Stroke:卒中后谵妄的病程与认知

2021-01-15 MedSci原创 MedSci原创

卒中后谵妄(PSD)是脑卒中和短暂性脑缺血发作的常见并发症。PSD的检测受到诸如局灶性神经功能缺损和至少需要每日筛查等混杂效应的挑战。

卒中后谵妄(PSD)是患者不良预后的独立预测因子。尽管其个体和社会经济负担、发生频率、临床病程和常规检测尚未明确。近日,血管疾病领域权威杂志Stroke上发表了一篇研究文章,这项研究旨在评估已知的谵妄筛查工具的特性,并调查PSD的自然病程。

该研究在3个月内对高危短暂性脑缺血发作或缺血性卒中患者进行了调查。研究人员使用谵妄护理量表和谵妄快速评估法,每天进行两次PSD筛查,并与《精神障碍诊断和统计手册》第五版标准进行非劣效性评价。研究人员调查了人口学和卒中特征作为PSD的预测因素,神经功能障碍作为假阳性筛查结果的预测因素,并进行了模拟研究以估计识别PSD的最佳时间。

研究人员纳入141例患者(73.8±10.4岁,61名女性),美国国立卫生研究院卒中量表平均得分为6.4±6.5。以《精神障碍诊断与统计手册》第五版为基础的PSD发生率为39%,其中25%的病例发生于24小时内,几乎所有病例在72小时内发生。混淆评估方法是唯一不逊于《精神障碍诊断和统计手册》第五版评分的筛查工具,其敏感性为82%,特异性为80%。年龄(比值比为1.07 [1.02-1.13],P=0.004)和美国国立卫生研究院卒中量表(比值比为1.24 [1.15-1.34],P<0.001)是PSD的预测因素。假阳性筛选结果与脑卒中导致的定向障碍(比值比为6.1 [3.2-11.61],P<0.001)和漠视(比值比为2.17 [1.22-3.87],P=0.008)相关。模拟显示,每4个病例就有1个病例被漏掉。

由此可见,PSD是脑卒中和短暂性脑缺血发作的常见并发症。PSD的检测受到诸如局灶性神经功能缺损和至少需要每日筛查等混杂效应的挑战。

原始出处:

Robert Fleischmann.et al.Course and Recognition of Poststroke Delirium A Prospective Noninferiority Trial of Delirium Screening Tools.stroke.2021.https://www.ahajournals.org/doi/10.1161/STROKEAHA.120.031019

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    2021-04-01 ms4000001106117873

    了解到了

    0

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    2021-01-16 145d01efm82暂无昵称

    长知识啦!

    0

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    2021-01-16 ms7000000496107358

    谢谢分享,受益匪浅。

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1671418, encodeId=d9a816e141814, content=<a href='/topic/show?id=9f4e360191a' target=_blank style='color:#2F92EE;'>#卒中后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36019, encryptionId=9f4e360191a, topicName=卒中后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ff7426824786, createdName=waiwai3039, createdTime=Thu May 13 02:26:40 CST 2021, time=2021-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=953136, encodeId=809e953136e0, content=了解到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=38665453234, createdName=ms4000001106117873, createdTime=Thu Apr 01 18:36:23 CST 2021, time=2021-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=917280, encodeId=a92391e280e2, content=长知识啦!, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f355090263, createdName=145d01efm82暂无昵称, createdTime=Sat Jan 16 23:12:32 CST 2021, time=2021-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=917195, encodeId=edc191e19565, content=谢谢分享,受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5c3c5448089, createdName=ms7000000496107358, createdTime=Sat Jan 16 17:56:05 CST 2021, time=2021-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=917098, encodeId=6e1a91e098d1, content=临床是很常见, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201118/644810206ca744f48355b4fc9381cc58/9cfe32903b6a495d8bdfc124267ba3d3.jpg, createdBy=ef782028905, createdName=种鱼的猫猫, createdTime=Sat Jan 16 08:54:47 CST 2021, time=2021-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=917092, encodeId=381691e09288, content=谵妄是老年患者预后不良的预警,不仅限于急性脑卒中。, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Sat Jan 16 08:36:43 CST 2021, time=2021-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=917066, encodeId=214291e066a9, content=<a href='/topic/show?id=e737104148e4' target=_blank style='color:#2F92EE;'>#卒中后谵妄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104148, encryptionId=e737104148e4, topicName=卒中后谵妄)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Sat Jan 16 07:44:54 CST 2021, time=2021-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=917064, encodeId=3a9b91e064d9, content=自然病程,自然转归?, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b7a31928393, createdName=学医无涯, createdTime=Sat Jan 16 07:17:33 CST 2021, time=2021-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026748, encodeId=25211026e4887, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Sat Jan 16 02:26:40 CST 2021, time=2021-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=917041, encodeId=b3c891e04121, content=学习啦, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Sat Jan 16 00:03:32 CST 2021, time=2021-01-16, status=1, ipAttribution=)]
    2021-01-16 种鱼的猫猫

