Front Immunol:葡萄膜炎是强直性脊柱炎发展为急性心肌梗塞的危险因素

2022-02-19 医路坦克 MedSci原创

强直性脊柱炎(AS)是一种慢性炎症性疾病,葡萄膜炎患者发生急性心肌梗死的概率较高,而不考虑其并存情况。与不合并葡萄膜炎的患者相比,合并葡萄膜炎的患者发生急性心肌梗死的风险更高。

    强直性脊柱炎(AS)是一种慢性炎症性疾病。AS患者存在过多的心血管风险,并被归因于长期的全身炎症。葡萄膜炎是强直性脊柱炎最常见的关节外症状之一,也被认为是全身炎症的指标。本研究旨在利用国家健康保险研究数据库(NHIRD)调查葡萄膜炎是否是AS患者发生急性心肌梗死(AMI)的危险因素。

   数据是从NHIRD收集的,历时15年。变量分析采用皮尔逊卡方检验和费雪精确检验。通过计算危险比,分析急性心肌梗死发生的危险因素。采用Kaplan-Meier分析比较葡萄膜炎组和非葡萄膜炎组急性心肌梗死的累积发病率。

    共纳入5905例AS患者,其中葡萄膜炎患者1181例(20%),非葡萄膜炎患者4724例(80%)。卡普兰-迈耶方法和对数秩检验表明,葡萄膜炎组的急性心肌梗死患者的累积风险显著高于非葡萄膜炎组(p<0.001)。葡萄膜炎组急性心肌梗死的调整危险比(AHR)高于非葡萄膜炎组(AHR=1.653,p<0.001)。分层分析显示,葡萄膜炎患者发生急性心肌梗死的风险增加,不分性别(男性/女性AHR=1.688/1.608,p<0.001)。与无葡萄膜炎患者相比,各年龄段葡萄膜炎患者发生急性心肌梗死的风险均独立增加(20~39岁/40~59岁/≥60岁,aHR=1.550,1.579,3.240,p<0.001)。

    葡萄膜炎患者发生急性心肌梗死的概率较高,而不考虑其并存情况。与不合并葡萄膜炎的患者相比,合并葡萄膜炎的患者发生急性心肌梗死的风险更高。

    葡萄膜炎是AS患者发生急性心肌梗死的重要危险因素。医生应该意识到AS患者合并葡萄膜炎的潜在心血管风险,特别是与其他传统的AMI危险因素同时存在的风险。需要进一步的前瞻性研究来阐明AS患者葡萄膜炎和AMI之间的潜在机制。

文献来源:Lai YF,  Lin TY,  Chien WC,Uveitis as a Risk Factor for Developing Acute Myocardial Infarction in Ankylosing Spondylitis: A National Population-Based Longitudinal Cohort Study,Front Immunol 2021;12 

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    2022-05-25 屋顶瞄爱赏月

    签到学习

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    2022-07-30 zywlvao
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1222239, encodeId=a2801222239cf, content=签到学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211111/81c0b64745c644319545ec26d7ef0b34/9ddb2864d5df4dd9bf4305e380bffc96.jpg, createdBy=c7835705079, createdName=屋顶瞄爱赏月, createdTime=Wed May 25 08:53:07 CST 2022, time=2022-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1946927, encodeId=47b4194692ebc, content=<a href='/topic/show?id=9a3950183e9' target=_blank style='color:#2F92EE;'>#强直性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50183, encryptionId=9a3950183e9, topicName=强直性)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKeia4TJeMGvEH3wKKIBNjuHuIic1HDNOB10j4tCd3nbylxkxm6HSMfEaKkSu6OZOak4uZv7UVicsWEg/132, createdBy=bc9a2500116, createdName=zywlvao, createdTime=Sat Jul 30 00:52:20 CST 2022, time=2022-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1440435, encodeId=833f14404355b, content=<a href='/topic/show?id=6f0e845427f' target=_blank style='color:#2F92EE;'>#脊柱炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84542, encryptionId=6f0e845427f, topicName=脊柱炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=50834728424, createdName=1249898am16暂无昵称, createdTime=Mon Feb 21 07:52:20 CST 2022, time=2022-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508693, encodeId=f21b150869377, content=<a href='/topic/show?id=e64b52283a7' target=_blank style='color:#2F92EE;'>#急性心肌梗塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52283, encryptionId=e64b52283a7, topicName=急性心肌梗塞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bbe29994869, createdName=zhty5340, createdTime=Mon Feb 21 07:52:20 CST 2022, time=2022-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1195294, encodeId=b393119529449, content=理解一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=066c2128345, createdName=1351fc2f66m, createdTime=Sun Feb 20 10:45:37 CST 2022, time=2022-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1195276, encodeId=c1e511952e63f, content=<a href='/topic/show?id=97ca8828218' target=_blank style='color:#2F92EE;'>#葡萄膜炎#</a>是<a href='/topic/show?id=d38b501864f' target=_blank style='color:#2F92EE;'>#强直性脊柱炎#</a>发展为急性<a href='/topic/show?id=b086512e33c' target=_blank style='color:#2F92EE;'>#心肌梗死#</a>的危险因素,将这三者紧密联系在一起,事实上,许多<a href='/topic/show?id=cc30104459e6' target=_blank style='color:#2F92EE;'>#风湿类疾病#</a>都有<a href='/topic/show?id=974e51e2810' target=_blank style='color:#2F92EE;'>#心血管#</a>的并发症, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88282, encryptionId=97ca8828218, topicName=葡萄膜炎), TopicDto(id=50186, encryptionId=d38b501864f, topicName=强直性脊柱炎), TopicDto(id=51273, encryptionId=b086512e33c, topicName=心肌梗死), TopicDto(id=104459, encryptionId=cc30104459e6, topicName=风湿类疾病), TopicDto(id=51728, encryptionId=974e51e2810, topicName=心血管)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=医者仁者, createdTime=Sun Feb 20 09:07:42 CST 2022, time=2022-02-20, status=1, ipAttribution=)]
    2022-02-20 1351fc2f66m

    理解一下

    0

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    2022-02-20 医者仁者

    #葡萄膜炎##强直性脊柱炎#发展为急性#心肌梗死#的危险因素,将这三者紧密联系在一起,事实上,许多#风湿类疾病#都有#心血管#的并发症

    0

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