1540405170, createdTime=Tue Jul 13 23:06:40 CST 2021, time=2021-07-13, status=1, ipAttribution=)]
    2021-07-14 心介

    房颤,临床上碰到很多哦

    0

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    2021-07-13 1540405170

    学习了

    0

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专家访谈|荆志成:全学科范围积极推广左心耳封堵术,实现高卒中风险房颤患者远离卒中

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