    临床是很常见

    0

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    2021-01-16 yangchou

    谵妄是老年患者预后不良的预警,不仅限于急性脑卒中。

    0

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  8. [GetPortalCommentsPageByObjectIdResponse(id=1671418, encodeId=d9a816e141814, content=<a href='/topic/show?id=9f4e360191a' target=_blank style='color:#2F92EE;'>#卒中后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36019, encryptionId=9f4e360191a, topicName=卒中后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ff7426824786, createdName=waiwai3039, createdTime=Thu May 13 02:26:40 CST 2021, time=2021-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=953136, encodeId=809e953136e0, content=了解到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=38665453234, createdName=ms4000001106117873, createdTime=Thu Apr 01 18:36:23 CST 2021, time=2021-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=917280, encodeId=a92391e280e2, content=长知识啦!, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f355090263, createdName=145d01efm82暂无昵称, createdTime=Sat Jan 16 23:12:32 CST 2021, time=2021-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=917195, encodeId=edc191e19565, content=谢谢分享,受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5c3c5448089, createdName=ms7000000496107358, createdTime=Sat Jan 16 17:56:05 CST 2021, time=2021-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=917098, encodeId=6e1a91e098d1, content=临床是很常见, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201118/644810206ca744f48355b4fc9381cc58/9cfe32903b6a495d8bdfc124267ba3d3.jpg, createdBy=ef782028905, createdName=种鱼的猫猫, createdTime=Sat Jan 16 08:54:47 CST 2021, time=2021-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=917092, encodeId=381691e09288, content=谵妄是老年患者预后不良的预警,不仅限于急性脑卒中。, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Sat Jan 16 08:36:43 CST 2021, time=2021-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=917066, encodeId=214291e066a9, content=<a href='/topic/show?id=e737104148e4' target=_blank style='color:#2F92EE;'>#卒中后谵妄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104148, encryptionId=e737104148e4, topicName=卒中后谵妄)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Sat Jan 16 07:44:54 CST 2021, time=2021-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=917064, encodeId=3a9b91e064d9, content=自然病程,自然转归?, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b7a31928393, createdName=学医无涯, createdTime=Sat Jan 16 07:17:33 CST 2021, time=2021-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026748, encodeId=25211026e4887, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Sat Jan 16 02:26:40 CST 2021, time=2021-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=917041, encodeId=b3c891e04121, content=学习啦, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Sat Jan 16 00:03:32 CST 2021, time=2021-01-16, status=1, ipAttribution=)]
    2021-01-16 学医无涯

    自然病程,自然转归?

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1671418, encodeId=d9a816e141814, content=<a href='/topic/show?id=9f4e360191a' target=_blank style='color:#2F92EE;'>#卒中后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36019, encryptionId=9f4e360191a, topicName=卒中后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ff7426824786, createdName=waiwai3039, createdTime=Thu May 13 02:26:40 CST 2021, time=2021-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=953136, encodeId=809e953136e0, content=了解到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=38665453234, createdName=ms4000001106117873, createdTime=Thu Apr 01 18:36:23 CST 2021, time=2021-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=917280, encodeId=a92391e280e2, content=长知识啦!, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f355090263, createdName=145d01efm82暂无昵称, createdTime=Sat Jan 16 23:12:32 CST 2021, time=2021-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=917195, encodeId=edc191e19565, content=谢谢分享,受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5c3c5448089, createdName=ms7000000496107358, createdTime=Sat Jan 16 17:56:05 CST 2021, time=2021-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=917098, encodeId=6e1a91e098d1, content=临床是很常见, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201118/644810206ca744f48355b4fc9381cc58/9cfe32903b6a495d8bdfc124267ba3d3.jpg, createdBy=ef782028905, createdName=种鱼的猫猫, createdTime=Sat Jan 16 08:54:47 CST 2021, time=2021-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=917092, encodeId=381691e09288, content=谵妄是老年患者预后不良的预警,不仅限于急性脑卒中。, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Sat Jan 16 08:36:43 CST 2021, time=2021-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=917066, encodeId=214291e066a9, content=<a href='/topic/show?id=e737104148e4' target=_blank style='color:#2F92EE;'>#卒中后谵妄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104148, encryptionId=e737104148e4, topicName=卒中后谵妄)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Sat Jan 16 07:44:54 CST 2021, time=2021-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=917064, encodeId=3a9b91e064d9, content=自然病程,自然转归?, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b7a31928393, createdName=学医无涯, createdTime=Sat Jan 16 07:17:33 CST 2021, time=2021-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026748, encodeId=25211026e4887, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Sat Jan 16 02:26:40 CST 2021, time=2021-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=917041, encodeId=b3c891e04121, content=学习啦, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Sat Jan 16 00:03:32 CST 2021, time=2021-01-16, status=1, ipAttribution=)]
    2021-01-16 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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    2021-01-16 tanxingdoctor

    学习啦

    0

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