J Gastroenterology:单采血液分离术对溃疡性结肠炎患者的维持治疗效果

2020-04-04 MedSci原创 MedSci原创

血浆置换分离疗法包括选择性地清除白细胞疗法,可以用于诱导溃疡性结肠炎(UC)患者的缓解治疗。本研究的目的是为了证明血浆置换疗法对维持UC缓解的疗效和安全性。

背景及目的:血浆置换分离疗法包括选择性地清除白细胞疗法,可以用于诱导溃疡性结肠炎(UC)患者的缓解治疗。本研究的目的是为了证明血浆置换疗法对维持UC缓解的疗效和安全性。

研究方法:研究人员进行了一项多中心、前瞻性、随机对照试验,研究了粒细胞和单核细胞吸附置换术或白细胞置换术诱导的缓解型UC患者的疗效。所有患者按1:1的分配比例被随机分配到采血治疗组(每月两次,为期12个月)或对照组(无采血治疗)。主要终点是12个月时的累计临床缓解率(梅奥评分≤2)。次要终点是12个月时的临床缓解率、内镜下缓解率和完全内镜下缓解率。

研究结果:2013年3月至2017年3月的时间里共有164名患者入组。12个月时的累计缓解率为:采血置换组46.6%,对照组36.4%(P = 0.1621)。12个月时的内镜下缓解率明显高于对照组(42.5% vs. 25.9%)P = 0.0480。采血置换组的临床缓解率(47.5% vs.32.1%,P = 0.0540)和内镜下完全缓解率(33.8% vs.19.8%,P = 0.0513)高于对照组;然而,差异不显着。两组中均未观察到严重不良事件。

研究结论:尽管在12个月时的累计临床缓解率与对照组之间疗效相差无几,但血浆置换治疗作为UC的维持性治疗其耐受性良好。

原始出处:

Makoto Naganuma. Et al. Efficacy of apheresis as maintenance therapy for patients with ulcerative colitis in an open-label prospective multicenter randomised controlled trial. J Gastroenterology.2020.

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    2020-07-06 许安
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    2020-09-11 nymo
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    2020-04-05 内科新手

    谢谢梅斯提供这么好的信息,学到很多

    0

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    2020-04-05 CHANGE

    疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的

    0

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