Lancet Child Adolesc Health:小孩太胖也会动脉变硬!科学家分析未成年人数据发现,肥肉含量竟也与动脉僵硬度显著相关,减肥越早越好

2019-06-29 奇点糕 奇点网

相信大家都知道,肥胖可不是件小事情,和诸多疾病风险增加有关。但是,那些研究大多是成人甚至老年人的队列,让人都有些忽略了,小朋友也是会胖的。

相信大家都知道,肥胖可不是件小事情,和诸多疾病风险增加有关。但是,那些研究大多是成人甚至老年人的队列,让人都有些忽略了,小朋友也是会胖的。

伦敦大学John E Deanfield教授的最新研究成果就给大家敲了一记警钟,小朋友的肥胖也没有这么简单!

John E Deanfield教授和他的研究团队随访了3423名小朋友,在他们9岁-17岁检测肥胖状况,发现身体的总脂肪量和动脉僵硬度显示出显着的相关性。也就是说,那些看上去肉呼呼圆溜溜可可爱爱的小朋友,可能已经有点动脉僵硬了!研究发表在柳叶刀子刊Child&Adolescent Health上。

这可绝对不是个可爱的消息。少壮不减肥,动脉徒伤悲啊~~


通讯作者John E Deanfield教授

(图源:ucl.ac.uk)

肥胖这个问题,放到哪儿都是个大问题。关于肥胖相关的疾病风险、怎么吃能避免肥胖、治疗肥胖的108个靶点之类的研究,奇点糕每种都讲过很多遍。但是仔细一盘算,确实大多是关注成年人或者中老年人的相关研究,对于儿童和少年肥胖问题,似乎很少提及。

但是现在这个情况,教育都知道要从娃娃抓起了,减肥这个事情是不是也有必要从娃娃抓起呢?少年的肥胖又会对之后的健康产生多大的影响?动脉粥样硬化之类常见的“肥胖并发症”,会不会也会发生在这些花季的少男少女身上?这些就是John E Deanfield教授和他的研究团队想要解决的问题了。


(图源:pixabay.com)

ALSPAC是一项前瞻性的出生队列研究,旨在调查影响儿童正常发育和生长的因素,肥胖原因当然也在观察之列。这次的研究共纳入3424名参与者,其中45.5%为男性。小朋友们分别在9岁、11岁、13岁、15岁和17岁评估身体脂肪量,计算脂肪质量指数(FMI,计算方法是脂肪量除以身高的平方,和BMI类似),并在基线和结束时检测颈动脉和股动脉脉搏波速度,用以表征动脉僵硬度。

这些参与者中,65%在9岁和17岁时的FMI都很正常;当然,也有从头至尾都不重视体重管理、脂肪一直超标的,这部分人占了16%;还有10%的人起初身材不错,但是17岁时就已经自我放飞;剩下的9%堪称励志,9岁的时候还是个小胖墩,17岁就已经减肥成功了。

17岁时身体状况和动脉僵硬度之间的关系

研究人员将两个年龄段的数据分别进行了分析,发现身体的总脂肪量和动脉僵硬程度呈现正相关,在调整人口统计学、血液动力学、代谢参数等之后,这种关联依然存在,并且9岁时的关联强度比17岁时更高,这就不得不让人想到,9岁时的体重干预会不会对动脉僵硬产生更加长期的有益影响?翻译成白话就是,减肥这个事儿是不是越早越好?

在9%的减肥成功的参与者中,虽然他们初期脂肪量较高、代谢有些不健康,但是在FMI恢复正常之后,代谢也回归正常,动脉僵硬度和健康人没什么两样。这就说明,减肥趁早,不仅起效快,还没有遗留问题,值得小胖墩儿们提上日程。

在关注FMI的同时,也要注意代谢健康。因为研究人员发现,有些小朋友在检测的两个时期,FMI都在正常范围内,但是代谢却不是很健康,这部分人,也同样会出现动脉僵硬的症状。

还有一些小朋友,虽然还没有产生代谢异常,但是FMI较高,也表现出动脉僵硬度升高。说明即使没有其他风险因素,把多余的脂肪减一减也是可以获益的。这就在研究人员之前试验结果的基础上更加强调了,生命中任何时期的一点减肥,也可以有益于血管健康。

总而言之,虽然小朋友们长得快,胖了瘦了可能只需要一两个礼拜,但是长期的肥胖在任何时期都是需要提高警惕的事情!不然年纪轻轻的就动脉僵硬,对心血管可太不友好了。

原始出处:Frida Dangardt, Marietta Charakida, Georgios Georgiopoulos, et al. Association between fat mass through adolescence and arterial stiffness: a population-based study from The Avon Longitudinal Study of Parents and Children. The Lancet Child & Adolescent Health, July 2019

