J Rheumatol:类风湿性关节炎患者的关节置换手术趋势

2017-12-11 xiangting MedSci原创

TSA和TEA患者中RA的患病率有所下降。TAA患者中没有显著下降。

这项研究分析了大型全关节置换术(TJA)的趋势以及这些手术在类风湿性关节炎(RA)患者中进行的比例。

采用美国全国住院样本(2002 - 2012年)来分析全肩关节(TSA),肘关节(TEA),膝关节(TKA),髋关节(THA)和踝关节(TAA)关节置换术的发生率,及其在RA患者中实施的比例。

TJA患者中RA的患病率增加3.0%。TEA和TSA病例中RA的患病率分别下降50%(p <0.0001)和18%(p = 0.0016); TAA中RA的患病率降低38.0%(p = 0.06); 在THA和TKA中没有显著增加。接受TJA治疗的RA患者与非RA患者的平均年龄差异缩小2年(p <0.0001)。女性RA患者比男性RA患者TSA、TEA和TAA组的比例下降更多。在TSA和TEA组中,白种人RA患者的比例有所下降,而不是黑人。自费的TSA和TAA RA患者比例下降,而接受医疗补助(政府医疗保险)进行TSA、TEA或TAA的RA患者保持相对稳定。

TSA和TEA患者中RA的患病率有所下降。TAA患者中没有显著下降。接受TJA的RA患者平均年龄正在开始接近无RA患者。TSA、TEA和TAA患者的性别比例也遵循类似的模式。这些结果可能是现代RA治疗策略成功的证据。

原始出处:
Bradley L. Young, et al. Trends in Joint Replacement Surgery in Patients with Rheumatoid Arthritis.  J Rheumatol. 1 December 2017. 

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    2018-09-01 yxch48
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    2017-12-13 lmm397
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1742454, encodeId=ac7b1e4245442, content=<a href='/topic/show?id=39cae96626f' target=_blank style='color:#2F92EE;'>#置换#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79662, encryptionId=39cae96626f, topicName=置换)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3a7c35056336, createdName=yxch48, createdTime=Sat Sep 01 08:34:00 CST 2018, time=2018-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1265595, encodeId=cba31265595a5, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Wed Dec 13 06:34:00 CST 2017, time=2017-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1333959, encodeId=7543133395974, content=<a href='/topic/show?id=5306e6164b6' target=_blank style='color:#2F92EE;'>#类风湿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76164, encryptionId=5306e6164b6, topicName=类风湿)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Wed Dec 13 06:34:00 CST 2017, time=2017-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483455, encodeId=ef841483455de, content=<a href='/topic/show?id=55a6100826cc' target=_blank style='color:#2F92EE;'>#风湿性关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100826, encryptionId=55a6100826cc, topicName=风湿性关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c237911872, createdName=ms1467340776200723, createdTime=Wed Dec 13 06:34:00 CST 2017, time=2017-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268647, encodeId=dfe326864efa, content=这项研究分析了大型全关节置换术(TJA)的趋势以及这些手术在类风湿性关节炎(RA)患者中进行的比例., beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Mon Dec 11 17:12:18 CST 2017, time=2017-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268627, encodeId=f5b226862ea7, content=学习学习.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Mon Dec 11 15:43:35 CST 2017, time=2017-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268623, encodeId=bf4d26862385, content=不错,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48ce1618316, createdName=stupidox, createdTime=Mon Dec 11 15:42:26 CST 2017, time=2017-12-11, status=1, ipAttribution=)]
    2017-12-11 有备才能无患

    这项研究分析了大型全关节置换术(TJA)的趋势以及这些手术在类风湿性关节炎(RA)患者中进行的比例.

    0

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    2017-12-11 1dd8c52fm63(暂无匿称)

    学习学习.继续关注

    0

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    2017-12-11 stupidox

    不错,学习了。

    0

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本研究旨在探究牙周炎是否出现在RA症状出现之前。此外,我们分析了与对照组相比,在症状前个体中核因子κ-B(RANKL)(一种对骨吸收重要的细胞因子)和抗瓜氨酸肽抗体(ACPA)的受体激活剂的血浆水平。 通过前磨牙/磨牙区域的颌骨X线片测量了176名受试者(其中93名已经发展为RA)的边缘颌骨水平。其中46人记录了症状发作前的X线片,性别、年龄和吸烟状态指标相匹配的有45个。使用ELISA分析血浆R

J Rheumatol:类风湿性关节炎中抗体与含高瓜氨酸或瓜氨酸肽的相关性

RA患者常有CitJED和HomoCitJED抗体,但在SLE或PsA中未发现这些抗体,提示这些抗体是RA特异性的。

Ann Rheum Dis:来氟米特在怀孕期间的使用和不良妊娠结局的风险

妊娠期间母体来氟米特暴露与MCMs、早产、LBW或自然流产的风险显著升高无相关性。

Ann Rheum Dis:使用生物性DMARDs治疗的类风湿性关节炎患者继发性恶性肿瘤和死亡的风险

对于有癌症病史的RA患者,bDMARDs治疗与SMN风险升高无关。