Sci Rep:α-硫辛酸的抗过敏性鼻炎活性研究

2020-08-16 AlexYang MedSci原创

最近,有研究人员建立了一个卵清蛋白(OVA)诱导的过敏性鼻炎(AR)小鼠模型来调查了是否α-硫辛酸(LA)对上呼吸道炎症具有保护作用。

最近,有研究人员建立了一个卵清蛋白(OVA)诱导的过敏性鼻炎(AR)小鼠模型来调查了是否α-硫辛酸(LA)对上呼吸道炎症具有保护作用。

研究人员通过通过腹腔注射BALB/c小鼠致敏,并通过鼻腔使用OVA进行过敏原挑战。小鼠在OVA挑战前1小时口服各种剂量的LA(2、10、50 mg/kg)和地塞米松(Dex;2.5 mg/kg)。研究人员测量了过敏性鼻腔症状、OVA特异性免疫球蛋白水平、细胞因子和转录因子的水平,并对鼻腔和肺部组织病理学进行了评估。研究发现,LA治疗组的Treg细胞因子IL-10和Treg转录因子Foxp3水平明显上调。与之相反,Th17细胞因子IL-17和Th17转录因子STAT3、RORγ的水平下调。LA极大增强了核因子红细胞衍生2/血红素氧合酶1(Nrf2/HO-1)通路信号传导,并抑制了NF-κB/IκB的激活,明显抑制了促炎细胞因子TNF-α、IL-1β、IL-6、IL-8和趋化因子COX-2的水平。另外,LA能有效改善AR小鼠鼻腔和肺组织的组织学改变。

LA治疗减轻鼻粘膜肿胀和浸润炎症细胞和杯状细胞的积累

LA治疗减轻肺组织的炎症

最后,研究人员基于这些结果,认为LA凭借在控制Th17/Treg平衡和增强Nrf2/HO-1通路信号的作用,可以作为OVA诱导AR的潜在治疗药物。

原始出处:

Thi Van Nguyen, Chun Hua Piao, Yan Jing Fan et al. Anti-allergic rhinitis activity of α-lipoic acid via balancing Th17/Treg expression and enhancing Nrf2/HO-1 pathway signaling. Sci Rep. Jul 2020

 

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    2022-08-08 屋顶瞄爱赏月

    签到学习

    0

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    2022-05-01 病毒猎手

    #α-硫辛酸#是一种保健品,能对抗#过敏性鼻炎#,有点令人不敢相信

    0

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    2020-08-16 tounao

    有意思的研究

    0

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