JACC:心梗会影响主动脉反流患者的二尖瓣生长和功能

2020-02-17 不详 MedSci原创

二尖瓣环扩大是预防由慢性主动脉反流(AR)所致左室扩张引起的二尖瓣反流,这种扩张在功能性二尖瓣返流患者中是缺乏的,而在缺血性心肌病患者中仍然很常见。本研究提出假设:心梗会损害AR患者瓣叶的生长,并引起二三尖瓣的纤维性改变。本研究对AR、AR+心梗和对照山羊模型进行90天的随访,并通过心脏磁共振、超声心动图和计算机断层扫描于基线水平和随访90天后测量山羊的左室容积、左室功能、二尖瓣反流和二尖瓣叶大小

二尖瓣环扩大是预防由慢性主动脉反流(AR)所致左室扩张引起的二尖瓣反流,这种扩张在功能性二尖瓣返流患者中是缺乏的,而在缺血性心肌病患者中仍然很常见。本研究提出假设:心梗会损害AR患者瓣叶的生长,并引起二三尖瓣的纤维性改变。

本研究对AR、AR+心梗和对照山羊模型进行90天的随访,并通过心脏磁共振、超声心动图和计算机断层扫描于基线水平和随访90天后测量山羊的左室容积、左室功能、二尖瓣反流和二尖瓣叶大小。结果显示,两个实验组的山羊均表现为相似的左室扩张和功能不全,随访90天后,二尖瓣环大小在AR+心梗组中明显更小(p = 0.03),二尖瓣反流分数在AR组中为4% ± 7%,在AR+心梗组中为19% ± 10%(P=0.02)。AR+心梗组山羊的瓣叶明显厚于AR组和对照组。另外,AR+心梗组山羊的二三尖瓣叶的细胞外基质重塑基因表达也明显增高。

研究结果显示,在主动脉瓣反流动物模型中,心梗的存在会损坏二三尖瓣叶的生长和功能。

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    2020-08-11 hbwxf
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    2020-02-19 wwzzly
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    2020-02-19 feifers

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