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    2019-10-21 shizhenshan
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    2019-07-14 howi
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GetPortalCommentsPageByObjectIdResponse(id=1628201, encodeId=cf8e1628201df, content=<a href='/topic/show?id=9bef81890f0' target=_blank style='color:#2F92EE;'>#肥肉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81890, encryptionId=9bef81890f0, topicName=肥肉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=132621174056, createdName=hb2015ye, createdTime=Sun Jun 30 20:47:00 CST 2019, time=2019-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368647, encodeId=fbf336864ed0, content=胖都不是好事啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43a21971117, createdName=njwbhuang, createdTime=Sun Jun 30 08:20:52 CST 2019, time=2019-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368596, encodeId=00d83685962b, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sat Jun 29 09:00:34 CST 2019, time=2019-06-29, status=1, ipAttribution=)]
  8. 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objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33216, encryptionId=96a0332168b, topicName=动脉僵硬度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eb8013942519, createdName=1696533704_45270458, createdTime=Sun Jun 30 20:47:00 CST 2019, time=2019-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1621806, encodeId=94331621806f0, content=<a href='/topic/show?id=5f1386329e' target=_blank style='color:#2F92EE;'>#Health#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8632, encryptionId=5f1386329e, topicName=Health)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8d2020283215, createdName=yyanpro@28cn.c, createdTime=Sun Jun 30 20:47:00 CST 2019, time=2019-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1628201, encodeId=cf8e1628201df, content=<a href='/topic/show?id=9bef81890f0' target=_blank style='color:#2F92EE;'>#肥肉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81890, encryptionId=9bef81890f0, topicName=肥肉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=132621174056, createdName=hb2015ye, createdTime=Sun Jun 30 20:47:00 CST 2019, time=2019-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368647, encodeId=fbf336864ed0, content=胖都不是好事啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43a21971117, createdName=njwbhuang, createdTime=Sun Jun 30 08:20:52 CST 2019, time=2019-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368596, encodeId=00d83685962b, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sat Jun 29 09:00:34 CST 2019, time=2019-06-29, status=1, ipAttribution=)]
    2019-06-30 hb2015ye
  9. [GetPortalCommentsPageByObjectIdResponse(id=1861327, encodeId=1157186132e59, content=<a href='/topic/show?id=401a23e102' target=_blank style='color:#2F92EE;'>#ALT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2371, encryptionId=401a23e102, topicName=ALT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ccbd84, createdName=shizhenshan, createdTime=Mon Oct 21 00:47:00 CST 2019, time=2019-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1830136, encodeId=ab5118301361b, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, 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objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33216, encryptionId=96a0332168b, topicName=动脉僵硬度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eb8013942519, createdName=1696533704_45270458, createdTime=Sun Jun 30 20:47:00 CST 2019, time=2019-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1621806, encodeId=94331621806f0, content=<a href='/topic/show?id=5f1386329e' target=_blank style='color:#2F92EE;'>#Health#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8632, encryptionId=5f1386329e, topicName=Health)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8d2020283215, createdName=yyanpro@28cn.c, createdTime=Sun Jun 30 20:47:00 CST 2019, time=2019-06-30, status=1, ipAttribution=), 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GetPortalCommentsPageByObjectIdResponse(id=368596, encodeId=00d83685962b, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sat Jun 29 09:00:34 CST 2019, time=2019-06-29, status=1, ipAttribution=)]
    2019-06-30 njwbhuang

    胖都不是好事啊

    0

  10. 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GetPortalCommentsPageByObjectIdResponse(id=1628201, encodeId=cf8e1628201df, content=<a href='/topic/show?id=9bef81890f0' target=_blank style='color:#2F92EE;'>#肥肉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81890, encryptionId=9bef81890f0, topicName=肥肉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=132621174056, createdName=hb2015ye, createdTime=Sun Jun 30 20:47:00 CST 2019, time=2019-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368647, encodeId=fbf336864ed0, content=胖都不是好事啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43a21971117, createdName=njwbhuang, createdTime=Sun Jun 30 08:20:52 CST 2019, time=2019-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368596, encodeId=00d83685962b, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sat Jun 29 09:00:34 CST 2019, time=2019-06-29, status=1, ipAttribution=)]
    2019-06-29 龙胆草

    学习谢谢分享

    0

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