Int J Impot Res:米拉贝隆改善膀胱过度活动症和勃起功能障碍男性的勃起功能

2021-07-06 AlexYang MedSci原创

勃起功能障碍(ED)定义为 "男性无法实现和/或维持足以满足性行为的勃起",该障碍影响到数百万男性,且全球流行率不断上升。由于磷酸二酯酶5型抑制剂 (PDE5i)具有良好的临床疗效和安全性,通常被临床

勃起功能障碍(ED)定义为 "男性无法实现和/或维持足以满足性行为的勃起",该障碍影响到数百万男性,且全球流行率不断上升。由于磷酸二酯酶5型抑制剂 (PDE5i)具有良好的临床疗效和安全性,通常被临床医生推荐为一线疗法。PDE5i对男性ED患者成功进行性交的有效性约65%,而对糖尿病和盆腔术后的男性效果较差。

磷酸二酯酶5型抑制剂(PDE5i)是美国唯一批准的勃起功能障碍(ED)的口服治疗方法,当这种治疗方法失败或禁忌时,仍有必要采取替代性方法。靶向NO-cGMP途径以外的其他途径和/或将这种方法与PDE5i相结合,可能会为那些对PDE5i没有反应的男性引入新的治疗方法。

近期,有研究人员评估了米拉贝隆(Mirabegron)是否能改善同时患有膀胱过度活动症和轻度至中度ED的男性的勃起功能

研究包括了20名受试者,40-70岁,注册国际勃起功能指数(IIEF)得分11-25,国际前列腺症状得分8-20。他们接受了米拉贝隆治疗,为期12周。研究参与者在第2、4、8和12周重新进行IIEF和OAB-q问卷调查,并评估不良事件。主要和次要终点是在研究时间点之间,IIEF-5得分增加4个单位和膀胱过度活动问卷(OAB-q)的症状严重程度得分减少10个单位。共有13名男性完成了为期12周的研究。结果发现,米拉贝隆治疗使5名患者(38.4%)的IIEF-5评分提高了4分或以上,而8名患者(61.5%)的IIEF-5评分则没有受到米拉贝隆治疗的影响。IIEF-5评分没有出现临床相关的下降。与基线相比,在第8周观察到性交满意度有明显改善(P=0.01)。性高潮功能和性欲没有受到米拉贝隆治疗的影响。正如预期,根据OAB-q简表(p=0.006)和OAB-q健康相关生活质量(HRQL)总分,与基线相比,米拉贝隆治疗减少了OAB症状(p=0.03)。残余的膀胱容量没有受到治疗的影响。另外,在研究期间没有报告严重的副作用。

IIEF-5得分变化

综上所述,米拉贝隆可改善某些个体的EF和OAB相关症状,而不会引起严重的不良事件

原始出处:

Serkan Karakus , Biljana Musicki , Arthur L Burnett. Mirabegron improves erectile function in men with overactive bladder and erectile dysfunction: a 12-week pilot study. Int J Impot Res. Jul 2021

 

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    2022-02-20 habb
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    2021-07-08 风铃826

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